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Coenzyme Q10 in Male Infertility

Coenzyme Q10

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Antioxidants in Andrology

Part of the book series: Trends in Andrology and Sexual Medicine ((TASM))

Abstract

This chapter deals with the role of coenzyme Q10 in male infertility in the light of the increasing evidence of oxidative damage and antioxidant defence in sperm cells and seminal plasma. Reactive oxygen species have a key pathogenetic role in male infertility as well as a well-recognized physiological function. The involvement of coenzyme Q10 in mitochondrial bioenergetics and its antioxidant properties are at the basis of its role in seminal fluid. Therefore, in this chapter, we present the physiopathological basis linking coenzyme Q10 and its therapeutical properties. In addition, we provide an updated discussion of the clinical studies assessing the therapeutical effects of coenzyme Q10.

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References

  1. Alvarez JG, Storey B. Spontaneous lipid peroxidation in rabbit epididymal spermatozoa: its effect on sperm motility. Biol Reprod. 1982;27:1102–8.

    Article  CAS  PubMed  Google Scholar 

  2. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil. 1987;81:459–69.

    Article  CAS  PubMed  Google Scholar 

  3. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol Reprod. 1989;40:183–97.

    Article  Google Scholar 

  4. Rao B, Soufir JC, Martin M, David G. Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res. 1989;24:127–34.

    Article  CAS  PubMed  Google Scholar 

  5. Suleiman SA, Ali ME, Zaki ZM, El-Malik EM, Nasr MA. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996;17:530–7.

    CAS  PubMed  Google Scholar 

  6. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction. 2001;122:497–06.

    Article  CAS  PubMed  Google Scholar 

  7. Aitken RJ, Baker MA. Reactive oxygen species generation by human spermatozoa: a continuing enigma. Int J Androl. 2002;25:191–4.

    Article  PubMed  Google Scholar 

  8. Balercia G, Moretti S, Vignini A, Magagnini M, Mantero F, Boscaro M, et al. Role of nitric oxide concentration on human sperm motility. J Androl. 2004;25:245–9.

    Article  CAS  PubMed  Google Scholar 

  9. Winston GW, Regoli F, Dugas Jr AJ, Fong JH, Blanchard KA. A rapid chromatographic assay for determining oxyradical scavenging capacity of antioxidants and biological fluids. Free Radic Biol Med. 1998;24:480–93.

    Article  CAS  PubMed  Google Scholar 

  10. Regoli F, Winston GW. Quantification of total antioxidant scavenging capacity (TOSC) of antioxidants for peroxynitrite, peroxyl radicals and hydroxyl radicals. Toxicol Appl Pharmacol. 1999;156:96–105.

    Article  CAS  PubMed  Google Scholar 

  11. Balercia G, Mantero F, Armeni T, Principato G, Regoli F. Oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. A possible influence on kinetic parameters. Clin Chem Lab Med. 2003;41:13–9.

    Article  CAS  PubMed  Google Scholar 

  12. Mancini A, Meucci E, Bianchi A, Milardi D, De Marinis L, Littarru GP. Antioxidant systems in human seminal plasma: physiopathological meaning and new perspectives. In: Panglossi HV, editor. New perspective in antioxidant research. New York: Nova Science Pub; 2006. p. 131–47.

    Google Scholar 

  13. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20(6):591–8.

    Article  CAS  PubMed  Google Scholar 

  14. Kaltschmidt B, Sparna T, Kaltschmidt C. Activation of NFkB by reactive oxygen intermediates in the nervous system. Antioxid Redox Signal. 1999;1:129–44.

    Article  CAS  PubMed  Google Scholar 

  15. Crane FL, Navas P. The diversity of coenzyme Q function. Mol Aspects Med. 1997;18:s1–6.

    Article  CAS  PubMed  Google Scholar 

  16. Sun IL, Sun EE, Crane FL. Comparison of growth stimulation of HeLa cells, HL-60 cells and mouse fibroblasts by coenzyme Q. Protoplasma. 1995;184:214–9.

    Article  CAS  Google Scholar 

  17. Sun IL, Sun EE, Crane FL, Morrè DJ, Lindgren A, Low H. A requirement for coenzyme Q in plasma membrane electron transport. Proc Natl Acad Sci U S A. 1990;89:11126–30.

