Abstract
Ganoderma lucidum is a highly praised medicinal mushroom having high demand worldwide. Intense research activities are being carried out on the medicinal applications of this mushroom that include anticancer, antiallergic, antioxidant potential, etc. This wonder mushroom contains many bioactive compounds such as polysaccharides, triterpenes, polyphenols, proteins, amino acids, and organic germanium. Ancient Chinese use this mushroom in their medicinal preparations and declared good health and longevity. Health benefits of this mushroom are highly praised in ancient manuscripts. Many pharmaceutical and beauty products made from this mushroom are available in the markets and demands high price. Cultivation and production of this mushroom are limited to certain countries, which leads to an increase in its market value. This chapter describes the details of this special mushroom, including its taxonomy, morphology, ecological and economic status, cultivation, bioactive molecules, and its medicinal applications.
Abbreviations
- C:N:
-
Carbon nitrogen ratio
- EPS:
-
Extracellular polysaccharides
- G. lucidum :
-
Ganoderma lucidum
- GA:
-
Ganoderic acid
- GTS:
-
Ganoderma triterpenes
- HDP:
-
Host Defense Potentiators
- IPS:
-
Intracellular polysaccharides
- LSC:
-
Liquid state cultivation
- LSF:
-
Liquid state fermentation
- LZ:
-
Lingzhi
- PBP:
-
Protein-bound polysaccharide
- RIP:
-
Ribosome inactivating proteins
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
- SSC:
-
Solid state cultivation
- SSF:
-
Solid state fermentation
References
Wachtel-Galor S, Buswell JA, Tomlinson B, Benzie IFF (2004a) Lingzhi polyphorous fungus. In: Herbal and traditional medicine: molecular aspects of health. Marcel Dekker, New York, pp 179–228
Wasser SP (2005) Reishi or Lingzhi (G. lucidum). In: Coates P, Blackman MR, Cragg G, Levine M, Moss J, White J (eds) Encyclopaedia of dietary supplements. Marcel Dekker, New York, pp 603–622
Hou RH, Liao ST (2009) Research development of the artificial cultivation of G. lucidum in China. Guangdong Agric Sci 11:29–32. (In Chinese)
Hirose K, Niimura K, Ohara M, Oguchi Y, Matsunaga K, Kadochi J, Sugita N, Furushu T, Yoshikumi C (1988) Antiviral agent. J. P. Patent No.63316734
Boh B, Berovic M, Zhang J, Zhi-Bin L (2007) G. lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 13:265–301
Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME (1999) Mushrooms, tumours, and immunity. Proc Soc Exp Biol Med 221(4):281–293
Mau JL, Lin HC, Ma JT, Song SF (2001a) Non-volatile taste components of several specialty mushrooms. Food Chem 73:461–466
Joo SS, Ryu IW, Park JK, Yoo YM, Lee DH, Hwang KW, Choi HT, Lim CJ, Lee DI, Kim K (2008) Molecular cloning and expression of a laccase from G. lucidum, and its antioxidative properties. Mol Cell 25(1):112–118
Leung SWS, Yeung KY, Ricky YLS, Man YK (2002) Lingzhi (Ganoderma) research the past, present and future perspectives. In: Lin ZB (ed) Ganoderma: genetics, chemistry, pharmacology and therapeutics. Beijing medical University Press, Beijing, pp 1–9
Kim HW, Kim B (2002) Recent advances on the biologically active triterpenoids of G. lucidum. In: Zhi-Bin Lin (ed) Ganoderma: genetics, chemistry, pharmacology and therapeutics. Proceedings of international symposium on Ganoderma research, Shanghai, 21–23 Oct, Beijing, Medical University Press, pp 10–19
Chang ST, Buswell J (1999) G. lucidum (Curt.: Fr.) P. Karst. (Amphyllophoromycetidae) – a mushrooming medicinal mushroom. Int J Med Mush 1(2):139–146
Lin SC (2000) Medicinal fungi of China-production and products development. Chinese Agricultural Press, Beijing
