Skip to main content

Eruptive Xanthoma

  • Chapter
  • First Online:
Deadly Dermatologic Diseases

Abstract

Eruptive xanthoma (EX) is a distinct cutaneous entity that most commonly manifests in the skin following a severe systemic dyslipidemia. Although the dermatologic manifestations are not in themselves serious, their presence may be the harbinger of serious visceral disease. EX is an uncommon disease with a near equal gender incidence, principally seen in two age groups with different predisposing factors. Elevated serum triglyceride levels and/or very low-density lipoproteins (VLDL) appear to be a common underlying feature in both age groups. Primary causes occur more often among children and young adults. They include genetic disturbances in lipid metabolism like lipoprotein lipase deficiency and types I and V hyperlipoproteinemias. Secondary causes are observed more in older adults, such as acute ethanol ingestion and endocrinologic disturbances including hypothyroidism and diabetes mellitus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Parker F. Xanthomas and hyperlipidemias. J Am Acad Dermatol. 1985;13(1):1–30.

    Article  CAS  PubMed  Google Scholar 

  2. Ranjan N. Management of hyperlipidemias: an update. Indian J Dermatol Venereol Leprol. 2009;75(5):452–62.

    Article  PubMed  Google Scholar 

  3. Leaf DA. Chylomicronemia and the chylomicronemia syndrome: a practical approach to management. Am J Med. 2008;121(1):10–2.

    Article  PubMed  Google Scholar 

  4. Archer CB, MacDonald DM. Eruptive xanthomata in type V hyperlipoproteinaemia associated with diabetes mellitus. Clin Exp Dermatol. 1984;9(3):312–6.

    Article  CAS  PubMed  Google Scholar 

  5. Brunzell JD, Bierman EL. Chylomicronemia syndrome. Interaction of genetic and acquired hypertriglyceridemia. Med Clin North Am. 1982;66(2):455–68.

    Article  CAS  PubMed  Google Scholar 

  6. Vermeer BJ, et al. Xanthomatosis and other clinical findings in patients with elevated levels of very low density lipoproteins. Br J Dermatol. 1979;100(6):657–66.

    Article  CAS  PubMed  Google Scholar 

  7. Burnside NJ, et al. Type III hyperlipoproteinemia with xanthomas and multiple myeloma. J Am Acad Dermatol. 2005;53(5 Suppl 1):S281–4.

    Article  PubMed  Google Scholar 

  8. Barr RJ, Fujita WH, Graham JH. Eruptive xanthomas associated with intravenous miconazole therapy. Arch Dermatol. 1978;114(10):1544–5.

    Article  CAS  PubMed  Google Scholar 

  9. Dicken CH, Connolly SM. Eruptive xanthomas associated with isotretinoin (13-cis-retinoic acid). Arch Dermatol. 1980;116(8):951–2.

    Article  CAS  PubMed  Google Scholar 

  10. Chang HY, et al. Eruptive xanthomas associated with olanzapine use. Arch Dermatol. 2003;139(8):1045–8.

    Article  PubMed  Google Scholar 

  11. Yuan G, Al-Shali KZ, Hegele RA. Hypertriglyceridemia: its etiology, effects and treatment. CMAJ. 2007;176(8):1113–20.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Jaber PW, et al. Eruptive xanthomas during pregnancy. J Am Acad Dermatol. 1992;27(2 Pt 2):300–2.

    Article  CAS  PubMed  Google Scholar 

  13. Maher-Wiese VL, Marmer EL, Grant-Kels JM. Xanthomas and the inherited hyperlipoproteinemias in children and adolescents. Pediatr Dermatol. 1990;7(3):166–73.

    Article  CAS  PubMed  Google Scholar 

  14. Sandhu S, et al. Incidence of pancreatitis, secondary causes, and treatment of patients referred to a specialty lipid clinic with severe hypertriglyceridemia: a retrospective cohort study. Lipids Health Dis. 2011;10:157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Loeckermann S, Braun-Falco M. Eruptive xanthomas in association with metabolic syndrome. Clin Exp Dermatol. 2010;35(5):565–6.

    Article  CAS  PubMed  Google Scholar 

  16. Li CN, Lee WR, Tseng JT. Dystrophic xanthomatization as a type of Wolf’s isotopic response: eruptive xanthomata at a herpes zoster site. J Am Acad Dermatol. 2013;68(2):e53–5.

    Article  PubMed  Google Scholar 

  17. Kruth HS. Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles. Curr Opin Lipidol. 2011;22(5):386–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell. 2011;145(3):341–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Zahavi A, Snir M, Kella YR. Lipemia retinalis: case report and review of the literature. J AAPOS. 2013;17(1):110–1.

    Article  PubMed  Google Scholar 

  20. Cooper PH. Eruptive xanthoma: a microscopic simulant of granuloma annulare. J Cutan Pathol. 1986;13(3):207–15.

    Article  CAS  PubMed  Google Scholar 

  21. Valdivielso P, Ramirez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014;25(8):689–94.

    Article  CAS  PubMed  Google Scholar 

  22. Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med. 2006;354(20):2142–50.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael B. Morgan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Schuering, R., Morgan, M.B. (2016). Eruptive Xanthoma. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31566-9_25

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31564-5

  • Online ISBN: 978-3-319-31566-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics