Abstract
Characterizing the potential for drug-drug interactions is critical to underwriting patient safety as new chemical entities proceed through the drug discovery and development pipeline. In vitro experiments to characterize the type and extent of interaction have been developed to inform chemical modifications early in discovery and to estimate the magnitude of potential interactions as drugs progress into the clinic. Regulatory guidance provides flow schemes based on a comprehensive understanding of drug disposition to enable decision-making as to whether particular clinical interaction studies need to be run and, if so, how they may be designed. Integration of information from in vitro, in vivo, and clinical sources provides the basis for drug labeling and the safe administration of drugs post-launch.
Keywords
- Drug-drug Interactions (DDIs)
- Pharmaceutical Research And Manufacturers Of America (PhRMA)
- Plasma Protein Displacement
- Uridine 5′-diphospho-glucuronosyltransferase (UGTs)
- Free Drug Hypothesis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Wahlstrom, J., Wienkers, L. (2018). In Vitro/In Vivo Correlation for Drug-Drug Interactions. In: Hock, F., Gralinski, M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-56637-5_14-1
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DOI: https://doi.org/10.1007/978-3-319-56637-5_14-1
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