Abstract
The bony craniovertebral junction (CVJ) can be conceptually divided into two components with respect to the governance of intersegmental movements and functional space for the nervous system. The first component consists mainly of a central pivot made up of the dens and the C2 vertebral body, but the basiocciput, though anatomically part of the foramen magnum, is embryologically and functionally in vertical linearity with the dens and is thus part of the central pillar. The second component consists of two ringed structures surrounding the central pivot, albeit eccentrically. They are the foramen magnum ring, comprising the lateral portion of the basiocciput (clivus), the exocciput including the occipital condyles, and the opisthion; and the atlantal ring, with its anterior and posterior arches and lateral masses. These two superimposing rings transmit the lower brainstem and upper cervical spinal cord, while permitting limited rotatory and flexion-extension motions upon each other and round the dental pivot. Straddling these two rings and anchoring upon them are the stabilizing ligaments between the pivot and the rings: the alar and apical dental ligaments at the upside of the pivot, the transverse atlantal ligament (TAL) across the main dental shaft, and the arching mantle of the tectorial membrane and cruciate ligament, strapping the clivus to the whole of the dens-axis assembly.
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References
Aoyoma H, Asamoto K (1988) Determination of somite cells: independence of cell differentiation and morphogenesis. Development 104:15–28
Bagnall KM (1992) The migration and distribution of somite cells after labelling with the carbocyanine dye, DiI: the relationship of this distribution to segmentation in the vertebrate body. Anat Embryol 185:317–324
Bagnall KM, Sander EJ (1989) The binding pattern of peanut lectin associated with sclerotome migration and the formation of the vertebral axis in the chick embryo. Anat Embryol 180:505–513
Bellairs R (1980) The segmentation of somites in the chick embryo. Boll Zool 47:245–252
Burwood RJ (1970) The cranio-cervical junction. Anatomy, University of Bristol, Bristol
Cattell JS, Filtzer DL (1965) Pseudosubluxation and other normal variations in the cervical spine in children. J Bone Joint Surg Am 47A:1295–1309
Cave AJE (1938) The morphological constitution of the odontoid process. J Anat 72:621
Chevrel JP (1965) Occipitalization of the atlas. Arch Orthop Trauma Surg 13:104–108
Chigira M, Kaneko K, Mashio D, Watanabe H (1994) Congenital hypoplasia of the arch of the atlas with abnormal segmentation of the cervical spine. Arch Orthop Trauma Surg 113:110–112
Christ B, Wilting J (1992) From somites to vertebral column. Ann Anat 174:23–32
Christ B, Jacob HJ, Jacob M (1978) On the formation of the myotomes in avian embryos. An experimental and scanning electron microscope study. Experientia 34:514–516
Christ B, Jacob HJ, Siefert R (1988) Über die Entwicklung der Zervikookzipitalen Übergangsregion. In: Hohmann D, Kügelgen B, Liebig K (eds) Neuroorthopädie, vol 4. Springer, Berlin/Heidelberg, pp 13–22
Condie B, Capecchi MR (1993) Mice homozygous for a targeted disruption of Hox d-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and axis. Development 119:579–595
Couly GF, Coltey PM, Le Douarin NM (1993) The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development 117:409–429
Crockard H, Stevens M (1995) Craniovertebral junction anomalies in inherited disorder: part of the syndrome or caused by the disorder? Eur J Pediatr 154:504–512
Dalgleish AE (1985) A study of the development of thoracic vertebrae in the mouse assisted by autoradiography. Acta Anat 122:91–98
David KM, Crockard A (2005) Congenital malformations of the base of the skull, atlas and dens. In: Benzel EC (ed) The cervical spine, 4th edn. Lippincott Williams and Wilkins, Philadelphia, pp 415–426
