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Breast Cancer pp 399–414Cite as

Breast Cancer in Lymphoma Survivors

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Abstract

Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world [1]. It is more common in developed countries, with an estimated 70,800 new cases in the United States (US) in 2014. Accounting for 4.3% of all cancers in the US, NHL ranks as the seventh most common cancer among males and the sixth most common cancer among females. NHL consists of more than 40 major subtypes with distinct genetic, morphologic, and clinical features. The incidence of NHL subtypes also varies by age, sex, ethnicity, and geographic region [2, 3]. Hodgkin lymphoma (HL) affects approximately 9050 new patients in the US each year [4], representing approximately 11.2% of all lymphomas. The disease has a bimodal distribution with an increased incidence in young adults as well as in patients 55 years and older [5].

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References

  1. Ferlay J, Soerjomataram I, Ervik M, et al (2012) GLOBOCAN 2012 v1.0. Cancer incidence and mortality worldwide

    Google Scholar 

  2. Surveillance, Epidemiology, and End Results(SEER) Program. National Cancer Institute, DCCPS, Cancer Statistics Branch (2011) www.seer.cancer.gov

  3. Surveillance, Epidemiology and End Results(SEER) Program Populations (1969-2009). National Cancer Institute, DCCPS, Cancer Statistics Branch 2011. www.seer.cancer.gov/popdata

  4. Siegel R, Miller KD, Jemal A (2015) Cancer statistics, 2015. CA Cancer J Clin 65:5–29

    Article  PubMed  Google Scholar 

  5. Glaser SL, Jarrett RF (1996) The epidemiology of Hodgkin’s disease. Baillieres Clin Haematol 9:401–416

    Article  CAS  PubMed  Google Scholar 

  6. Ward E, De Santis C, Robbins A et al (2014) Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 64:83–103

    Article  PubMed  Google Scholar 

  7. Miller KD, Siegel RL, Lin CC et al (2016) Cancer treatment and survivorship statistics 2016. CA Cancer J Clin 66:271–289

    Article  PubMed  Google Scholar 

  8. Surveillance, Epidemiology and End Results (SEER) Program. SEER*Stat Database: North American Association of Central Cancer Registries (NAACCR) Incidence-CiNA Analytic File, 1995–2012, for NHIAv2 Origin, Custom File With County, ACS Facts & Figures Projection Project, NAACCR (2015) Bethesda, MD: National Cancer Institute, Division of Cancer Control and Population Sciences, Surveillance Research Program, Cancer Statistics Branch

    Google Scholar 

  9. Tsai HK, Mauch PM (2007) Nodular lymphocyte predominant Hodgkin lymphoma. Semin Radiat Oncol 17:184–189

    Article  PubMed  Google Scholar 

  10. American College of Surgeons, Commission on Cancer (2015) National Cancer Database, 2013 data Submission. American College of Surgeons, Chicago, IL

    Google Scholar 

  11. Miller TP, Dahlberg S, Cassady JR et al (1998) Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin’s lymphoma. N Engl J Med 339:21–26

    Article  CAS  PubMed  Google Scholar 

  12. Coiffier B (2005) State-of-the-art therapeutics: diffuse large B-cell lymphoma. J Clin Oncol 23:6387–6393

    Article  CAS  PubMed  Google Scholar 

  13. Shankland KR, Armitage JO, Hancock BW (2012) Non-Hodgkin lymphoma. Lancet 380:848–857

    Article  PubMed  Google Scholar 

  14. Dores GM, Curtis RE, van Leeuwen FE et al (2014) Pancreatic cancer risk after treatment of Hodgkin lymphoma. Ann Oncol 25:2073–2079

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Morton LM, Gilbert ES, Stovall M et al (2014) Risk of esophageal cancer following radiotherapy for Hodgkin lymphoma. Haematologica 99:e193–e196

    Article  PubMed  PubMed Central  Google Scholar 

  16. van Eggermond AM, Schaapveld M, Lugtenburg PJ et al (2014) Risk of multiple primary malignancies following treatment of Hodgkin lymphoma. Blood 124:319–327