Chang ST, Buswell JA (2008) Safety quality control and regulational aspects relating to mushroom nutriceuticals. In: Proceedings of 6th international conference on mushroom biology and mushroom products, GAMU Gmbh, Krefeld, pp 188–95
Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF (2011) Chapter 9: G. lucidum (Lingzhi or Reishi) a medicinal mushroom. In: Herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press, Boca Raton
Wang JL, Li YB, Liu RM (2010) A new ganoderic acid from G. lucidum mycelia. J Asian Nat Prod Res 12(8):727–730
Hanaoka R, Ueno Y, Tanaka S (2011) The water-soluble extract from cultured medium of G. lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid. Scand J Immunol 74(5):454–462
Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH (2006) In vitro and in vivo protective effects of proteoglycan isolated from mycelia of G. lucidum on carbon tetrachloride induced liver injury. World J Gastroenterol 12(9):1379–1385
Arora D (1986) Mushrooms demystified, 2nd edn. Ten Speed Press, Berkeley, pp 169–164. ISBN 0-89815. Available at http://www.mushworld.com/sub_en.html
Jungjing MA, Zhenjyi FU, Peiyan MA, Yanli SU, Qingjie Z (2007) Breaking and characteristics of G. lucidum spores by high speed centrifugal shearing pulveriser. J Wuhan Univ Technol Mat Sci Edit 22:617–621
Chen AW (1999) Cultivation of the medicinal mushroom G. lucidum (Curtis: Fr.) P. Karst (Reishi) in North America. Int J Med Mush 1(3):263–282
Jayasinghe C, Imtiaj A, Hur H, Lee GW, Lee TS, Lee UY (2008) Favourable culture conditions for mycelial growth of Korean wild strains in G. lucidum. Mycobiology 36(1):28–33
Magday JC Jr, Bungihan ME, Dulay RMR (2014) Optimization of mycelial growth and cultivation of fruiting body of Philippine wild strain of G. lucidum. Curr Res Environ Appl Mycol 4(2):162–172
Han JR, An CH, Yuan JM (2005) Solid-state fermentation of cornmeal with the basidiomycete G. lucidum for degrading starch and upgrading nutritional value. J Appl Microbiol 99(4):910–915
Erkel EI (2009) The effect of different substrate mediums on yield of G. lucidum (Fr.) Karst. J Food Agric Environ 7:841–844
Royse DJ (1996) Specialty mushrooms. In: Janick J (ed) Progress in new crops. ASHS Press, Arlington, pp 464–475
Chen AW (2003) A fresh look at an ancient mushroom G. lucidum (Reishi). MushWorld – Cultivation, 18 Mar 2003. Available at http://www.mushworld.com
Gonzalez-Matute R, Figlas D, Devalis R, Delmastro S, Curvetto N (2002) Sunflower seed hulls as a main nutrient source for cultivating G. lucidum. Micol Apl Int 14:19–24
Yang FC, Hsieh C, Chen HM (2003a) Use of stillage grain from a rice-spirit distillery in the solid state fermentation of G. lucidum. Process Biochem 39:21–26
Hsieh C, Yang F (2004) Reusing soy residue for the solid-state fermentation of G. lucidum. Bioresour Technol 91(1):105–109
Chen AW (2004) Growing Ganoderma mushrooms. Chapter 11. Mushrooms for the tropics. Part III. Mushroom worldwide. In: Mushroom grower’s handbook 1, Oyster Mushroom Cultivation. pp 224–234. Available at https://www.scribd.com/document/265831668/mushroom-growers-handbook-1-mushworld-com-chapter-11-pdf
Kim HK (2001) Comparison of characteristics of G. lucidum according to geographical origins: consideration of growth characteristics. World Mushroom. Available at http://www.mushworld.com/sub_en.html
Zhou XW, Siu K, Zhang YM (2012) Applied modern biotechnology for cultivation of Ganoderma and development of their products. Appl Microbiol Biotechnol 93:941–963
Xia ZN, Jiang JA, He CZ, Liu DY (2003) Preliminary researchers on high yield cultivation techniques of Ganoderma. Hunan Agric Sci Technol 6:56–58