David KM, Thorogood P, Stevens JM, Crockard HA (1997) The one bone spine: a failure of notochord/sclerotome signaling? Clin Dysmorphol 6:303–314
David KM, Thorogood PV, Stevens JM, Crockard A (1999) The dysmorphic cervical spine in Klippel-Feil syndrome: interpretations from developmental biology. Neurosurg Focus 6(6):Article 1
Davis GK, Patel NH (1999) The origin and evolution of segmentation. Trends Cell Biol 9:M68–M72
Davis GK, Jaramillo CA, Patel NH (2001) Pax group III genes and the evolution of insect pair-rule patterning. Development 128:3445–3458
Devi BI, Shenoy SN, Panigrahi MK, Chandramouli BA, Das BS, Jayakumar PN (1997) Anomaly of arch of atlas – a rare cause of symptomatic canal stenosis in children. Pediatr Neurosurg 26:214–218
Dietrich S, Gruss P (1995) Undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures. Dev Biol 167:529–548
Dietrich S, Kessel M (1997) The vertebral column. In: Thorogood P (ed) Embryos, genes and birth defects. Wiley, Chichester, pp 281–302
Dietrich S, Schubert FR, Gruss P (1993) Altered Pax gene expression in notochord mutants of the mouse: the notochord is required for the dorsoventral patterning of the somite. Mech Dev 44:189–207
Dubrulle J, McGrew MJ, Pourquié O (2001) FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 106:219–232
Forsberg H, Crozet F, Brown NA (1998) Waves of mouse lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation. Curr Biol 8:1027–1030
Geipel P (1955) Zur Kenntnis der Spaltbildungen des Atlas und Epistropheus, Teil IV. Zbl Path 94:19
George AW (1919) A method for more accurate study of injuries to the atlas and axis. N Engl J Med Surg 181:395–398
Gholve PA, Hosalker HS, Ricchetti ET, Pollock AN, Dormans JP, Drummond DS (2007) Occipitalization of the atlas in children, morphologic classification, associations, and clinical relevance. J Bone Joint Surg Am 89:571–578
Giacomini C (1886) Sull’ esistenza dell’ “osodontoideum: nell” uomo. G Accad Med Torino 49:24–28
Grabb PA, Mapstone TB, Oakes WJ (1999) Ventral brainstem compression in pediatric and young adult patients with Chiari I malformations. Neurosurgery 44:520–528
Haack H, Kessel M (1994) Homeobox genes and skeletal patterning. In: Hall BK (ed) Bone, vol 9. CRC Press, Boca Raton, pp 119–144
Hawkins RJ, Fielding JW, Thompson WJ (1976) Os odontoideum: congenital or acquired? J Bone Joint Surg Am 38:413–414
Hensinger RN (1986) Osseous anomalies of the craniovertebral junction. Spine 11:323–333
Hensinger RN, Fielding JW, Hawkins RJ (1978) Congenital anomalies of the odontoid process. Orthop Clin N Am 9:901–912
Huang R, Zhi Q, Ordahl CP, Christ B (1997) The fate of the first avian somite. Anat Embryol (Berl) 195:435–449
Jacob M, Christ B, Jacob HJ (1975) Über die regionale Determination des paraxialen Mesoderms junger Hühnerembryonen. Verh Anat Ges (Ger) 69:263–269
Jenkins JFA (1969) The evolution and development of the dens of the mammalian axis. Anat Rec 164:173–184
Jones FS, Georges C, Guss P, Edelman GM (1991a) Activation of the cytotactin promoter by the homeobox-containing gene Evx-1. Proc Natl Acad Sci U S A 89:2091
Jones FS, Prediger EA, Dennis BA, DeRobertis EM, Edelman GM (1991b) Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox 2.5 and 2.4. Proc Natl Acad Sci U S A 89:2091
Kessel M (1992) Respecification of vertebral identities by retinoic acid. Development 115:487–501
Kessel M, Gruss P (1991) Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67:1–20
Keynes RJ, Stern CD (1988) Mechanisms of vertebrate segmentation. Development 103:413–429
Kieny M, Mauger A, Sengel P (1972) Early regionalization of the somitic mesoderm as studied by the development of the axial skeleton of the chick embryo. Dev Biol 28:42–161
Kirlew KA, Hathout GM, Reiter SD, Gold RH (1993) Os odontoideum in identical twins: perspective on etiology. Skelet Radiol 22:525–527
