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Necrobiotic Disorders

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Atlas of Dermatology, Dermatopathology and Venereology

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Abstract

The entities within the unique category of necrobiotic disorders have granuloma formation associated with necrobiosis as their common feature. “Necrobiosis” is generally defined as “cell death,” but in practical terms, it is translated to an amorphous appearance of affected tissues on microscopic examination. It has a close resemblance to another amorphous form of cell death, caseous necrosis, but the latter is more commonly applied to infectious diseases, particularly those lesions induced by Mycobacterium tuberculosis. In the conditions addressed in this chapter, infectious factors are not included. Instead, entities such as disorders secondary to small cutaneous vessels’ involvement (granuloma annulare and rheumatoid nodule) or alterations in keratin and sebum (lupus miliaris disseminatus faciei) are included.

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References

  • Alirezaei P, Farshchian M (2017) Granuloma annulare: relationship to diabetes mellitus, thyroid disorders and tuberculin skin test. Clin Cosmet Investig Dermatol 10:141–145

    Article  PubMed  PubMed Central  Google Scholar 

  • Amiruddin D, Mii S, Fujimura T, Katsuoka K (2011) Clinical evaluation of 35 cases of lupus miliaris disseminatus faciei. J Dermatol 38(6):618–620

    Article  PubMed  Google Scholar 

  • Bennett GA (1943) Comparison of the pathology of rheumatic fever and rheumatoid arthritis. Ann Intern Med 19(1):111–113

    Article  Google Scholar 

  • Bennett GA, Zeller J, Bauer W (1940) Subcutaneous nodules of rheumatoid arthritis and rheumatic fever. Arch Pathol 30:70–89

    Google Scholar 

  • Berbis P, Privat Y (1987) Lupus miliaris disseminatus faciei: efficacy of isotretinoin. JAAD 16(6):1271–1272

    Article  CAS  PubMed  Google Scholar 

  • Borhan R, Vignon-Pennamen MD, Morel P (2005) Lupus miliaris disseminatus faciei: 6 cases. Ann Dermatol Venereol 132(6–7 Pt 1):526–530

    Article  CAS  PubMed  Google Scholar 

  • Carapetis JR, McDonald M, Wilson NJ (2005) Acute rheumatic fever. Lancet 366(9480):155–168

    Article  PubMed  Google Scholar 

  • Choi JY, Chae SW, Park JH (2016) Lupus miliaris disseminatus faciei with extrafacial involvement. Ann Dermatol 28(6):791–794

    Article  PubMed  PubMed Central  Google Scholar 

  • Chopra P, Narula J, Tandon R (1991) Ultrastructure of naturally occurring subcutaneous nodule in acute rheumatic fever. Int J Cardiol 30(1):124–127

    Article  CAS  PubMed  Google Scholar 

  • Cominos D, Strutton G, Busmanis I (1993) Granulomas associated with tetanus toxoid immunization. Am J Dematopathol 15(2):114–117

    Article  CAS  Google Scholar 

  • Edwards LR, Kidd LL, Gru AA, Wilson BB (2017) Image gallery: Necrobiotic xanthogranuloma in association with chronic myelomonocytic leukaemia. Br J Dermatol 176(2):e16

    Article  CAS  PubMed  Google Scholar 

  • Erfurt-Berge C, Dissemond J, Schwede K, Seitz AT, Al Ghazal P, Wollina U, Renner R (2015) Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. Eur J Dermatol 25(6):595–601

    CAS  PubMed  Google Scholar 

  • Gunes P, Goktay F, Mansur AT, Koker F, Erfan G (2009) Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases. J Cutan Pathol 36(8):838–844

    Article  PubMed  Google Scholar 

  • Halder RM (1988) Pseudofolliculitis barbae and related disorders. Dermatol Clin 6(3):407–412

    Article  CAS  PubMed  Google Scholar 

  • Hayes RM, Gibson S (1942) An evaluation of rheumatic nodules in children. JAMA 119(7):554–555

    Article  Google Scholar 

  • Higgins LS, Go RS, Dingli D, Kumar SK, Rajkumar SV, Dispenzieri A, Buadi FK, Lacy MQ, Lust JA, Kapoor P, Leung N, Lin Y, Kourelis TV, Gertz MA, Kyle RA, Gonsalves WI (2016) Clinical features and treatment outcomes of patients with necrobiotic xanthogranuloma associated with monoclonal gammopathies. Clin Lymphoma Myeloma Leuk 16(8):447–452

    Article  PubMed  Google Scholar 

  • Khan F, Ramirez-Fort MK, Chan CS, Rosen T (2013) Hyperkeratotic necrobiosis lipoidica. Dermatol Pract Concept 3(1):13–15

    Article  PubMed  PubMed Central  Google Scholar 

  • Kossard S, Winkelmann RK (1980) Necrobiotic xanthogranuloma with paraproteinemia. J Am Acad Dermatol 3(3):257–270

    Article  CAS  PubMed  Google Scholar 

  • Lee JM, Kim YJ (2015) Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg 42(2):232–239