Yan MH (2000) Cultivation of G. lucidum using oak leaf and waste tea. Edible Fungi 2:22–23
Han XH, Wang HZ, He B (2003) A preliminary study on nutritional conditions for the strain mycelium growth of several cultivars of Ganoderma. J Hainan Univ 16:88–92
Wu BF, Liu LL, Fang ZH, Liu XY (2008) Effect of nutrition factors on mycelium growth of 51427 in G. lucidum. Anhui Agric Sci Bull 14:57–58
Maldonado MC, Saad AMS (1998) Production of pectinesterase and polygalacturonase by Aspergillus niger in submerged and solid state systems. J Ind Microbiol Biotechnol 20:34–38
Mahapatra S, Banerjee D (2009) Extracellular tannase production by endophytic Hyalopus sp. J Gen Appl Microbiol 55:255–259
Sanodiya BS, Takur GS, Baghel RK, Prasad GB, Bisen PS (2009) G. lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol 10(8):717–742
Pandey A, Soccol CR, Mitchell D (2000) New developments in solid state fermentation: I- bioprocesses and products. Process Biochem 35:1153–1169
Habijanic J, Berovic M (2000) The relevance of solid-state substrate moisturing on G. lucidum biomass cultivation. Food Technol Biotechnol 38(3):225–228
Zhang W, Tang YJA (2008) Novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom G. lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnol Prog 24:1249–1261
Zhuang Y, Hong J (2006) Two-way pattern solid fermentation engineering in medicinal mushrooms and further development of Chinese medicine residue. Zhong Yao Cai 31:1918–1919
Zhuang Y, Pan Y, Xie XM, Zhang LY (2007) The origin, development and its advantage and potential of the bi-directional solid fermentation for medicinal fungi. Edible Fungi China 26:3–6
Chen HZ, Chen J (2004) A preliminary report on solid-state fermentation of G. lucidum with Radix astragali containing medium. Chin J Integr Med 2:216–218
Gu SR, Qin JZ, Chen H (2005) New solid fermentation of 14 Ganoderma strains and the study on polysaccharose content of the fermentation product. Lishizhen Med Mater Med Res 16:313–314
Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou S (2005) Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from G. lucidum in mice. Immunol Investig 34:171–198
You JJ (2009) The present status and future aspect of medicinal fungi in China. Edible Fungi Chin 28:3–5
Mckenna DJ, Jones K, Hughes K (2002) Reishi, botanical medicines. The desk reference for major herbal supplements, 2nd edn. The Haworth Herbal Press, New York/London/Oxford, pp 825–855
Paterson RRM (2006) Ganoderma – a therapeutic fungal biofactory. Phytochemistry 67(18):1985–2001
Zheng WF (2011) Drug discovery from fungal metabolites: a review of the papers in this monographical issue of mycosystema concerned with the natural resources, problems and strategies. Mycosystema 30:151–157
Bao XF, Dong Q, Fang JN (2000) Structure and conformation behaviour of a glucan from spores of G. lucidum (Fr.) Karst. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(6):557–561
Bao XF, Liu CP, Fang JN, Li XY (2001) Structural and immunological studies of a major polysaccharide from spores of G. lucidum (Fr.) Karst. Carbohydr Res 332:67–74
Bao XF, Wang XS, Dong Q (2002) Structural features of immunologically active polysaccharides from G. lucidum. Phytochemistry 59(2):175–181
Ho YW, Yeung JS, Chiu PK, Tang WM, Lin ZB, Man RY, Lau CS (2007) G. lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast. Mol Cell Biochem 301(1–2):173–179
Li Z, Liu J, Zhao Y (2005) Possible mechanism underlying the antiherpetic activity of a proteoglycan isolated from the mycelia of G. lucidum in vitro. J Biochem Mol Biol 38(1):34–40
Ji Z, Tang Q, Zhang J, Yang Y, Jia W, Pan Y (2007) Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from G. lucidum. J Ethnopharmacol 112(3):445–450
Wu Y, Wang D (2009) A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from G. lucidum fruiting bodies. J Proteome Res 8:436–442
Chien CM, Cheng JL, Chang WT (2004) Polysaccharides of G. lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorg Med Chem 12:5603–5609
Dong SF, Chen JM, Zhang W, Sun SH, Wang J, Gu JX, Boraschi D, Qu D (2007) Specific immune response to HBsAg is enhanced by β-glucan oligosaccharide containing α-(1→3)-linked bond and biased towards M2/Th2. Int Immunopharmacol 7:725–733
Fatmawati S, Kondo R (2011) Structure-activity relationships of ganoderma acids from G. lucidum as aldose reductase inhibitors. Bioorg Med Chem Lett 21(24):7295–7297
Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC (2007) The anti-invasive effect of lucidenic acids isolated from a new G. lucidum strain. Mol Nutr Food Res 51:1472–1477
Gao JI, Leung KS, Wang YT, Lai CM, Li SP, Hu LF, Lu GH, Jiang ZH, Yu ZL (2007) Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS. J Pharm Biomed Anal 44(3):807–811
Van Der Hem LG, Van Der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJ (1995) Lingzhi-8: studies of a new immunomodulating agent. Transplantation 60:438–443
Wang H, Ng TB (2006) Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom G. lucidum. Peptides 27(1):27–30
Kim SD, Nho HJ (2004) Isolation and characterization of alpha-glucosidase inhibitor from the fungus G. lucidum. J Microbiol 42(3):223–227
Liu JJ, Huang WH, Lv ML, Si JP, Guo BL, Li SJ (2011) Determination of Ergosterol in G. lucidum from different varieties and cultured tree species by HPLC. Zhong Yao Cai 34:187–190
Gao P, Hirano T, Chen Z, Yasuhara T, Nakata Y, Sugimoto A (2012) Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of G. lucidum (Reishi mushroom). Fitoterapia 83:490–499
Fukuzawa M, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y (2008) Possible involvement of long chain fatty acids in the spores of G. lucidum (Reishi Houshi) to its anti-tumor activity. Biol Pharm Bull 31:1933–1937
Matute RG, Serra A, Figlas D, Curvetto N (2011) Copper and zinc bioaccumulation and bioavailability of G. lucidum. J Med Food 14(10):1273–1279
Falandysz J (2008) Selenium in edible mushrooms. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26(3):256–299
Huie CW, Di X (2004) Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B 812:241–257
Chang YW, Lu T (2004) Molecular characterization of polysaccharides in hot water extracts of G. lucidum fruiting bodies. J Food Drug Anal 12:59–67
Gao Y, Zhou S, Chen G, Dai X, Ye J, Gao H (2002) A phase I/II study of a G. lucidum (Curt.: Fr.) P. Karst. (Lingzhi, Reishi mushroom) extract in patients with chronic hepatitis B. Int J Med Mush 4:321–327
Cheong J, Jung W, Park W (1999) Characterization of an alkali-extracted peptidoglycan from Korean G. lucidum. Arch Pharm Res 22:515–519
Fang QH, Zhong JJ (2002a) Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of G. lucidum. Process Biochem 37:769–774
Wang YY, Chen ST, Lin CC, Wong CH, Lin CH (2002) Studies on the immunomodulation and antitumor activities of G. lucidum (Reishi) polysaccharides: functional and proteomic analysis of fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem 10:1057–1062
Lin SQ, Wang SZ, Lin ZB, Lin YX (2002) Purification and identification of glycopeptides from G. lucidum fruit bodies cultivated with grass and wood log. In: Zhi-Bin Lin (ed) Ganoderma: genetics, chemistry, pharmacology and therapeutics. Proceedings of international symposium on Ganoderma research, Shanghai, 21–23 Oct, Beijing, Medical University Press, pp 109–114