    Article  Google Scholar 

  18. Thomas SR, Witting PK, Stocker R. A role for reduced coenzyme Q in atherosclerosis? Biofactors. 1999;9:207–24.

    Article  CAS  PubMed  Google Scholar 

  19. Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1646–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247–54.

    Article  CAS  PubMed  Google Scholar 

  21. Yalcin A, Kilinc E, Sagcan A, Kultursay H. Coenzyme Q10 concentrations in coronary artery disease. Clin Biochem. 2004;37:706–9.

    Article  CAS  PubMed  Google Scholar 

  22. Mancini A, Leone E, Festa R, Grande G, Silvestrini A, De Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E. Effects of testosterone on antioxidant systems in male secondary hypogonadism. J Androl. 2008;29(6):622–9. [E-pub 2008 Jul 17].

    Article  CAS  PubMed  Google Scholar 

  23. Mancini A, Leone E, Silvestrini A, Festa R, Di Donna V, De Marinis L, Pontecorvi A, Littarry GP, Meucci E. Evaluation of antioxidant systems in pituitary-adrenal axis diseases, Pituitary. Heidelberg/New York: Springer [E-pub 2009 Dec 12].

    Google Scholar 

  24. Hughes K, Lee BL, Feng X, Lee J, Ong CN. Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese. Free Radic Biol Med. 2002;32(2):132–8.

    Article  CAS  PubMed  Google Scholar 

  25. Mancini A, Festa R, Di Donna V, Leone E, Littarru GP, Silvestrini A, Meucci E, Pontecorvi A. Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes. J Endocrinol Invest. 2010;33:422–33.

    Article  CAS  PubMed  Google Scholar 

  26. Mancini A, Festa R, Silvestrini A, Nicolotti N, Di Donna V, La Torre G, Pontecorvi A, Meucci E. Hormonal regulation of total antioxidant capacity in seminal plasma. J Androl USA. 2009;30 (5):534–540. [E-pub 2009 Feb 19].

    Google Scholar 

  27. Mancini A, Raimondo S, Persano M, Di Segni C, Cammarano M, Gadotti G, Silvestrini A, Pontecorvi A, Meucci E. Estrogens as antioxidant modulators in human fertility. Int J Endocrinol. (2013):607939. doi:10.1155//2013/607939. [E pub 2013 Nov 20].

  28. Fawcett DW. The mammalian spermatozoon. Dev Biol. 1975;44:394–436.

    Article  CAS  PubMed  Google Scholar 

  29. Kalen A, Appelkvist EL, Chojnacki T, Dallner G. Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis in endoplasmic reticulum-Golgi system of rat liver. J Biol Chem. 1990;265:1158–64.

    CAS  PubMed  Google Scholar 

  30. Mazzilli F, Cerasaro M, Bisanti A, Rossi T, Dondero F. Seminal parameters and the swelling test in patients with sperm before and after treatment with ubiquinone (CoQ10). 2nd International symposium on reproductive medicine, Fiuggi, Rome. Acta Medica, Edizioni e Congressi, 1988, p. 71.

    Google Scholar 

  31. Mazzilli F, Bisanti A, Rossi T, DeSantis L, Dondero F. Seminal and biological parameters in dysspermic patients with sperm hypomotility before and after treatment with ubiquinone (CoQ10). J Endocrinol Invest 13S1. 1990;88.

    Google Scholar 

  32. Mancini A, De Marinis L, Oradei A, Hallgass ME, Conte G, Pozza D, Littarru GP. Coenzyme Q10 concentrations in normal and pathological human seminal fluid. J Androl. 1994;15:591–4.

    CAS  PubMed  Google Scholar 

  33. Mancini A, Milardi D, Conte G, Bianchi A, Balercia G, De Marinis L, Littarru GP. Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients. Metabolism. 2003;52:402–6.

    Article  CAS  PubMed  Google Scholar 

  34. Angelitti AG, Colacicco L, Callà C, Arizzi M, Lippa S. Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa. Clin Chem. 1995;41:217–9.

    CAS  PubMed  Google Scholar 

  35. Mancini A, Conte G, De Marinis L, Hallgass ME, Pozza D, Oradei A, Littarru GP. Coenzyme Q10 levels in human seminal fluid: diagnostic and clinical implications. Mol Aspects Med. 1994;15:s249–55.

    Article  PubMed  Google Scholar 

  36. Littarru GP, Lippa S, Oradei A, Fiorini RM, Mazzanti L. Metabolic and diagnostic implications of human blood CoQ10 levels. In: Folkers K, Littarru GP, Yamagami T, editors. Biomedical and clinical aspects of coenzyme Q, vol. 6. Amsterdam: Elsevier; 1991. p. 167–78.

    Google Scholar 

  37. Mancini A, Conte G, Milardi D, De Marinis L, Littarru GP. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. Andrologia. 1998;30:1–4.

    Article  CAS  PubMed  Google Scholar 

  38. Mancini A, Milardi D, Conte G, Festa R, De Marinis L, Littarru GP. Seminal antioxidants in humans: preoperative and postoperative evaluation of Coenzyme Q10 in varicocele patients. Horm Metab Res. 2005;37:428–32.

    Article  CAS  PubMed  Google Scholar 

  39. Mostafa T, Anis TH, El-Nashar A, Imam H, Othman IA. Varicocelectomy reduces reactive oxygen species levels and increases antioxidant attività of seminal plasma from infertile men with varicocele. Int J Androl. 2001;24:261–5.

    Article  CAS  PubMed  Google Scholar 

  40. Meucci E, Milardi D, Mordente A, Martorana GE, Giacchi E, De Marinis L, Mancini A. Total antioxidant capacity in patients with varicocele. Fertil Steril. 2003;79:1577–83.

    Article  PubMed  Google Scholar 

  41. A. Mancini, D. Milardi, R. Festa, G. Balercia, L. De Marinis, A. Pontecorvi, F. Principi, G.P. Littarru. Seminal CoQ10 and male infertility: effects of medical or surgical treatment on endogenous seminal plasma concentrations. Abstracts of the 4th international coenzyme Q10 association, Los Angeles, April 14–17, 2005, p. 64–5.

    Google Scholar 

  42. Eroglu M, Sahin S, Durukan B, Ozakpinar OB, Erdinc N, Tiurkgeldi L, Sofuoglu K, Karateke A. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res. 2014;159:46–51.

    Article  CAS  PubMed  Google Scholar 

  43. Gvozdjakova A, Kucharska J, Dubravic J, Mojto V, Singh RB. Coenzyme Q10, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility. Disease Markers. 2015;ID 827941 1-6.

    Google Scholar 

  44. Alleva R, Scaramucci A, Mantero F, Bompadre S, Leoni L, Littarru GP. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Mol Aspects Med. 1997;18:s221–8.

    Article  CAS  PubMed  Google Scholar 

  45. Balercia G, Arnaldi G, Fazioli F, Serresi M, Alleva R, Mancini A, Mosca F, Lamonica GR, Mantero F, Littarru GP. Coenzyme Q10 levels in idiopathic and varicocele-associated asthenozoospermia. Andrologia. 2002;34:107–11.

    Article  CAS  PubMed  Google Scholar 

  46. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005;8:641–6.

    Article  CAS  PubMed  Google Scholar 

  47. Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med. 1997;18:s213–9.

    Article  CAS  PubMed  Google Scholar 

  48. Balercia G, Mantero F, Armeni T, Principato G, Regoli F. Oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. A possible influence on kinetic parameters. Clin Chem Lab Med. 2003;41:13–9.

    Article  CAS  PubMed  Google Scholar 

  49. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, Littarru GP. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004;81:93–8.

    Article  CAS  PubMed  Google Scholar 

  50. World Health Organization (WHO). Laboratory manual for the examination of human semen and semen-cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press; 1999.

    Google Scholar 

  51. Frei B, Yamamoto Y, Niclas D, Ames BN. Evaluation of an isoluminol chemiluminescence assay for detection of hydroperoxides in human blood plasma. Ann Biochem. 1998;175:120–30.

