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Current Updates from the Long-Standing Phage Research Centers in Georgia, Poland, and Russia

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Bacteriophages

Abstract

The George Eliava Institute of Bacteriophages, Microbiology and Virology (IBMV) in Tbilisi, Georgia; the Hirszfeld Institute of Immunology and Experimental Therapy in Wroclaw, Poland; and various centers and companies in Russia, together, have a long history of clinical phage therapy use. With a revived interest in phage therapy, attention has turned to these long-standing centers and their wealth of hands-on experience. The Eliava Institute has been the leader in bacteriophage research and therapy since Soviet times. In accord with the growing antibiotic crisis, some of the important ongoing research at the Eliava Institute has focused on pathogens such as Acinetobacter, MRSA, and Pseudomonas. Genetic characterization of Georgian cocktails has supported their safety in clinical use. More recently, Georgian clinical research has focused on chronic wound, urological, and lung infections. The Eliava Phage Therapy Center is central to coordinating the expertise of Eliava scientists with the increasing demand for treatment of antibiotic-resistant infections with phage. The Hirszfeld Institute’s research has focused on expansion of their rich phage collection and development of optimized phage preparations including starting a collection of plasmid- and prophage-free hosts for phage stock preparation. Polish research has given some potential insight into important aspects of clinical tolerability, immunogenicity, and treatment of antibiotic-resistant infections. The Phage Therapy Unit of the Hirszfeld Institute has provided an in-depth analysis of clinical results through extensive observational studies. Bacteriophage preparations are registered medicines in Russia. Their use in clinical practice is well established, but there is no single center there dedicated to phage therapy. Multiple studies from different institutions focus on prophylactic use of phage for chronic conditions in the areas of ENT, gynecology, and urology. All of the research correlates with a positive tendency for phage therapy safety and efficacy. As there is an overwhelming need for effective alternatives to antibiotics, an important distinguishing aspect of phage therapy as just such an alternative is this ongoing and historical clinical use of phage therapy in these three countries, as reviewed in this chapter.

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Authors and Affiliations

  1. Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

    Ryszard Międzybrodzki, Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska & Andrzej Górski

  2. Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

    Ryszard Międzybrodzki, Beata Weber-Dąbrowska & Andrzej Górski

  3. Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland

    Ryszard Międzybrodzki, Jan Borysowski & Andrzej Górski

  4. Autonomous Department of Microbial Biology, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw, Poland

    Małgorzata Łobocka

  5. Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

    Małgorzata Łobocka

  6. Eliava Phage Therapy Center, Eliava Foundation, Tbilisi, Georgia

    Naomi Hoyle & Fikria Zhvaniya

  7. Eliava BioPreparations, Tbilisi, Georgia

    Zemphira Alavidze

  8. Phagebiotics Research Foundation, Olympia, WA, USA

    Elizabeth Kutter

  9. Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA

    Lasha Gogokhia

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  1. Ryszard Międzybrodzki
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  2. Naomi Hoyle
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  3. Fikria Zhvaniya
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  4. Marzanna Łusiak-Szelachowska
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  5. Beata Weber-Dąbrowska
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  6. Małgorzata Łobocka
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  7. Jan Borysowski
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  8. Zemphira Alavidze
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  9. Elizabeth Kutter
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  10. Andrzej Górski
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  11. Lasha Gogokhia
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Corresponding author

Correspondence to Lasha Gogokhia .

Editor information

Editors and Affiliations

  1. Evolution Biotechnologies , Milton Keynes, United Kingdom

    David R. Harper

  2. Dept. of Microbiology, The Ohio State University Dept. of Microbiology, Mansfield, Ohio, USA

    Stephen T. Abedon

  3. GeneWEAVE Biosciences, Roche Molecular Systems GeneWEAVE Biosciences, Los Gatos, Arkansas, USA

    Benjamin H. Burrowes

  4. Evolution Biotechnologies , Milton Keynes, United Kingdom

    Malcolm L. McConville

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Międzybrodzki, R. et al. (2018). Current Updates from the Long-Standing Phage Research Centers in Georgia, Poland, and Russia. In: Harper, D., Abedon, S., Burrowes, B., McConville, M. (eds) Bacteriophages. Springer, Cham. https://doi.org/10.1007/978-3-319-40598-8_31-1

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  • DOI: https://doi.org/10.1007/978-3-319-40598-8_31-1

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  • Print ISBN: 978-3-319-40598-8

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