Abstract
In the United States, colorectal cancer is the third most commonly diagnosed cancer in both men and women, as well as the third leading cause of cancer deaths (Colorectal cancer facts & figures 2014–2016, 2014 [2]). Worldwide, colorectal cancer is the fourth leading cause of death and causes almost 700,000 deaths each year (Cancer: fact sheet No. 297, 2015 [55]). This chapter discusses the clinical and pathologic features of the spectrum of epithelial, hematolymphoid, and mesenchymal malignant tumors of the colon, rectum, appendix, and anus.
Kaitlin E. Sundling, MD, PhD and Ranran Zhang, MD, PhD have contributed equally.
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References
Adsay NV, Klimstra DS (2014) Neuroendocrine tumors of the gastrointestinal and pancreatobiliary tracts. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
American Cancer Society (2014) Colorectal cancer facts & figures 2014–2016. http://www.cancer.org/acs/groups/content/documents/document/acspc-042280.pdf
American College of Surgeons (2015) Cancer programs practice profile reports (CP3R), rapid quality reporting system (RQRS): colon measure specifications. https://www.facs.org/~/media/files/quality%20programs/cancer/ncdb/measure%20specs%20colon_03312015.ashx
Aoki K, Taketo MM (2007) Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci 120(19):3327–3335
Brand R, Nielsen M, Lynch H, Infante E (2012) GeneReviews. MUTYH-associated polyposis. http://www.ncbi.nlm.nih.gov/books/NBK107219/
Bujanda L, Cosme A, Gil I, Arenas-Mirave JI (2010) Malignant colorectal polyps. World J Gastroenterol 16(25):3103–3111
Caplin M, Sundin A, Nillson O et al (2012) ENETS consensus guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology 95:88–97
Centers for Disease Control and Prevention (2014) What are the risk factors for colorectal cancer? http://www.cdc.gov/cancer/colorectal/basic_info/risk_factors.htm
Dawson IM, Cornes JS, Morson BC (1961) Primary malignant lymphoid tumours of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis. Br J Surg 49:80–89
De Paepe P, De Wolf-Peeters C (2007) Diffuse large B-cell lymphoma: a heterogeneous group of non-Hodgkin lymphomas comprising several distinct clinicopathological entities. Leukemia 21:37–43
Dionigi G, Annoni M, Rovera F et al (2007) Primary colorectal lymphomas: review of the literature. Surg Oncol 16:S169–S171
Downs-Kelly E, Rubin BP, Goldblum JR (2014) Mesenchymal tumors of the gastrointestinal tract. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
Farid M, Lee MJ, Chew MH et al (2013) Localized gastrointestinal stromal tumor of the rectum: An uncommon primary site with prominent disease and treatment-related morbidities. Mol Clin Oncol. 1:190–194
Ferry JA (2014) Hematolymphoid tumors of the gastrointestinal tract, hepatobiliary tract, and pancreas. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
Fox PA (2006) Human papillomavirus and anal intraepithelial neoplasia. Curr Opin Infect Dis. 19:62–66
Francis JM, Kiezun A, Ramos AH et al (2013) Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet 45:1483–1486
Geissmann F, Ruskoné-Fourmestraux A, Hermine O et al (1998) Homing receptor alpha4beta7 integrin expression predicts digestive tract involvement in mantle cell lymphoma. Am J Pathol 153:1701–1705
Goldstein NS (2006) Serrated pathway and APC (Conventional)-type colorectal polyps—Molecular-morphologic correlations, genetic pathways, and implications for classification. Am J Clin Pathol 125(1):146–153
Green B, Raman S (2015) Colorectal lymphoma. Semin Colon Rectal Surg 26:64–67
Hinoi T, Tani M, Lucas PC et al (2001) Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol 159:2239–2248
Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds) (2015). SEER Cancer Statistics Review, 1975–2013, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/, based on November 2015 SEER data submission, posted to the SEER web site, April 2016
Kanehira K, Braylan RC, Lauwers GY (2001) Early phase of intestinal mantle cell lymphoma: a report of two cases associated with advanced colonic adenocarcinoma. Mod Pathol 14:811–817
Kang H, O’Connell JB, Maggard MA, Sack J, Ko CY (2005) A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum 48(6):1161–1168
Klimstra DS, Modlin IR, Coppola D et al (2010) The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas 39:707–712
Kodama T, Ohshima K, Nomura K et al (2005) Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. Histopathology 47:467–478
Koura AN, Giacco GG, Curley SA et al (1997) Carcinoid tumors of the rectum: effect of size, histopathology, and surgical treatment on metastasis free survival. Cancer 79:1294–1298