    Article  PubMed  Google Scholar 

  17. Morton LM, Dores GM, Curtis RE et al (2013) Stomach cancer risk after treatment for Hodgkin lymphoma. J Clin Oncol 31:3369–3377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Cooke R, Jones ME, Cunningham D et al (2013) Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors. Br J Cancer 108:2399–2406

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Swerdlow AJ, Cooke R, Bates A et al (2012) Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin’s lymphoma in England and Wales: a National Cohort Study. J Clin Oncol 30:2745–2752

    Article  PubMed  Google Scholar 

  20. Swerdlow AJ, Higgins CD, Smith P et al (2011) Second cancer risk after chemotherapy for Hodgkin’s lymphoma: a collaborative British cohort study. J Clin Oncol 29:4096–4104

    Article  CAS  PubMed  Google Scholar 

  21. De Bruin ML, Burgers JA, Baas P et al (2009) Malignant mesothelioma after radiation treatment for Hodgkin lymphoma. Blood 113:3679–3681

    Article  PubMed  Google Scholar 

  22. De Bruin ML, Sparidans J, van’t Veer MB et al (2009) Breast cancer risk in female survivors of Hodgkin’s lymphoma: lower risk after smaller radiation volumes. J Clin Oncol 27:4239–4246

    Article  PubMed  Google Scholar 

  23. van den Belt-Dusebout AW, Aleman BM, Besseling G et al (2009) Roles of radiation dose and chemotherapy in the etiology of stomach cancer as a second malignancy. Int J Radiat Oncol Biol Phys 75:1420–1429

    Article  PubMed  Google Scholar 

  24. Hodgson DC, Gilbert ES, Dores GM et al (2007) Long-term solid cancer risk among 5-year survivors of Hodgkin’s lymphoma. J Clin Oncol 25:1489–1497

    Article  PubMed  Google Scholar 

  25. Aleman BM, van den Belt-Dusebout AW, De Bruin ML et al (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109:1878–1886

    Article  CAS  PubMed  Google Scholar 

  26. Bhatia S, Yasui Y, Robison LL et al (2003) High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin’s disease: report from the Late Effects Study Group. J Clin Oncol 21:4386–4394

    Article  PubMed  Google Scholar 

  27. Travis LB, Hill DA, Dores GM et al (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 290:465–475

    Article  PubMed  Google Scholar 

  28. Dores GM, Metayer C, Curtis RE et al (2002) Second malignant neoplasms among long term survivors of Hodgkin’s disease: a population-based evaluation over 25 years. J Clin Oncol 20:3484–3494

    Article  PubMed  Google Scholar 

  29. Ng AK, Bernardo MV, Weller E et al (2002) Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 100:1989–1996

    Article  CAS  PubMed  Google Scholar 

  30. Travis LB, Gospodarowicz M, Curtis RE et al (2002) Lung cancer following chemotherapy and radiotherapy for Hodgkin’s disease. J Natl Cancer Inst 94:182–192

    Article  PubMed  Google Scholar 

  31. Swerdlow AJ, Schoemaker MJ, Allerton R et al (2001) Lung cancer after Hodgkin’s disease: a nested case-control study of the relation to treatment. J Clin Oncol 19:1610–1618

    Article  CAS  PubMed  Google Scholar 

  32. van Leeuwen FE, Klokman WJ, Veer MB et al (2000) Long-term risk of second malignancy in survivors of Hodgkin’s disease treated during adolescence or young adulthood. J Clin Oncol 18:487–497

    Article  PubMed  Google Scholar 

  33. Swerdlow AJ, Barber JA, Hudson GV et al (2000) Risk of second malignancy after Hodgkin’s disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 18:498–509

    Article  CAS  PubMed  Google Scholar 

  34. van Leeuwen FE, Klokman WJ, Stovall M et al (1995) Roles of radiotherapy and smoking in lung cancer following Hodgkin’s disease. J Natl Cancer Inst 87:1530–1537

    Article  PubMed  Google Scholar 

  35. van Leeuwen FE, Klokman WJ, Hagenbeek A et al (1994) Second cancer risk following Hodgkin’s disease: a 20-year follow-up study. J Clin Oncol 12:312–325