    Article  Google Scholar 

  52. Langsjoen P, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med. 1997;8:145–51s.

    Google Scholar 

  53. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, Ricciardo-Lamonica G, Boscaro M, Lenzi A, Littarru GP. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2009;91:1785–92. Bremer J. Carnitine-metabolism and functions. Physiol Rev. 1983;63:1420–80.

    Google Scholar 

  54. Festa R, Giacchi E, Raimondo S, Tiano L, Zuccarelli P, Silvestrini A, E.E. M, G.P. L, Mancini A. Coenzyme Q10 supplementation in infertile men with low-grade varicocele : an open, uncontrolled pilot study. Andrologia. 2013;46:805–7. doi:10.1111/and.12152. [E-pub 2013 Aug 22].

    Article  PubMed  Google Scholar 

  55. Cakiroglu B, Eyyupoglu SE, Gozukucuk R, Uyanik BS. Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephro Urol Mon. 2014;6:e16870.

    Article  Google Scholar 

  56. Lafuente R, Gonzalez-Comadran M, Solà I, Lopez G, Brassesco M, Carreras R, Checa MA. Coenzyme Q10 and male infertility : a meta-analysis. J Assist Reprod Genet. 2011;30:1147–56.

    Article  Google Scholar 

  57. Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol. 2009;182:237–48.

    Article  CAS  PubMed  Google Scholar 

  58. Nadjarzadeh A, Sadeghi MR, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Coenzyme Q10 improves seminal oxidative defence but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J Endocrinol Invest. 2011:e224–8.

    Google Scholar 

  59. Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, El-Toukhy T. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online. 2010;20:711–23. [E-pub 2010 Mar 10].

    Article  CAS  PubMed  Google Scholar 

  60. Lanzafame FM, La Vignera S, Vicari E, Calogero AE. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online. 2009;19:638–59.

    Article  CAS  PubMed  Google Scholar 

  61. Clark NA, Will M, Moravek MB, Fiseha S. A systematic review of the evidence for complementary and alternative medicine in infertility. Int J Gynaecol Obstet. 2013;122:202–6.

    Article  PubMed  Google Scholar 

  62. Walczak-Jedrzejowska R, Wolski JK, Slowikowska-Hilczer J. The role of oxidative stress and antioxidants in male fertility. Cent Eur J Urol. 2013;66:60–7. [E-pub 2013 Apr 26].

    Article  CAS  Google Scholar 

  63. Arcaniolo D, Favilla V, Tiscione D, Pisano F, Bozzini G, Creta M, Gentile G, Menchini FF, Pavan N, Veneziano IA, Cai T, on behalf of Young Commission of Italian Andrological Society. Arch It Urol Androl. 2014;86:164–70.

    Article  CAS  Google Scholar 

  64. D’Aniello G, Ronsini S, Notari T, Grieco N, Infante V, D’Angelo N, Mascia F, Di Fiore MM, Fisher G, D’Aniello A. D-aspartate, a key element for the improvement of sperm quality. Adv Sex Med. 2012;2:47–53.

    Google Scholar 

  65. Rathore MS, Gupta VB. Protective effect of amino acids on eye lenses against oxidative stress induced by hydrogen peroxide. As J Pharmac Clin Res. 2010;3:166–9.

    CAS  Google Scholar 

  66. Tirabassi G, Vignini A, Tiano L, Buldreghini E, Brugè F, Silvestri S, Orlando P, D’Aniello A, Mazzanti L, Lenzi A, Balercia G. Protective effects of coenzyme Q10 and aspartic acid on oxidative stress and DNA damage in subjects affected by idiopathic asthenozoospermia. Endocrine. 2015;(49):549–52. doi:10.3109/09537104.2014.980797. [E-pub 2014 Nov 10].

  67. Talevi R, Barbato V, Fiorentino L, Braun S, Longobardi S, Gualtieri R. Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme Q10 on human sperm motility, lipid peroxidation and DNA fragmentation. Reprod Biol Endocrinol. 2013;11:81. doi:10.1186/1477-7827-11-81.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Abad C, Amengual MJ, Gosalvez J, Coward K, Hannaoui N, Benet J, Garcia-Peirò A, Prats J. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia. 2013;45:211–6.

    Article  CAS  PubMed  Google Scholar 

  69. Gual-Frau J, Abad C, Amengual MJ, Hannaoui N, Checa MA, Ribas-Maynou J, Lozano I, Nikolaou A, Benet J, Garcia-Peirò A, Prats J. Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grad I varicocele patients. Hum Fertil (Camb). 2015;18:225–9.

    Article  CAS  Google Scholar 

  70. Kobori Y, Ota S, Sato R, Yagi H, Soh S, Arai G, Okada H. Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia. Arch It Urol Androl. 2014;86:1–4.

    Article  Google Scholar 

  71. Fato R, Cavazzoni M, Castelluccio C, Parenti Castelli G, Lenaz G. Steady state kinetics of ubiquinol-cytochrome c reductase in bovine heart submitochondrial particles: diffusional effects. Biochem J. 1993;290:225–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Kelso KA, Redpath A, Noble RC, Speake BK. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. J Reprod Fertil. 1997;109:1–6.

    Article  CAS  PubMed  Google Scholar 

  73. Jeulin C, Lewin LM. Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update. 1996;2:87–102.

    Article  CAS  PubMed  Google Scholar 

  74. Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro M. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril. 2005;84:662–71.

    Article  CAS  PubMed  Google Scholar 

  75. Costa M, Canale D, Filicori M, D'Iddio S, Lenzi A. L-Carnitine in idiopathic asthenozoospermia: a multicenter study. Andrologia. 1994;26:155–9.

    Article  CAS  PubMed  Google Scholar 

  76. Vicari E, Calogero AE. Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Hum Reprod. 2001;16:2338–42.

    CAS  PubMed  Google Scholar 

  77. Vicari E, La Vignera S, Calogero AE. Antioxidant treatment with carnitine is effective in infertile patients with prostato-vesiculo-epididymitis and elevated seminal leukocyte concentration after treatment with nonsteroidal anti-inflammatory compounds. Fertil Steril. 2002;78:1203–8.

    Article  PubMed  Google Scholar 

  78. Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L, Dondero F, et al. Use of carnitine therapy in selected cases of male factor infertility: a double blind cross-over trial. Fertil Steril. 2003;79:292–300.

    Article  PubMed  Google Scholar 

  79. Lenzi A, Sgrò P, Salacone P, Paoli D, Gilio B, Lombardo F, et al. Placebo controlled double blind randomised trial on the use of L-carnitine and L-acetyl-carnitine combined treatment in asthenozoospermia. Fertil Steril. 2004;81:1578–84.

    Article  CAS  PubMed  Google Scholar 

  80. Kobayashi A, Fujisawa S. Effect of L-carnitine on mitochondrial acyl-carnitine, acyl-coenzyme A and high energy phosphate in ischemic dog heart. J Mol Cell Cardiol. 1994;26:499–508.

    Article  CAS  PubMed  Google Scholar 

  81. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2011;(1):CD007411. doi: 10.1002/14651858.CD007411.pub2.

  82. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015;14:887–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Andrology Unit, Division of Endocrinology, Department of Clinical and Molecular Sciences, Via Conca 71, Umberto I Hospital, Polytechnic University of Marche, 60126, Ancona, Italy

    Giancarlo Balercia MD & Giacomo Tirabassi

  2. Endocrinology, Catholic University of the Sacred Heart, Rome, Italy

    Antonio Mancini & Alfredo Pontecorvi

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  1. Giancarlo Balercia MD
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  2. Antonio Mancini
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  3. Giacomo Tirabassi
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  4. Alfredo Pontecorvi
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Correspondence to Giancarlo Balercia MD .

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Editors and Affiliations

  1. Endocrinology Department, Polytechnic University of Marche, Ancona, Italy

    Giancarlo Balercia

  2. Department of Experimental Medicine Section of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy

    Loredana Gandini

  3. Department of Experimental Medicine Section of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy

    Andrea Lenzi

  4. Department of Experimental Medicine Section of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy

    Francesco Lombardo

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Balercia, G., Mancini, A., Tirabassi, G., Pontecorvi, A. (2017). Coenzyme Q10 in Male Infertility. In: Balercia, G., Gandini, L., Lenzi, A., Lombardo, F. (eds) Antioxidants in Andrology. Trends in Andrology and Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-41749-3_4

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