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Contemporary Heart Transplantation pp 1–16Cite as

Malignancy After Transplant

  • Living reference work entry
  • First Online:

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Part of the book series: Organ and Tissue Transplantation ((OTT))

Abstract

An underappreciated but important complication of heart transplantation is the development of post-transplant malignancy. With continued improvements of heart transplant recipient survival, the prominence of these malignancies has been increasingly recognized, leading to more investigation regarding their pathophysiology and impacts on treatment and prognosis. As a result, there is a better understanding of the unique malignancy risks associated with transplant recipients and the effects on clinical outcomes. Although there are a variety of risk factors for malignancy that overlap with non-transplant recipients, immunosuppression plays a unique and significant role in malignancy pathogenesis. Malignancy type varies widely, from virus-associated malignancies such as post-transplant lymphoproliferative disorder to dermatologic malignancies such as non-melanomatous skin cancer. Strategies for prevention, screening, and treatment of these malignancies are continually evolving. This chapter reviews the epidemiology and types of malignancies post-transplant and the role immunosuppression regimens may play toward the development and in treatment of these malignancies.

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Author information

Authors and Affiliations

  1. Division of Cardiology, UT Southwestern Medical Center, Dallas, TX, USA

    Daniel Cheeran

  2. University of Texas Southwestern Medical Center, Dallas, TX, USA

    Robert M. Morlend

  3. University Hospital Heart & Lung Clinic, UT Southwestern Medical Center, Dallas, TX, USA

    Justin L. Grodin

Authors
  1. Daniel Cheeran
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  2. Robert M. Morlend
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  3. Justin L. Grodin
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Corresponding author

Correspondence to Daniel Cheeran .

Editor information

Editors and Affiliations

  1. Cardiac, Vascular and Thoracic Surgery, Inova Fairfax Hospital, Falls Church, VA, VA, USA

    Linda Bogar

  2. Heart Failure/Transplant Cardiologist, The Cleveland Clinic Foundation, Cleveland, OH, OH, USA

    Maria Mountis

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Cheeran, D., Morlend, R.M., Grodin, J.L. (2019). Malignancy After Transplant. In: Bogar, L., Mountis, M. (eds) Contemporary Heart Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-33280-2_38-1

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  • DOI: https://doi.org/10.1007/978-3-319-33280-2_38-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33280-2

  • Online ISBN: 978-3-319-33280-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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