    Article  PubMed  Google Scholar 

  36. Ansell SM (2016) Hodgkin lymphoma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol 91:435–442

    Google Scholar 

  37. Specht L, Yahalom J, Illidge T et al (2014) Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the International Lymphoma Radiation Oncology Group (ILROG). Int J Radiat Oncol Biol Phys 89:854–862

    Article  PubMed  Google Scholar 

  38. Diehl V, Thomas RK, Re D (2004) Hodgkin’s lymphoma—diagnosis and treatment. Lancet Oncol 5:19–26

    Article  CAS  PubMed  Google Scholar 

  39. Schaapveld M, Aleman B, van Eggermond AM (2015) Second cancer risk up to 40 years after treatment for Hodgkin’s lymphoma. N Engl J Med 373:2499–2511

    Article  CAS  PubMed  Google Scholar 

  40. Hodgson DC, Gilbert ES, Dores GM et al (2007) Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma. Cancer 110:2576–2586

    Article  PubMed  Google Scholar 

  41. Dabaja BS, Rebueno NC, Mazloom A et al (2011) Radiation for Hodgkin’s lymphoma in young female patients: a new technique to avoid the breasts and decrease the dose to the heart. Int J Radiat Oncol Biol Phys 79:503–507

    Article  PubMed  Google Scholar 

  42. Engert A, Pluetschow A, Eich HT, Diehl V (2005) Combined modality treatment of two or four cycles of ABVD followed by involved field radiotherapy in the treatment of patients with early stage Hodgkin’s lymphoma: update interim analysis of the Randomised HD10 Study of the German Hodgkin Study Group (GHSG). Blood 106:2673

    Google Scholar 

  43. Eghbali E, Brice P, Cremmers GY et al (2005) Comparison of three radiation dose levels after EBVP regimen in favorable supradiaphragmatic clinical stages (CS) I-II Hodgkin’s lymphoma (HL): preliminary results of the EORTC-GELA H9-F Trial. Blood 106:814

    Google Scholar 

  44. Maraldo MV, Dabaja BS, Filippi AR et al (2015) Radiation therapy planning for early-stage Hodgkin lymphoma: experience of the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys 92:144–152

    Article  PubMed  Google Scholar 

  45. Girinsky T, Specht L, Ghalibafian M et al (2008) The conundrum of Hodgkin lymphoma nodes: to be or not to be included in the involved node radiation fields. The EORTC-GELA lymphoma group guidelines. Radiother Oncol 88:202–210

    Article  PubMed  Google Scholar 

  46. Girinsky T, van der Maazen R, Specht L et al (2006) Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: concepts and guidelines. Radiother Oncol 79:270–277

    Article  PubMed  Google Scholar 

  47. Chera BS, Rodriguez C, Morris CG et al (2009) Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin’s lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy. Int J Radiat Oncol Biol Phys 75:1173–1180

    Article  PubMed  Google Scholar 

  48. Bhatia S, Robison LL, Oberlin O et al (1996) Breast cancer and other second neoplasms after childhood Hodgkin’s disease. N Engl J Med 334:745–751

    Article  CAS  PubMed  Google Scholar 

  49. Travis LB, Hill D, Dores GM et al (2005) Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 97:1428–1437

    Article  PubMed  Google Scholar 

  50. Children’s Oncology Group (2006). www.survivorshipguidelines.org. Accessed 1 March 2015

  51. Howell SJ, Searle C, Goode V et al (2009) The UK national breast cancer screening programme for survivors of Hodgkin lymphoma detects breast cancer at an early stage. Br J Cancer 101:582–588

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Saslow D, Boetes C, Burke W et al (2007) American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin 57:75–89

    Article  PubMed  Google Scholar 

  53. Oeffinger KC, Ford JS, Moskowitz CS et al (2009) Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA 301:404–414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Wallace WH, Thompson L, Anderson RA, Guideline DG (2013) Long term follow-up of survivors of childhood cancer: summary of updated SIGN guidance. BMJ 346:f1190

    Article  CAS  PubMed  Google Scholar 

  55. Hodgson DC, Grunfeld E, Gunraj N et al (2010) A population-based study of follow-up care for Hodgkin lymphoma survivors: opportunities to improve surveillance for relapse and late effects. Cancer 116:3417–3425

    Article  PubMed  Google Scholar 

  56. Nathan PC, Ness KK, Mahoney MC et al (2010) Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study. Ann Intern Med 153:442–451

    Article  PubMed  PubMed Central  Google Scholar 

  57. Hodgson DC, Cotton C, Crystal P et al (2016) Impact of early breast cancer screening on mortality among young survivors of childhood Hodgkin’s lymphoma. J Natl Cancer Inst 108(7):pii: djw010

    Article  Google Scholar 

  58. Cutuli B, Borel C, Dhermain F et al (2001) Breast cancer occurred after treatment for Hodgkin’s disease: analysis of 133 cases. Radiother Oncol 59:247–255

    Article  CAS  PubMed  Google Scholar 

  59. Basu SK, Schwartz C, Fisher SG et al (2008) Unilateral and bilateral breast cancer in women surviving pediatric Hodgkin’s disease. Int J Radiat Oncol Biol Phys 72:34–40

    Article  PubMed  PubMed Central  Google Scholar 

  60. Cutuli B, de La Rochefordiere A, Dhermain F et al (1997) Bilateral breast cancer after Hodgkin disease. Clinical and pathological characteristics and therapeutic possibilities: an analysis of 13 cases. Cancer Radiother 1:300–306

    Article  CAS  PubMed  Google Scholar 

  61. Alm El-Din MA, Hughes KS, Finkelstein DM et al (2009) Breast cancer after treatment of Hodgkin’s lymphoma: risk factors that really matter. Int J Radiat Oncol Biol Phys 73:69–74

    Article  PubMed  Google Scholar 

  62. Wolden SL, Hancock SL, Carlson RW et al (2000) Management of breast cancer after Hodgkin’s disease. J Clin Oncol 18:765–772

    Article  CAS  PubMed  Google Scholar 

  63. Alm El-Din MA, Hughes KS, Raad RA et al (2009) Clinical outcome of breast cancer occurring after treatment for Hodgkin’s lymphoma: case-control analysis. Radiat Oncol 4:19

    Article  PubMed  Google Scholar 

  64. Haberer S, Belin S, Le Scodan R et al (2012) Locoregional treatment for breast carcinoma after Hodgkin’s lymphoma: the breast conservation option. Int J Radiat Oncol Biol Phys 82:145–152

    Article  Google Scholar 

  65. Broeks A, Braaf LM, Wessels LF et al (2010) Radiation-associated breast tumors display a distinct gene expression profile. Int J Radiat Oncol Biol Phys 76:540–547

    Article  PubMed  Google Scholar 

  66. Broeks A, Braaf LM, Huseinovic A et al (2007) Identification of women with an increased risk of developing radiation induced breast cancer: a case only study. Breast Cancer Res 9:R26

    Article  PubMed  PubMed Central  Google Scholar 

  67. Dores GM, Anderson WF, Beane Freeman LE, Fraumeni JF Jr et al (2010) Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin’s lymphoma treated with radiotherapy. Br J Cancer 103:1081–1084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. White JR, Halberg FE, Rabinovitch R et al (2008) American College of Radiology appropriateness criteria on conservative surgery and radiation: stages I and II breast carcinoma. J Am Coll Radiol 5:701–713

    Article  PubMed  Google Scholar 

  69. Wahner-Roedler DL, Nelson DF, Croghan IT et al (2003) Risk of breast cancer and breast cancer characteristics in women treated with supradiaphragmatic radiation for Hodgkin lymphoma: Mayo Clinic experience. Mayo Clin Proc 78:708–715

    Article  PubMed  Google Scholar 

  70. Morrow M, Strom EA, Bassett LW et al (2002) Standard for breast conservation therapy in the management of invasive breast carcinoma. CA Cancer J Clin 52:277–300

    Article  PubMed  Google Scholar 

  71. Yahalom J, Petrek JA, Biddinger PW (1992) Breast cancer in patients irradiated for Hodgkin’s disease: a clinical and pathologic analysis of 45 events in 37 patients. J Clin Oncol 10:1674–1681

