Abstract
Relapsing polychondritis (RP) is a systemic disease of unknown etiology, associated with the formation of antibodies to type II collagen, the type of collagen predominating in the cartilage. This results in inflammation of the cartilage of the ears, nose, tracheobronchial tree, and joints (Foidart et al., New Engl J Med., 1978;299:1203–7). Involvement of the inner ear and heart may be explained by evidence suggesting that type II collagen exists in those tissues (Rahkonen et al., Histochem Cell Biol. 2003;120:103–10; Dreiling et al., Hear Res. 2002;166:181–91). Murine models suggest that tissue-specific antibody and complement activation are both necessary for expression of the disease (Hansson et al. Am J Pathol. 2004;164:959–966).
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References
Jaksch-Wartenhorst R. Polychondropathia. Wien Arch Int Med. 1923;6:93–100.
Pearson CM, Kline HM, Newcomer VD. Relapsing polychondritis. New Engl J Med. 1960;263:51–8.
Foidart JM, Abe S, Martin GR, et al. Antibodies to type II collagen in relapsing polychondritis. New Engl J Med. 1978;299:1203–7.
Rahkonen O, Savontaus M, Abdelwahid E, Vuorio E, Jokinen E. Expression patterns of cartilage collagens and Sox9 during mouse heart development. Histochem Cell Biol. 2003;120:103–10.
Dreiling FJ, Henson MM, Henson Jr OW. Immunolabeling type II collagen in the basilar membrane: a pre-embedding approach. Hear Res. 2002;166:181–91.
Hansson AS, Johannesson M, Svensson L, Nandakumar KS, Heinegard D, Holmdahl R. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Am J Pathol. 2004;164:959–66.
Terato K, Shimozuru Y, Katayama K, et al. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthritis Rheum. 1990;33:1493–500.
Yoo TJ, Lee MK, Min YS, et al. Epitope specificity and T cell receptor usage in type II collagen induced autoimmune disease. Cell Immunol. 1994;157:249–62.
Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014;13:90–5.
Lang B, Rothenfusser A, Lanchbury JS, et al. Susceptibility to relapsing polychondritis is associated with HLA-DR4. Arthritis Rheum. 1993;36:660–4.
Cañas CA, Bonilla Abadía F. Local cartilage trauma as a pathogenic factor in autoimmunity (one hypothesis based on patients with relapsing polychondritis triggered by cartilage trauma). Autoimmune Dis. 2012;2012:453698. doi:10.1155/2012/453698. Epub 2011 Oct 27.
O’Hanlan M, McAdam LP, Bluestone R, Pearson CM. The arthropathy of relapsing polychondritis. Arthritis Rheum. 1976;19:191–4.
Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med. 1998;129:114–22.
McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine. 1976;55:193–215.
Michet CJ, McKenna CH, Luthra HS, O’Fallon WM. Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med. 1986;104:74–8.
Frances C, El Rassi R, Laporte JL, Rybojad M, Papo T, Piette JC. Dermatologic manifestations of relapsing polychondritis. Medicine. 2001;80:173–9.
Bhamra K, Weerasinghe R, Steuer A. Epididymo-orchitis as a presenting feature of relapsing polychondritis: a case report. Case Rep Rheumatol. 2011;2011:726038. doi:10.1155/2011/726038. Epub 2012 Jan 4.
Fujimoto N, Tajima S, Ishibashi A, Ura-Ishikou A, Manaka I. Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in a patient with relapsing polychondritis. Br J Dermatol. 1998;139:930–1.
Bernard P, Bedane C, Delrous JL, Catanzano G, Bonnetblanc JM. Erythema elevatum diutinum in a patient with relapsing polychondritis. J Am Acad Dermatol. 1992;26:312–5.
Herrera I, Concha R, Molina EG, Schiff ER, Altman RD. Relapsing polychondritis, chronic hepatitis C infection, and mixed cryoglobulinemia. Semin Arthritis Rheum. 2004;33:388–403.
Dolev JC, Maurer TA, Reddy SG, Ramirez LE, Berger T. Relapsing polychondritis in HIV-infected patients: a report of two cases. J Am Acad Dermatol. 2004;51:1023–5.
Feinerman LK, Johnson WC, Weiner J, Graham JH. Relapsing polychondritis: a histopathologic and histochemical study. Dermatologica. 1970;140:369–77.
Kent PD, Michet CJ, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol. 2003;16:56–61.
Valenzuela R, Cooperrider PA, Gogate P, Deodhar SD, Bergfeld WF. Relapsing polychondritis: immunomicroscopic findings in cartilage of ear biopsy specimens. Hum Pathol. 1980;11:19–22.
Lekpa FK, Kraus VB, Chevalier X. Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum. 2012;41:712–9.
Navarro MJ, Higgins GC, Lohr KM, Myers LK. Amelioration of relapsing polychondritis in a child treated with oral collagen. Am J Med Sci. 2002;324:101–3.
Sidhu M, Griffiths MM, Bradley DS. Vaccination with collagen-pulsed dendritic cells prevents the onset and reduces the disease severity in the mouse model of spontaneous polychondritis. Clin Exp Immunol. 2009;157:350–8.
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Somach, S.C. (2016). Relapsing Polychondritis. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_39
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DOI: https://doi.org/10.1007/978-3-319-31566-9_39
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