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Radiation Oncology pp 1–17Cite as

Signal Transduction in Radiation Oncology

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Abstract

Processes in cells in the human body and other organisms are controlled by specific and tightly regulated events. These events are called signal transduction. Signal transduction in normal, healthy cells differs profoundly from those occurring in cancer cells. In the context of radiation oncology and medical oncology, a thorough understanding of the underlying biology and signal transduction processes of tumors is needed for improvement of therapy and diagnosis on a personalized level. In this chapter, the principles of signal transduction are described, and examples are provided to demonstrate how different tumor and normal cells are regulated and how these differences might be exploitable for molecular-based therapeutic interventions in combination with radiotherapy.

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Authors and Affiliations

  1. Faculty of Medicine Carl Gustav Carus, OncoRay – National Center for Radiation Research in Oncology, Technische Universität Dresden, Dresden, Germany

    Nils Cordes & Irina Korovina

  2. Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Dresden, Germany

    Nils Cordes

  3. Helmholtz-Zentrum Dresden – Rossendorf, Instutite of Radiooncology – OncoRay, Dresden, Germany

    Nils Cordes, Josephine Görte & Sarah Förster

Authors
  1. Nils Cordes
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  2. Josephine Görte
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  3. Irina Korovina
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  4. Sarah Förster
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Corresponding author

Correspondence to Nils Cordes .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University Hospital Mannheim, Mannheim, Germany

    Frederik Wenz

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Cordes, N., Görte, J., Korovina, I., Förster, S. (2019). Signal Transduction in Radiation Oncology. In: Wenz, F. (eds) Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-52619-5_112-1

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  • DOI: https://doi.org/10.1007/978-3-319-52619-5_112-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52619-5

  • Online ISBN: 978-3-319-52619-5

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