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Hemimegalencephaly

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Textbook of Pediatric Neurosurgery

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Abstract

Hemimegalencephaly (HME) is a rare, congenital disorder that raises a great interest in the scientific community because of its particular features, namely, to be mainly confined to one cerebral hemisphere; to combine anomalies in neuronal migration, differentiation, and proliferation; and to present medical resistant seizures since the first days of life. The term “hemimegalencephaly” was coined by Sims in 1835 to describe the case of a woman with the left cerebral hemisphere occupying two thirds of the whole intracranial space (Sims 1835).

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Authors and Affiliations

  1. Pediatric Neurosurgery, A. Gemelli Hospital, Rome, Italy

    Luca Massimi

  2. International Department of Neurosurgery, Neuroscience Institute, Hannover, Germany

    Concezio Di Rocco

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Correspondence to Luca Massimi .

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  1. International Neuroscience Institute, Hannover, Germany

    Concezio Di Rocco

  2. Oakland Medical Center, Oakland, California, USA

    Dachling Pang

  3. University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada

    James T. Rutka

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  1. Department of Neurosurgery, International Neuroscience Institute, Hannover, Germany

    Concezio Di Rocco

  2. Pediatric Neurosurgery, Catholic University Medical School, Rome, Italy

    G. Tamburrini

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Massimi, L., Di Rocco, C. (2018). Hemimegalencephaly. In: Di Rocco, C., Pang, D., Rutka, J. (eds) Textbook of Pediatric Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-31512-6_47-1

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