Skip to main content
SpringerLink
Log in

Staphylococcal Toxin-Mediated Scalded Skin and Toxic Shock Syndromes

  • Chapter
  • First Online:
Deadly Dermatologic Diseases

  • 900 Accesses

Abstract

Credit for the first clinical description of SS belongs to Ritter von Rittershain, who in 1878 described 297 cases of a generalized exfoliative exanthem in neonates. An association with staphylococcus and subsequently the mechanism of phage-mediated toxin elaboration would be discovered in the 1940s and 1950s. The toxin-mediated staphylococcal syndromes of staphylococcal scalded skin syndrome (SSSS) and toxic shock syndrome (TS) constitute important dermatologic entities capable of producing significant morbidity and mortality. Distinctive clinical and pathologic attributes usually permit their early recognition, allowing for prompt institution of potentially lifesaving therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. von Rittershain RG. Dermatitis jungerer sauglinge. Zentralzeitung fur Kinderheilkunde. 1878;2:3.

    Google Scholar 

  2. Melish M. Staphylococci, streptococci and the skin: review of impetigo and the staphylococcal scalded skin syndrome. Semin Dermatol. 1992;1:101.

    Google Scholar 

  3. Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nat Med. 2000;6(11):1275–7.

    Article  CAS  PubMed  Google Scholar 

  4. Richard M, Mathieu-Serra A. Staphylococcal scalded skin syndrome in a homosexual adult. J Am Acad Dermatol. 1986;15(2 Pt 2):385–9.

    Article  CAS  PubMed  Google Scholar 

  5. Cribier B, Piemont Y, Grosshans E. Staphylococcal scalded skin syndrome in adults. A clinical review illustrated with a new case. J Am Acad Dermatol. 1994;30(2 Pt 2):319–24.

    Article  CAS  PubMed  Google Scholar 

  6. Lyell A. The staphylococcal scalded skin syndrome in historical perspective: emergence of dermopathic strains of Staphylococcus aureus and discovery of the epidermolytic toxin. A review of events up to 1970. J Am Acad Dermatol. 1983;9(2):285–94.

    Article  CAS  PubMed  Google Scholar 

  7. Handler MZ, Schwartz RA. Staphylococcal scalded skin syndrome: diagnosis and management in children and adults. J Eur Acad Dermatol Venereol. 2014;28(11):1418–23.

    Article  CAS  PubMed  Google Scholar 

  8. Institute of Medicine Report on Toxic Shock Syndrome. Ann Intern Med. 1982;97(1):133–3.

    Google Scholar 

  9. Tofte RW, Williams DN. Toxic shock syndrome: clinical and laboratory features in 15 patients. Ann Intern Med. 1981;94(2):149–56.

    Article  CAS  PubMed  Google Scholar 

  10. Huntley AC, Tanabe JL. Toxic shock syndrome as a complication of dermatologic surgery. J Am Acad Dermatol. 1987;16(1 Pt 2):227–9.

    Article  CAS  PubMed  Google Scholar 

  11. Manders SM. Toxin-mediated streptococcal and staphylococcal disease. J Am Acad Dermatol. 1998;39(3):383–98; quiz 399–400.

    Article  CAS  PubMed  Google Scholar 

  12. Elias PM, Fritsch P, Epstein EH. Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments. Arch Dermatol. 1977;113(2):207–19.

    Article  CAS  PubMed  Google Scholar 

  13. Cone LA, Woodard DR, Byrd RG, Schulz Z. J Infect DIs 1992 165: 638–43.

    Google Scholar 

  14. Hurwitz RM, Ackerman AB. Cutaneous pathology of the toxic shock syndrome. Am J Dermatopathol. 1985;7(6):563–78.

    Article  CAS  PubMed  Google Scholar 

  15. Braunstein I, Wanat KA, Abuabara K, McGowan KL, Yan AC, Treat JR. Antibiotic sensitivity and resistance patterns in pediatric staphylococcal scalded skin syndrome. Pediatr Dermatol. 2014;31(3):305–8.

    Article  PubMed  Google Scholar 

  16. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011;52(3):285–92.

    Article  PubMed  Google Scholar 

  17. Li MY, Hua Y, Wei GH, Qiu L. Staphylococcal scalded skin syndrome in neonates: an 8-year retrospective study in a single institution. Pediatr Dermatol. 2014;31(1):43–7.

    Article  PubMed  Google Scholar 

  18. Schlievert PM. Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses. J Allergy Clin Immunol. 2001;108(4 Suppl):S107–10.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Director of Dermatopathology, Dermatology Specialists of Florida, Panama City, FL, USA

    Michael B. Morgan MD

  2. Staff Dermatopathologist, Advanced Dermatology and Cosmetic Surgery, Clermont, FL, USA

    Michael B. Morgan MD

  3. Professor of Dermatology, Michigan State College of Medicine, East Lancing, USA

    Michael B. Morgan MD

Authors
  1. Alexander Herbst MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael B. Morgan MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael B. Morgan MD .

Editor information

Editors and Affiliations

  1. Assistant Professor Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    David R. Crowe

  2. Dermpath Diagnostics, Tampa, Florida, USA

    Michael Morgan

  3. MetroHealth Medical Center, Cleveland, Ohio, USA

    Stephen Somach

  4. Washington, District of Columbia, USA

    Kara Trapp

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Herbst, A., Morgan, M.B. (2016). Staphylococcal Toxin-Mediated Scalded Skin and Toxic Shock Syndromes. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31566-9_33

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31564-5

  • Online ISBN: 978-3-319-31566-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation