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Epidemiology and Histopathology: Penile Cancer

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Book cover Urologic Oncology

Abstract

Penile carcinoma are rare, the vast majority are squamous cell carcinomas, they mainly occur in the squamous epithelium of the glans, sulcus and the foreskin. The WHO 2016 classification has introduced changes and redefined the prognostic value of the different subtypes of squamous cell carcinomas. Some of them, such as the verrucous carcinoma, have better outcome. Therefore it is important for the clinicians to know the prognostic value of these tumors, but it is also of major impact to classify from a pathology point of view the different types.

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References

  • Barnes KT, Smith BJ, Lynch CF, Gupta A. Obesity and invasive penile cancer. Eur Urol. 2013;63:588–9.

    Article  Google Scholar 

  • Barnes KT, McDowell BD, Button A, Smith BJ, Lynch CF, Gupta A. Obesity is associated with increased risk of invasive penile cancer. BMC Urol. 2016;16(1):42.

    Article  Google Scholar 

  • Barreto JE, Velazquez EF, Ayala E, Torres J, Cubilla AL. Carcinoma cuniculatum: a distinctive variant of penile squamous cell carcinoma: report of 7 cases. Am J Surg Pathol. 2007;31(1):71–5.

    Article  Google Scholar 

  • Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL. Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases. Am J Surg Pathol. 2009;33(9):1299–306.

    Article  Google Scholar 

  • Chaux A, Tamboli P, Ayala A, Soares F, Rodríguez I, Barreto J, Cubilla AL. Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases. Mod Pathol. 2010;23(6):896–904.

    Article  Google Scholar 

  • Chaux A, Pfannl R, Rodríguez IM, Barreto JE, Velazquez EF, Lezcano C, Piris A, Netto GJ, Cubilla AL. Distinctive immunohistochemical profile of penile intraepithelial lesions: a study of 74 cases. Am J Surg Pathol. 2011;35(4):553–62.

    Article  Google Scholar 

  • Chaux A, Velazquez EF, Amin A, Soskin A, Pfannl R, Rodríguez IM, Barreto JE, Lezcano C, Ayala G, Netto GJ, Cubilla AL. Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients. Hum Pathol. 2012a;43(7):1020–7.

    Article  Google Scholar 

  • Chaux A, Velazquez EF, Barreto JE, Ayala E, Cubilla AL. New pathologic entities in penile carcinomas: an update of the 2004 world health organization classification. Semin Diagn Pathol. 2012b;29(2):59–66.

    Article  Google Scholar 

  • Cubilla AL, Velazques EF, Reuter VE, Oliva E, Mihm MC Jr, Young RH. Warty (condylomatous) squamous cell carcinoma of the penis: a report of 11 cases and proposed classification of 'verruciform' penile tumors. Am J Surg Pathol. 2000;24(4):505–12.

    Article  CAS  Google Scholar 

  • Cubilla AL, Reuter V, Velazquez E, Piris A, Saito S, Young RH. Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol. 2001;9(2):111–20.

    Article  CAS  Google Scholar 

  • Cunha IW, Guimaraes GC, Soares F, Velazquez E, Torres JJ, Chaux A, Ayala G, Cubilla AL. Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients. Am J Surg Pathol. 2009;33(4):551–5.

    Article  Google Scholar 

  • Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ. The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J Urol. 1995;154(3):1024–9.

    Article  CAS  Google Scholar 

  • Daling J, Madeleine M, Johnson L, et al. Penile cancer: importance of circumcision, HPV and smoking in in situ and invasive disease. Int J Cancer. 2005;116:606–16.

    Article  CAS  Google Scholar 

  • Gregoire L, Cubilla AL, Reuter VE, Haas GP, Lancaster WD. Preferential association of human papillomavirus with high-grade histologic variants of penile-invasive squamous cell carcinoma. J Natl Cancer Inst. 1995;87(22):1705–9.

    Article  CAS  Google Scholar 

  • Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol. 2009;182(2):528–34.

    Article  Google Scholar 

  • Manipadam MT, Bhagat SK, Gopalakrishnan G, Kekre NS, Chacko NK, Prasanna S. Warty carcinoma of the penis: a clinicopathological study from South India. Indian J Urol. 2013;29(4):282–7.

    Article  Google Scholar 

  • Mentrikoski MJ, Frierson HF Jr, Stelow EB, Cathro HP. Lymphoepithelioma-like carcinoma of the penis: association with human papilloma virus infection. Histopathology. 2014;64(2):312–5.

    Article  Google Scholar 

  • Moch H, et al. WHO classification of tumours of the urinary system and male genital organs. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2016. http://enup.org/4th-edition-classification-tumours-urinary-system-male-genital-organs/

    Google Scholar 

  • Romero FR, de Castro MG, Garcia CR, Perez MD. Adenosquamous carcinoma of the penis. Clinics (Sao Paulo). 2006;61(4):363–4.

    Article  Google Scholar 

  • Sanchez DF, Rodriguez IM, Piris A, Cañete S, Lezcano C, Velazquez EF, Fernandez-Nestosa MJ, Mendez-Pena JE, Hoang MP, Cubilla AL. Clear cell carcinoma of the penis: an HPV-related variant of squamous cell carcinoma: a report of 3 cases. Am J Surg Pathol. 2016;40(7):917–22.

    Article  Google Scholar 

  • Siegal R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.

    Article  Google Scholar 

  • Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM. HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis. Mod Pathol. 2009;22(9):1160–8.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Hôpital Tenon, HUEP, UPMC Paris VI, Sorbonne Universities, Paris, France

    Eva Compérat

Authors
  1. Eva Compérat
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Corresponding author

Correspondence to Eva Compérat .

Editor information

Editors and Affiliations

  1. Urologie, Univ Lübeck, Lübeck, Schleswig-Holstein, Germany

    Axel Merseburger

  2. Dept. of Urology, University of Regensburg St. Josef Medical Centre, Regensburg, Germany

    Maximilian Burger

Section Editor information

  1. Universitätsklinikum Rostock , Urologische Klinik und Poliklinik, Rostock, Germany

    Chris Protzel

  2. Division of Oncological Urology, Department of Urology, University of Köln, Köln, Germany

    Axel Heidenreich

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Compérat, E. (2019). Epidemiology and Histopathology: Penile Cancer. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42603-7_33-1

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  • DOI: https://doi.org/10.1007/978-3-319-42603-7_33-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42603-7

  • Online ISBN: 978-3-319-42603-7

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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