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Luteal Angiogenesis

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The Life Cycle of the Corpus Luteum

Abstract

The structure and function of the corpus luteum (CL) is dependent on the development of an intricate vasculature via the process of angiogenesis. The establishment of the luteal vascular network begins in the preovulatory follicle and is ultimately stimulated by the luteinizing hormone (LH) surge. Following ovulation, the corpus luteum undergoes extremely rapid growth and intense angiogenesis that is tightly regulated by a balance achieved between pro-angiogenic and anti-angiogenic factors. This review summarizes what is known about the critical control of luteal angiogenesis and the complex interplay between numerous factors, the functions of which are only just beginning to be elucidated.

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Acknowledgments

This work has been funded by BBSRC, Pfizer and University of Nottingham. We greatly appreciate the technical assistance of staff at the University of Nottingham without which this work would not have been possible.

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  1. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK

    Robert S. Robinson & Kathryn J. Woad

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Correspondence to Robert S. Robinson .

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  1. The Robert H. Smith Faculty of Agriculture Food and Environment Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Jerusalem, Israel

    Rina Meidan

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Robinson, R.S., Woad, K.J. (2017). Luteal Angiogenesis. In: Meidan, R. (eds) The Life Cycle of the Corpus Luteum. Springer, Cham. https://doi.org/10.1007/978-3-319-43238-0_1

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