    Article  CAS  PubMed  Google Scholar 

  72. Aref I, Cross P (2000) Conservative surgery and radiation therapy for early stage breast cancer after previous mantle radiation for Hodgkin’s disease. Br J Radiol 872:905–906

    Article  Google Scholar 

  73. Deutsch M, Gerszten K, Bloomer WD et al (2001) Lumpectomy and breast irradiation for breast cancer arising after previous radiotherapy for Hodgkin’s disease or lymphoma. Am J Clin Oncol 24:33–34

    Article  CAS  PubMed  Google Scholar 

  74. Nguyen SK, Dagnault A (2010) Breast-conserving therapy after previous irradiation for lymphoma. Breast Cancer Res Treat 96:89–93

    Google Scholar 

  75. Musio D, Dionisi F, Parisi G et al (2009) Therapeutic options for breast cancer treatment in patients previously irradiated for Hodgkin’s disease: radical mastectomy or conservative surgery followed by reirradiation? Clin Ter 160:311–314

    CAS  PubMed  Google Scholar 

  76. Sanna G, Lorizzo K, Rotmensz N et al (2007) Breast cancer in Hodgkin's disease and non-Hodgkin’s lymphoma survivors. Ann Oncol 18:288–292

    Article  CAS  PubMed  Google Scholar 

  77. Milano MT, Li H, Gail MH et al (2010) Long-term survival among patients with Hodgkin’s lymphoma who developed breast cancer: a population-based study. J Clin Oncol 28:5088–5096

    Article  PubMed  PubMed Central  Google Scholar 

  78. Cutuli B, Kanoun S, Tunon De Lara C et al (2012) Breast cancer occurred after Hodgkin’s disease: clinico-pathological features, treatments and outcome: analysis of 214 cases. Crit Rev Oncol Hematol (81):29–37

    Google Scholar 

  79. Aref I, Cross P (2000) Conservative surgery and radiation therapy for early stage breast cancer after previous mantle radiation for Hodgkin’s disease. Br J Radiol 73:905–906

    Article  CAS  PubMed  Google Scholar 

  80. Alm En-Din MA, Hughes KS, Raad RA et al (2009) Clinical outcome of breast cancer occurring after treatment for Hodgkin’s lymphoma: case-control analysis. Radiat Oncol 4:19

    Article  Google Scholar 

  81. Alm El-Din MA, El-Badawy SA, Taghian AG (2008) Breast cancer after treatment of hodgkin’s lymphoma: general review. Int J Radiat Oncol Biol Phys 72:1291–1297

    Article  PubMed  Google Scholar 

  82. Nguyen SK, Dagnault A (2010) Breast-conserving therapy after previous irradiation for lymphoma. Breast Cancer Res Treat 124:845–849

    Article  PubMed  Google Scholar 

  83. National comprehensive cancer network clinical practice guidelines in oncology: breast cancer. http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed 14 Nov 2014.

  84. Perera F, Engel J, Holliday R et al (1997) Local resection and brachytherapy confined to the lumpectomy site for early breast cancer: a pilot study. J Surg Oncol 65:263–267

    Article  CAS  PubMed  Google Scholar 

  85. Vicini F, Kini VR, Chen P et al (1999) Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy. J Surg Oncol 70:33–40

    Article  CAS  PubMed  Google Scholar 

  86. Baglan KL, Martinez AA, Frazier R et al (2001) The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 50:1003–1011

    Article  CAS  PubMed  Google Scholar 

  87. Krishnan L, Jewell WR, Tawfik OW et al (2001) Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer. Breast J 7:91–96

    Article  CAS  PubMed  Google Scholar 

  88. Njeh C, Saunders M, Langton C (2010) Accelerated Partial Breast Irradiation (APBI): a review of available techniques. Radiat Oncol 5:90

    Article  PubMed  PubMed Central  Google Scholar 

  89. Calvo FA, Micaily B, Brady LW (1993) Intra operative radiotherapy: a positive view. Am J Clin Oncol 16:418–423

    Article  CAS  PubMed  Google Scholar 

  90. Orecchia R, Ciocca M, Lazzari R et al (2003) Intraoperative radiation therapy with electrons (ELIOT) in early-stage breast cancer. Breast 12:483–490

    Article  CAS  PubMed  Google Scholar 

  91. Veronesi U, Orecchia R, Luini A et al (2001) Focalised intraoperative irradiation after conservative surgery for early stage breast cancer. Breast 10:84–89

    Article  Google Scholar 

  92. Veronesi U, Orecchia R, Maisonneuve P et al (2013) Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 14:1269–1277

    Article  PubMed  Google Scholar 

  93. Patel RR, Becker SJ, Das RK et al (2007) A dosimetric comparison of accelerated partial breast irradiation techniques: multicatheter interstitial brachytherapy, three-dimensional conformal radiotherapy, and supine versus prone helical tomotherapy. Int J Radiat Oncol Biol Phys 68:935–942

    Article  PubMed  Google Scholar 

  94. Smith BD, Arthur DW, Buchholz TA et al (2009) Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys 74:987–1001

    Article  PubMed  Google Scholar 

  95. Antonucci JV, Wallace M, Goldstein NS et al (2009) Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up. Int J Radiat Oncol Biol Phys 74:447–452

    Article  PubMed  Google Scholar 

  96. Polgar C, Major T, Fodor J et al (2010) Accelerated partial breast irradiation using high-dose-rate interstitial brachytherapy: 12-year update of a prospective clinical study. Radiother Oncol 94:274–279

    Article  PubMed  Google Scholar 

  97. Vaidya JS, Joseph DJ, Tobias JS et al (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376:91–102

    Article  PubMed  Google Scholar 

  98. Veronesi U, Orecchia R, Luini A et al (2010) Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons. Breast Cancer Res Treat 124:141–151

    Article  PubMed  Google Scholar 

  99. Vicini F, Beitsch PD, Quiet CA et al (2008) Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer 112:758–766

    Article  PubMed  Google Scholar 

  100. Oliver M, Chen J, Wong E et al (2007) A treatment planning study comparing whole breast radiation therapy against conformal, IMRT and tomotherapy for accelerated partial breast irradiation. Radiother Oncol 82:317–323

    Article  PubMed  Google Scholar 

  101. Smith BD, Arthur DW, Buchholz TA (2009) Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). J Am Coll Surg 209:269–277

    Article  PubMed  Google Scholar 

  102. Chadha M, Yoon H, Feldman S et al (2009) Partial breast brachytherapy as the primary treatment for breast cancer diagnosed after mantle radiation therapy for Hodgkin's disease. Am J Clin Oncol 32:132–136

    Article  PubMed  Google Scholar 

  103. Intra M, Mattar D, Sangalli C et al (2011) Local therapy for breast cancer in malignant lymphoma survivors. Breast 20:99–103

    Article  Google Scholar 

  104. Intra M, Gatti G, Luini A et al (2002) Surgical technique of intraoperative radiotherapy in conservative treatment of limited-stage breast cancer. Arch Surg 137:737–740

    Article  PubMed  Google Scholar 

  105. Cox JD, Stetx J, Pajak TF (1995) Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31:1341–1346

    Article  CAS  PubMed  Google Scholar 

  106. Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. Wiley, New York

    Google Scholar 

  107. Gray RJ (1988) A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 16:1141–1154

    Article  Google Scholar 

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  1. Division of Breast Surgery, European Institute of Oncology, Milan, Italy

    Mattia Intra & Denise Mattar Fanianos

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  1. Mattia Intra
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  1. European Institutee of Oncology, Milan, Italy

    Umberto Veronesi

  2. European Institute of Oncology, Milan, Italy

    Aron Goldhirsch

  3. European Institute of Oncology, Milan, Italy

    Paolo Veronesi

  4. San Raffaele University and Research Hospital, Milano, Italy

    Oreste Davide Gentilini

  5. European Institute of Oncology, Milan, Italy

    Maria Cristina Leonardi

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Intra, M., Fanianos, D.M. (2017). Breast Cancer in Lymphoma Survivors. In: Veronesi, U., Goldhirsch, A., Veronesi, P., Gentilini, O., Leonardi, M. (eds) Breast Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-48848-6_30

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