Zhang QH, Lin ZB (1999) Effect of G. lucidum polysaccharides B on TNF-a and INF-g production and their mRNA expression. Beijing Yi Ke Da Xue Xue Bao 31:179–183
Ooi LSM, Ooi VEC, Fung MC (2002) Induction of gene expression of immunomodulatory cytokines in the mouse by a polysaccharide from G. lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mush 4:27–35
Kidd PH (2000) The use of mushroom glucans and proteoglycans in cancer treatment. Altern Med Rev 5:4–27
Kang YK, Yoon SI, Lee SY, Kim DD, Lee SJ, Park WH, Hudson SM (2010) Chitosan-coated poly (vinyl alcohol) nanofibers for wound dressings. J Biomed Mater Res Part B Appl Biomater 92(2):568–576
Wasser SP, Weis AL (1997) Reishi mushroom [G. lucidum (Curt.: Fr.) P. Karst.] In: Nevo E (ed) Medicinal mushrooms. Peledfus, Haifa, p 39
Hobbs CH (1995) Medicinal mushrooms: an exploration of tradition, healing and culture, 2nd edn. Botanica Press, Santa Cruz, p 252
Min BS, Gao JJ, Hattori M, Lee HK, Kim YH (2001) Anticomplement activity of terpenoids from the spores of G. lucidum. Planta Med 67(9):811–814
Luo J, Lin ZB (2002) Advances of pharmacological effects of triterpenes from G. lucidum. Acta Pharm Sin B 37:574–578
Frankel EN (1997) Nutritional benefits of flavonoids. In: Ohigashi H, Osawa T, Terao J, Watanabe S, Yoshikawa T (eds) Food factors for cancer prevention. Springer, Tokyo, pp 6l3–616
Decker EA (1997) Phenolics: prooxidants or antioxidants? Nutr Rev 55:396–407
Mau JL, Lin HC, Song SF (2002) Antioxidant properties of several specialty mushrooms. Food Res Int 35(6):519–526
Kumari K, Prakash V, Rana S, Sagar A (2016) In vitro antioxidant activity of methanolic extract of G. lucidum (Curt.) P. Karst. IJASR 1(5):51–54
Heleno SA, Barros L, Martins A, Ferreira ICFR (2012) Fruiting body spores and in vitro produced mycelium of G. lucidum from Northeast Portugal: a comparative study of the antioxidant potential of phenolic and polysaccharidic extracts. Food Res Int 46:135–140
Hajjaj H, Mace M, Roberts M, Niederberger P, Fay LB (2005) Effect of 26-oxygenosterols from G. lucidum and their activity as cholesterol synthesis inhibitors. Appl Environ Microbiol 71:3653–3658
Zhang CR, Yang SP, Yue JM (2008) Sterols and triterpenoids from the spores of G. lucidum. Nat Prod Res 22(13):1137–1142
Lv GP, Zhao J, Duan JA, Tang YP, Li SP (2012) Comparison of sterols and fatty acids in two species of Ganoderma. Chem Cent J 6(1):10
Xu XF, Yan HD, Chen J, Zhang XW (2011) Bioactive proteins from mushrooms. Biotechnol Adv 29:667–674
Kawagishi H, Yamawaki M, Ido M, Shimada A, Kinoshita T, Murata T, Usui T, Kimura A, Chiba S (1997) A lectin from mycelia of the fungus G. lucidum. J Phytochem 44:7–10
Li YG, Ji DF, Zhong S, Zhu JX, Chen S, Hu GY (2011a) Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signalling pathway in colorectal carcinoma. Int J Biol Macromol 48:511–517
Kino K, Yamashita A, Yamaoka K, Watanabe J, Tanaka S, Ko K, Shimizu K, Tsunoo H (1989) Isolated and characterization of a new immunomodulatory protein Lingzhi-8 (LZ-8), from G. lucidum. J Biol Chem 264:472–478
Li QZ, Wang XF, Zhou XW (2011b) Recent status and prospects of the fungal immunomodulatory protein family. Crit Rev Biotechnol 31:365–375
Tsai LL (2007) Immunomodulatory protein cloned from G. microsporum. US Patent US 7601808 B2
Huang J, Zhang LX, Hu SN, Yu LJ (2008) Optimizing expression of LZ-8 protein and primary assaying of its immunomodulatory activity. Zhejiang Univ (Agric & Life Sci) 34:7–12
Shimizu A, Yano T, Saito Y, Inada Y (1985) Isolation of an inhibitor of platelet aggregation from a fungus, G. lucidum. Biol Pharm Bull 33(7):3012–3015
Gao Y, Zhou SH, Huang M, Xu A (2003) Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (Aphyllophoromycetideae): a review. Int J Med Mush 5(3):235–246
Hardy S, Przybytkowski E, Joly E, Prentki M, Langelier Y (2003) Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. J Biol Chem 278:31861–31870
Ihayere CA, Oghenekaro AO, Osemwegie OO, Okhuoya JA (2010) Chemical nature of G. lucidum (Curtis) Karsten from woodlands of Edo state, Nigeria. C J Biol Sci 3:8–15
Mizuno T (1995) G. lucidum and G. tsugae: bioactive substances and medicinal effects. Food Rev Int 11(1):151–166
Stamets P (2000) Growing gourmet and medicinal mushrooms, 3rd edn. Ten Speed Press, Berkeley, p 339
Chen DH, Shiou WY, Wang KC, Hwang SY, Shie YT, Tsai CM, Shie JF, Chen KD (1999) Chemotaxonomy of triterpenoid pattern of HPLC of G. lucidum and G. tsugae. J Chin Inst Chem 46:47–51
Gao JJ, Nakamura N, Min BS, Hirakawa A, Zuo F, Hattori M (2004) Quantitative determination of bitter principles in specimens of G. lucidum using high-performance liquid chromatography and its application to the evaluation of Ganoderma products. Chem Pharm Bull 52(6):688–695
Liu GT (1999) Recent advances in research of pharmacology and clinical applications of Ganoderma P. Karst. species (Aphyllophoromycetideae) in China. Int J Med Mush 1(1):63–68
Chiu SW, Wang ZM, Leung TM, Moore D (2000) Nutritional value of Ganoderma extract and assessment of its genotoxicity and antigenotoxicity using comet assays of mouse lymphocytes. Food Chem Toxicol 38:173–178
Kolesnikova OP, Tuzova MN, Kozlov VA (1997) Screening of immunoactive properties of alkanecarbonic acid derivatives and germanium-organic compounds in vivo. Immunologiya 10:36–38
Li P, Yi L, Liu HJ (2011) Chapter 2: Collection and identification of raw herbal materials. In: Liu JH (ed) Traditional herbal medicine research methods: identification, analysis, bioassay, and pharmaceutical and clinical studies. John Wiley & Sons, Inc., Hoboken, New Jersey, pp 27–79
Krishnaswamy N (2010) Chemistry of natural products: the terpenes. Taylor & Francis Group, New York, pp 1–10
Kim DO, Lee CY (2003). Extraction and isolation of polyphenolics. In: Current protocols in food analytical chemistry, I:I1:I1.2 (Online)
Fan L, Li J, Deng K, Ai L (2012) Effects of drying methods on the antioxidant activities of polysaccharides extracted from G. lucidum. Carbohydr Polym 87(2):1849–1854
Liu GQ, Zhao Y, Wang XL, Zhu CY (2011) Response surface methodology for optimization of polysaccharides extraction by mild alkaline hydrolysis from fruiting body of medicinal mushroom, G. lucidum. J Med Plant Res 5(10):2064–2070
Chin SK, Law C, Cheng P (2011) Effect of drying on crude ganoderic acids and water soluble polysaccharides content in G. lucidum. Int J Pharm Pharm Sci 3:38–43
Chin SK, Law CL, Supramaniam CV, Cheng PG (2009) Thin-layer drying characteristics and quality evaluation of air-dried Ganoderma tsugae Murrill. Dry Technol 27(9):975–984
Huang SQ, Ning ZX (2010) Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity. Int J Biol Macromol 47(3):336–341
Liu W, Xu J, Jing P, Yao W, Gao X, Yu L (2010) Preparation of a hydroxypropyl G. lucidum polysaccharide and its physicochemical properties. Food Chem 122(4):965–971
Chen W, Wang WP, Zhang HS, Huang Q (2012) Optimization of ultrasonic-assisted extraction of water-soluble polysaccharides from Boletus edulis mycelia using response surface methodology. Carbohydr Polym 87(1):614–619
Wen L, Lin L, You L, Yang B, Jiang G, Zhao M (2011) Ultrasound-assisted extraction and structural identification of polysaccharides from Isodon lophanthoides var. gerardianus (Bentham) H. Hara. Carbohydr Polym 85(3):541–547