    Article  PubMed  PubMed Central  Google Scholar 

  • Marcus V, Roy I, Sullivan J, Sutton J (1997) Necrobiotic palisading granulomas involving bone and joint: report of two cases. Am J Surg Pathol 21(5):563–565

    Article  CAS  PubMed  Google Scholar 

  • Mehregan DA, Winkelmann RK (1992) Necrobiotic xanthogranuloma. Arch Dermatol 128(1):94–100

    Article  CAS  PubMed  Google Scholar 

  • Miguel D, Lukacs J, Illing T, Elsner P (2017) Treatment of necrobiotic xanthogranuloma – a systematic review. J Eur Acad Dermatol Venereol 31(2):221–235

    Article  CAS  PubMed  Google Scholar 

  • Miyasaka N, Sata K, Yamamoto K, Goto M, Nishioka K (1989) Immunological and immunohistochemical analysis of rheumatoid nodules. Ann Rheum Dis 48(3):220–226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mortimer E, Vaisman S, Vigneau A, Guasch J, Schuster A, Rakita L, Krause RM, Roberts R, Rammelkamp CH Jr (1959) The effect of penicillin on acute rheumatic fever and valvular heart disease. N Engl J Med 260(3):101–112

    Article  PubMed  Google Scholar 

  • Mullan E, Green P, Pasternak S (2011) Lupus miliaris disseminatus faciei with extrafacial involvement in a 17-year-old white girl. J Cutan Med Surg 15(6):340–343

    Article  PubMed  Google Scholar 

  • Patterson JW (1988) Rheumatoid nodule and subcutaneous granuloma annulare. A comparative histologic study. Am J Dermatopathol 10(1):1–8

    Article  CAS  PubMed  Google Scholar 

  • Peckruhn M, Tittelbach J, Elsner P (2017) Update: treatment of necrobiosis lipoidica. J Dtsch Dermatol Ges 15(2):151–157

    PubMed  Google Scholar 

  • Sardana K, Chugh S, Ranjan R, Khurana N (2017) Lupus miliaris disseminatus faciei: a resistant case with response to cyclosporine. Dermatol Ther 30(4):e12496

    Article  Google Scholar 

  • Sehgal VN, Srivastava G, Aggarwal AK, Belum VR, Sharma S (2005) Lupus miliaris disseminatus faciei. Part I: significance of histopathologic undertones in diagnosis. Skinmed 4(3):151–156

    Article  PubMed  Google Scholar 

  • Sperling B, Bachmann F, Hartmann V, Erdmann R, Wiest L, Rzany B (2010) The current state of treatment of adverse reaction to injectable fillers. Dermatol Surg 36(suppl 3):1895–1904

    Article  CAS  PubMed  Google Scholar 

  • Spicknall KE, Mehregan DA (2009) Necrobiotic xanthogranuloma. Int J Dermatol 48(1):1–10

    Article  PubMed  Google Scholar 

  • Thornsberry LA, English JC 3rd (2013) Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. Am J Clin Dermatol 14(4):279–290

    Article  PubMed  Google Scholar 

  • Toro JR, Chu P, Yen TS, LeBoit PE (1999) Granuloma annulare and human immunodeficiency virus infection. Arch Dermatol 135(11):1341–1346

    Article  CAS  PubMed  Google Scholar 

  • Veys E, De Keyser F (1993) Rheumatoid nodules: differential diagnosis and immunohistological findings. Ann Rheum Dis 52(9):625–626

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wallet-Faber N, Farhi D, Gorin I, Carlotti A, Plantier F, Dupin N, Avril MF (2010) Outcome of granuloma annulare: shorter duration is associated with younger age and recent onset. J Eur Acad Dermatol Venereol 24(1):103–104

    Article  CAS  PubMed  Google Scholar 

  • Ziff M (1990) The rheumatoid nodule. Arthritis Rheum 33(6):761–767

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA

    James W. Patterson

  2. Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA

    James W. Patterson

  3. Clinical Assistant Professor of Pathology, University of Kansas Medical Center, Kansas, Kansas, USA

    Hongyan Dai

  4. Dermatopathologist, Walter Reed Army Medical Center, Fort Belvoir, Virginia, USA

    Patrick J. Voorhees

Authors
  1. James W. Patterson
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  2. Hongyan Dai
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  3. Patrick J. Voorhees
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Correspondence to James W. Patterson .

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Editors and Affiliations

  1. Department of Pathology, Univ of Rochester School of Med, Rochester, NY, USA

    Bruce Smoller

  2. Khorramshahr, Iran

    Nooshin Bagherani

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Patterson, J.W., Dai, H., Voorhees, P.J. (2019). Necrobiotic Disorders. In: Smoller, B., Bagherani, N. (eds) Atlas of Dermatology, Dermatopathology and Venereology . Springer, Cham. https://doi.org/10.1007/978-3-319-45134-3_46-1

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  • DOI: https://doi.org/10.1007/978-3-319-45134-3_46-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45134-3

  • Online ISBN: 978-3-319-45134-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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