Kukar M, Kapil A, Papenfuss W et al (2015) Gastrointestinal stromal tumors (GISTs) at uncommon locations: a large population based analysis. J Surg Oncol 111:696–701
Miettinen M, Lasota J (2006) Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 130:1466–1478
Miettinen M, Sarlomo-Rikala M, Sobin LH et al (2005) Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases. Am J Surg Pathol 24:1339–1352
Misdraji J (2014) Epithelial neoplasm of the appendix. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
Modlin IM, Lye KD, Kidd M (2003) A 5-decade analysis of 13,715 carcinoid tumors. Cancer 97:934–959
Modlin IM, Sandor A (1997) An analysis of 8305 cases of carcinoid tumors. Cancer 79:813–829
National Cancer Institute (2015) Genetics of colorectal cancer. http://www.cancer.gov/types/colorectal/hp/colorectal-genetics-pdq
Pelosi G, Fraggetta F, Sonzogni A et al (2000) CD99 immunoreactivity in gastrointestinal and pulmonary neuroendocrine tumours. Virchows Arch 437:270–274
Plesec TP, Owens SR (2014) Inflammatory and neoplastic disorders of the anal canal. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
Quayle FJ, Lowney JK (2006) Colorectal lymphoma. Clin Colon Rectal Surg 19:49–53
Redston M, Driman DK (2014) Epithelial neoplasms of the large intestine. In: Odze RD, Goldblum JR (eds) Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract and Pancreas, 3rd edn. Saunders, Philadelphia
Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW et al (2012) Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 107(9):1315–1330
Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM et al (2003) Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 349(3):247–257
Rindi G, Arnold R, Bosman FT et al (2010) Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Hruban RH et al (eds) WHO classification of tumours of the digestive system, 4th edn. IARC, Lyon
Romaguera J, Hagemeister FB (2005) Lymphoma of the colon. Curr Opin Gastroenterol 21:80–84
Rubin EM, Raptopoulos VD (2005) Images in clinical medicine. The virtual apple core of a colonic carcinoma. N Engl J Med 352(26):2733
Ruoff C, Hanna L, Zhi W et al (2011) Cancers Appendix Rev Literatures 2011:728579
Rutter M, Saunders B, Wilkinson K et al (2004) Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 126:451–459
Sangoi AR, Ohgami RS, Pai RK et al (2011) PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol 24:412–424
Schreibman IR, Baker M, Amos C, McGarrity TJ (2005) The hamartomatous polyposis syndromes: a clinical and molecular review. Am J Gastroenterol 100(2):476–490
Shepherd NA, Baxter KJ, Love SB (1997) The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology 112(4):1096–1102
Snover DC (2011) Update on the serrated pathway to colorectal carcinoma. Hum Pathol 42(1):1–10
Sobhani I, Amiot A, Le Baleur Y, Levy M, Auriault M-L, Jeanne Tran Van N et al (2013) Microbial dysbiosis and colon carcinogenesis: could colon cancer be considered a bacteria-related disease? Ther Adv Gastroenterol 6(3):215–229
Thirunavukarasu P, Sathaiah M, Singla S et al (2010) Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol 37:901–907
Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J et al (2004) Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268
Welton ML, Lambert R, Bosman FT (2010) Tumours of the anal canal. In: Bosman FT, Carneiro F, Hruban RH et al (eds) WHO classification of tumours of the digestive system, 4th edn. IARC, Lyon
Wick MR, Vitsky JL, Ritter JH et al (2005) Sporadic medullary carcinoma of the colon: a clinicopathologic comparison with nonhereditary poorly differentiated enteric-type adenocarcinoma and neuroendocrine colorectal carcinoma. Am J Clin Pathol 123:56–65
Winn B, Tavares R, Fanion J et al (2009) Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation. Hum Pathol 40:398–404
World Health Organization (2015) Cancer: fact sheet No. 297. http://www.who.int/mediacentre/factsheets/fs297/en/
Yao JC, Hassan M, Phan A et al (2008) One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26:3063
Zhang L, Smyrk TC, Oliveira AM et al (2009) KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. Am J Surg Pathol 33:1562
Zighelboim J, Larson MV (1994) Primary colonic lymphoma. Clinical presentation, histopathologic features, and outcome with combination chemotherapy. J Clin Gastroenterol 18:291–297
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Sundling, K.E., Zhang, R., Matkowskyj, K.A. (2016). Pathologic Features of Primary Colon, Rectal, and Anal Malignancies. In: Bentrem, D., Benson, A. (eds) Gastrointestinal Malignancies. Cancer Treatment and Research. Springer, Cham. https://doi.org/10.1007/978-3-319-34244-3_15
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