Zhao Q, Kennedy JF, Wang X, Yuan X, Zhao B, Peng Y et al (2011) Optimization of ultrasonic circulating extraction of polysaccharides from Asparagus officinalis using response surface methodology. Int J Biol Macromol 49(2):181–187
Chen X, Wang W, Li S, Xue J, Fan L, Sheng Z et al (2010) Optimization of ultrasound-assisted extraction of Lingzhi polysaccharides using response surface methodology and its inhibitory effect on cervical cancer cells. Carbohydr Polym 80(3):944–948
Hromadkova Z, Ebringerova A, Valachovič P (1999) Comparison of classical and ultrasound-assisted extraction of polysaccharides from Salvia officinalis L. Ultrason Sonochem 5(4):163–168
Huang SQ, Li JW, Wang Z, Pan HX, Chen JX, Ning ZX (2010) Optimization of alkaline extraction of polysaccharides from G. lucidum and their effect on immune function in mice. Molecules 15(5):3694–3708
Xu DJ, Xia Q, Wang JJ, Wang PP (2008) Molecular weight and monosaccharide composition of Astragalus polysaccharides. Molecules 13(10):2408–2415
Zhao L, Dong Y, Chen G, Hu Q (2010) Extraction, purification characterization and antitumor activity of polysaccharides from G. lucidum. Carbohydr Polym 80:783–789
Wakte P, Sachin B, Patil A, Mohato D, Band T, Shinde D (2011) Optimization of microwave, ultra-sonic and supercritical carbon dioxide assisted extraction techniques for curcumin from Curcuma longa. Sep Purif Technol 79(1):50–55
Claver IP, Zhang H, Li Qin Z, Huiming Z (2010) Optimization of ultrasonic extraction of polysaccharides from Chinese malted sorghum using response surface methodology. Pak J Nutr 9(4):336–342
Kozarski M, Klaus A, Nikšić M, Vrvić MM, Todorović N, Jakovljević D, Van Griensven LJ (2012) Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms G. applanatum, G. lucidum, Lentinus edodes and Trametes versicolor. J Food Compos Anal 26(1):144–153
Cheung YC, Siu KC, Liu YS, Wu JY (2012) Molecular properties and antioxidant activities of polysaccharide–protein complexes from selected mushrooms by ultrasound-assisted extraction. Process Biochem 47(5):892–895
Azmi AF, Mustafa S, Hashim DM, Manap YA (2012) Prebiotic activity of polysaccharides extracted from Gigantochloa levis (Buluh beting) shoots. Molecules 17(2):1635–1651
Li YQ, Fang L, Zhang KC (2007) Structure and bioactivities of a galactose rich extracellular polysaccharide from submergedly cultured G. lucidum. Carbohydr Polym 68(2):323–328
Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F (1956) Colorimetric method for determination of sugars and related substances. Anal Chem 28:350–356
Miyazaki T, Nishijima M (1982) Structural examination of an alkali-extracted, water-soluble hetero glycan of the fungus G. lucidum. Carbohydr Res 109(1):290–294
Sone Y, Okuda R, Wada N, Kishida E, Misaki A (1985) Structure and antitumor activities of the polysaccharide isolated from fruiting body and the growing culture of mycelium of G. lucidum. Agric Biol Chem 49:2641–2653
Kim HW, Kim BK (1999) Biomedical triterpenoids of G. lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mush 1(2):121–138
Min BS, Nakamura N, Miyashiro H et al (1998) Triterpenes from the spores of G lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull 46(10):1607–1612
Fang QH, Zhong JJ (2002b) Submerged fermentation of higher fungus G. lucidum for production of valuable bioactive metabolites – ganoderic acid and polysaccharide. Biochem Eng J 10:61–65
Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, Chang JY, Sun HH (2002) New lanostanoids from the mushroom G. lucidum. J Nat Prod 65:72–75
Tang YJ, Zhong JJ (2002) Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, G. lucidum, grown on lactose in a bioreactor. Biotechnol Lett 24:1023–1026
