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Hematopoietic Stem Cell Aging and Malignant Hemopathies

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Geriatric Oncology

Abstract

The probability of developing cancer, primarily malignant hemopathies, increases with age. This complex relationship between cancer and aging has been extensively studied; cellular senescence, a protective mechanism in response to DNA damage, can induce permanent growth arrest and resistance to apoptosis. Chronological age also favors the accumulation of genetic and epigenetic changes that are important contributing factors in the complex pathogenesis of cancer. Indeed recent studies have highlighted the role of epigenetics and, in particular, a decline in heterochromatin integrity as important factors contributing to the loss of and stem cell function during HSC aging and in premature aging syndromes. Furthermore, impairment of cancer prevention pathways and the clonal restriction of hematopoietic stem cells observed with age may also contribute to the increased frequency of malignant transformation. However, at present our understanding of the process of aging is far from complete, and many open questions are currently under investigation. This chapter will focus on the complex multistep interplay between aging and the higher incidence of malignant hemopathies.

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Authors and Affiliations

  1. INSERM UMRS1126, Hôpital Saint Louis, Paris, France

    Michele Goodhardt & David Garrick

  2. Department of Hematology, Institut Jules Bordet (ULB), Brussels, Belgium

    Luan Dang, Adriano Salaroli & Dominique Bron

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  1. Michele Goodhardt
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  2. David Garrick
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  3. Luan Dang
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  4. Adriano Salaroli
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  5. Dominique Bron
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Correspondence to Dominique Bron .

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  1. Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA

    Martine Extermann

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  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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© 2018 Springer International Publishing AG

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Goodhardt, M., Garrick, D., Dang, L., Salaroli, A., Bron, D. (2018). Hematopoietic Stem Cell Aging and Malignant Hemopathies. In: Extermann, M. (eds) Geriatric Oncology . Springer, Cham. https://doi.org/10.1007/978-3-319-44870-1_71-1

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  • DOI: https://doi.org/10.1007/978-3-319-44870-1_71-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-44870-1

  • Online ISBN: 978-3-319-44870-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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