Koseki H, Wallin J, Wilting J et al (1993) A role for Pax-1 as mediator of notochordal signals during the dorsoventral specification of vertebrae. Development 119:649–660
Kotil D, Kalayci M (2005) Ventral cervicomedullary junction compression secondary to condylus occipitalis (median occipital condyle), a rare entity. J Spinal Disord Tech 18(4):382–385
Le Double AF (1903/1912) Traité des variations des os du crane de l’homme et de leur signification au point de vue de l’Anthropologie zoologique. Vigot Frères, Paris
Logan WW, Stuard ID (1973) Absence of posterior arch of the atlas. Am J Roentgenol 118:431–434
Lufkin T, Mark M, Hart CP, Dollé P, LeMeur M, Chambon P (1992) Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature 359:835–841
Macalister A (1893) Notes on the development and variations of the atlas. J Anat Physiol 27:519–542
Markuske H (1978) Untersuchungen zur Static und Dynamik der kindlichen Halswirbelsäule: Der Aussagewert seitlicher Röntgenaufnahmen. In: Die Wirbelsäule in Forschung und Praxis, vol 50. Hippokrates, Stuttgart
McGrew MJ, Dale JK, Fraboulet S, Pourquié O (1998) The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos. Curr Biol 8:979–982
McRae DL (1953) Bony abnormalities in the region of the foramen magnum; correlation of the anatomic and neurologic findings. Acta Radiol 40:335–354
McRae DL (1960) The significance of abnormalities of the cervical spine. Am J Roentgenol 84:3–25
McRae DL, Barnum AS (1953) Occipitalization of the atlas. Am J Roentgenol Radium Therapy, Nucl Med 70:23–46
Menezes AH (1996) Congenital and acquired abnormalities of the craniovertebral junction. In: Youmans JR (ed) Neurological surgery, 4th edn. WB Saunders, Philadelphia, pp 1035–1089
Menezes AH (1998) Embryology, development, and classification of disorders of the craniovertebral junction. In: Dickman CA, Sonntag VKH, Spetzler RF (eds) Surgery of the craniovertebral junction. Thieme, New York, pp 3–12
Menezes AH, Fenoy KA (2009) Remnants of occipital vertebrae: proatlas segmentation abnormalities. Neurosurgery 64:945–953
Menezes AH, Ryken TC (1992) Craniovertebral abnormalities in Down’s syndrome. Neurosurgery 18:24–33
Morgan MK, Onofrio BM, Bender CE (1989) Familial os odontoideum. Case report. J Neurosurg 70:636–639
Müller F, O’Rahilly R (1980) The human chondrocranium at the end of the embryonic period, proper, with particular reference to the nervous system. Am J Anat 159:33–58
Müller F, O’Rahilly R (1994) Occipitocervical segmentation in staged human embryos. J Anat 185:251–258
Müller F, O’Rahilly R (2003) Segmentation in staged human embryos: the occipitocervical region revisited. J Anat 203:251–258
Musil L, Goodenough D (1990) Gap junctional intercellular communication and the regulation of connexin expression and function. Curr Opin Cell Biol 2:875
Nishikawa M, Sakamoto H, Hakuba A, Nakanishi N, Inoue Y (1997) Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa. J Neurosurg 86:40–47
Palmeirim I, Henrique D, Ish-Horowicz D, Pourquié O (1997) Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell 91:639–648
Pendergrass EP, Schaeffer JP, Hodes PJ (1956) The head and neck in Roentgen diagnosis, 2nd edn. Charles C. Thomas, Springfield, pp 1529–1530
Pollack I, Pang D, Albright LA, Krieger D (1992a) Outcome following hind brain decompression of symptomatic Chiari malformations in children previously shunted with myelomeningoceles. J Neurosurg 77:881–888
Pollack I, Pang D, Kocoshis S, Putnam P (1992b) Neurogenic dysphagia resulting from Chiari malformations. Neurosurgery 30:709–719
Pourquié O (2003a) Vertebrate somitogenesis: a novel paradigm for animal segmentation? Int J Dev Biol 47:597–603
Pourquié O (2003b) The segmentation clock: converting embryonic time into spatial pattern. Science 301:328–330
Prescher A (1990) The differential diagnosis of isolated ossicles in the region of the dens axis. Gegenbaurs Morphol Jahrb 136:139–154
Prescher A (1997) The craniocervical junction in man, the osseous variations, their significance and differential diagnosis. Ann Anat 179:1–19
Prescher A, Brors D, Adam G (1996) Anatomic and radiologic appearance of several variants of the craniocervical junction. Skull Base Surg 6:83–94
Rao P (2002) Median (third) occipital condyle. Clin Anat 15:148–151
Reiter A (1944) Die Frühentwicklung der menschlichen Wirbelsäule. II. Mitteilung: Die Entwicklung der Occipitalsegmente und der Halswirbelsäule. Z Anat Entwicklungsgesch 113:66–104
Remak R (1855) Untersuchungen über die Entwicklung der Wirbeltiere. G. Reimer, Berlin
Sawada A, Shinya M, Jiang YJ, Kawakami A, Kuroiwa A, Takeda H (2001) Fgf/MAPK signaling is a crucial positional cue in somite boundary formation. Development 128:4873–4880
Schulze P, Buurman R (1980) Absence of the posterior arch of the atlas. Am J Roentgenol 134:178–180
Sensenig EC (1957) The development of the occipital and cervical segments and their associated structures in human embryos. Contrib Embryol 36:152–161
Smith CA, Tuan RS (1994) Human PAX gene expression and development of the vertebral column. Clin Orthop Relat Res 302:241–250
Stapleton P, Weith A, Urbanek P, Kozmik Z, Busslinger M (1993) Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet 3:292
Starck D (1979) Das Skelettsystem. In: Starck D (ed) Vergleichende Anatomie der Wirbeltiere, vol 2. Springer, Berlin/Heidelberg/New York, pp 44–95
Stern CD, Keynes RJ (1987) Interactions between somite cells; the formation and maintenance of segment boundaries in the chick embryo. Development 99:261–272
Stover LJ, Bergan U, Nilsen G, Sjaastad O (1993) Posterior cranial fossa dimensions in the Chiari I malformation: relation to pathogenesis and clinical presentation. Neuroradiology 35:113–118
Tramontano-Guerritore G (1927) Die atlanto-occipital union. Anat Anz 64:173–184
Tubbs RS, Iskandar BJ, Bartolucci AA, Oakes WJ (2004) A critical analysis of the Chiari 1.5 malformation. J Neurosurg 101:179–183
Vega A, Quintana F, Berciano J (1990) Basichondrocranium anomalies in adult Chiari type I malformation: a morphometric study. J Neurol Sci 99:137–145
von Ebner E (1888) Urwirbel und Neugliederung der Wirbelsäule. Sitzungsber Akad Wiss Wein III 97:194–206
von Ludinghausen M, Schindler G, Kageyama I, Pomaroli A (2002) The third occipital condyle, a constituent part of a median occipito-atlanto-odontoid joint: a case report. Surg Radiol Anat 24:71–76
von Torklus D, Gehle W (1969) Neue Perspektiven der Entwicklungsstörungen der oberen Halswirlbelsäule. Z Orthop 105:178
von Torklus D, Gehle W (1972) Anomalies and malformations. In: von Torklus D, Gehle W (eds) The upper cervical spine. Thieme, Stuttgart, pp 14–53
von Torklus D, Gehle W (1975) Die Obere Halswirbelsäule, 2nd edn. Thieme, Stuttgart
Wadia NH (1967) Myelopathy complicating congenital atlantoaxial dislocation (a study of 28 cases). Brain 90:449–472
Wallin J, Mizutani Y, Imai K et al (1993) A new Pax gene, Pax-9, maps to mouse chromosome 12. Mamm Genome 4:354–358
Wallin J, Wilting J, Koseki H, Fritsch R, Christ B, Balling R (1994) The role of Pax-1 in axial skeleton development. Development 120:1109–1121
Wilting J, Ebensperger C, Müller TS, Koseki H, Wallin J, Christ B (1995) Pax-1 in the development of the cervico-occipital transitional zone. Anat Embryol 192:221–227
Wollin DG (1963) The os odontoideum: separate odontoid process. J Bone Joint Surg Am 45:1459–1484
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Pang, D. (2017). Embryology, Classification, and Surgical Management of Bony Malformations of the Craniovertebral Junction. In: Di Rocco, C., Pang, D., Rutka, J. (eds) Textbook of Pediatric Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-31512-6_123-1
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