Abstract
The discovery of lithium has important lessons for psychiatry at several levels: in relation to strategies for drug discovery, in understanding the bipolar phenotype, in how insight into lithium’s mechanism of action and unique pharmacology relates to its positive actions on the one hand and its adverse effects on the other. Lithium’s pharmacology remains of interest, and a lithium mimetic is overdue. All these elements continue to place lithium at the heart of future research in bipolar disorder, just as it has occupied this place in its past. Moreover, findings on neuroprotection may herald new future indications and applications.
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Goodwin, G.M. (2017). Lithium in the Twenty-First Century. In: Malhi, G., Masson, M., Bellivier, F. (eds) The Science and Practice of Lithium Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-45923-3_21
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DOI: https://doi.org/10.1007/978-3-319-45923-3_21
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