Kikuchi T, Kanomi S, Kadota S, Murai Y, Tsubono K, Ogita Z (1986) Constituents of the fungus G. lucidum (Fr.) Karst. I. Structures of ganoderic acids C2, E, I, and K, lucidenic acid F and related compounds. Chem Pharm Bull 34:3695–3712
Hirotani MA, Furaya T, Shiro M (1985) A ganoderic acid derivative, a highly oxygenated lanostane-type triterpenoid from G. lucidum. Phytochemistry 24(9):2055–2061
Sliva D (2004) Cellular and physiological effects of G. lucidum (Reishi). Mini-Rev Med Chem 4:873–879
Yuen JW, Gohel MD (2005) Anticancer effects of G. lucidum: a review of scientific evidence. Nutr Cancer 53:11–17
Tomasi S, Lohezic-Le DF, Sauleau P, Bezivin C, Boustie J (2004) Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. Pharmazie 59:290–293
Chen WC, Hau DM, Wang CC, Lin IH, Lee SS (1995) Effects of G. lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice. Am J Chin Med 23:289–298
Lu ZW (1995) Psycho-neuroimmunological effects of morphine and the immunoprotection of Ganoderma polysaccharides peptide in morphine dependent mice. Chin J Phys 26:45–49
Benzie IFF, Wachtel-Galor S (2009) Biomarkers of long-term vegetarian diets. Adv Clin Chem 47:169–220
Yuen JW, Gohel MD (2008) The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack. J Ethnopharmacol 118:324–330
Saltarelli R, Ceccaroli P, Lotti M, Zambonelli A, Buffalini M, Casadei L, Vallorani L, Stocchi V (2009) Biochemical characterisation and antioxidant activity of mycelium of G. lucidum from Central Italy. Food Chem 116:143–151
Wachtel-Galor S, Szeto YT, Tomlinson B, Benzie FIF (2004b) G. lucidum (Lingzhi): acute and short-term biomarker response to supplementation. Int J Food Sci Nutr 1:75–83
Ooi VEC, Liu F (2000) Immunomodulation and anti-cancer activity of polysaccharide–protein complexes. Curr Med Chem 7:715–729
Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, Baek SJ, Surh YJ (2001) Inhibition of lipid peroxidation and oxidative DNA damage by G. lucidum. Phytother Res 15:245–249
Shi YL, James AE, Benzie IF, Buswell JA (2002) Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA. Teratog Carcinog Mutagen 22:103–111
Sheena M, Ajith A, Janardhanan K (2003) Prevention of nephrotoxicity induced by the anticancer drug cisplatin, using G. lucidum, a medicinal mushroom occurring in South India. Curr Sci 85:478–482
Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA (2008) Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes. Cancer Sci 99:1461–1470
Jia J, Zhang XI, Hu YS, Wu Y, Wang QZ, Li NN, Guo QC, Dong XC (2009) Evaluation of in vivo antioxidant activities of G. lucidum polysaccharides in STZ-diabetic rats. Food Chem 115:32–36
Calder PC (2003) Immunonutrition: may have beneficial effects in surgical patients. BMJ 327(7407):117–118
Powell M (2006) G. lucidum (Reishi) in the management of histamine-mediated allergic responses. Townsend Letter pp 78–81
Yoon SY, Eo SK, Kim YS, Lee CK, Han SS (1994) Antimicrobial activity of G. lucidum extract alone and in combination with some antibiotics. Arch Pharm Res 17:438–442
Mohammed A, Adelaiye AB, Abubakar MS, Abdurahman EM (2007) Effects of aqueous extract of G. lucidum on blood glucose levels of normoglycemic and alloxan induced diabetic wistar rats. J Med Plant Res 1:34–37
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Sudheer, S., Alzorqi, I., Manickam, S., Ali, A. (2018). Bioactive Compounds of the Wonder Medicinal Mushroom “Ganoderma lucidum” . In: Mérillon, JM., Ramawat, K. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-54528-8_45-1
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