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Cheilitis Granulomatosa

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 81 Accesses

Synonyms

Cheilitis granulomatosa of Miescher; Orofacial granulomatosis of the lip

Definition

Cheilitis granulomatosa, first described by Miescher in 1945, is together with Melkersson–Rosenthal syndrome subsets of orofacial granulomatosis. Clinically, patients present with a nontender, persistent swelling of one or both lips. The labial swelling may be associated with orofacial swelling affecting the chin, eyelids, cheeks, gingiva, and oral mucosa.

Clinical Features

Incidence

It is estimated that the incidence is 0.08% in the population.

Age

Mostly adults, although it can occur in childhood. In children and adults under 30 years of age, an association with an asymptomatic, non-Crohn’s disease, gastrointestinal inflammatory process, or food allergy has been shown.

Sex

Cheilitis granulomatosa has a female predilection.

Site

Upper and lower lip.

Treatment

First, try to find the underlying cause by thorough clinical examination. Individual lesions have been treated with several different...

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References and Further Reading

  • Critchlow, W. A., & Chang, D. (2014). Cheilitis granulomatosa: A review. Head and Neck Pathology, 8, 209–213.

    Article  PubMed  Google Scholar 

  • El-Hakim, M., & Chauvin, P. (2004). Orofacial granulomatosis presenting as persistent lip swelling: Review of 6 new cases. Journal of Oral and Maxillofacial Surgery, 62, 1114–1117.

    Article  PubMed  Google Scholar 

  • Kaminagakura, E., & Jorge, J., Jr. (2011). Melkersson–Rosenthal syndrome: A histopathologic mystery and dermatologic challenge. Journal of Cutaneous Pathology, 38, 241–245.

    Article  PubMed  Google Scholar 

  • van der Waal, R. I. F., Schulten, E. A. J. M., van der Scheur, M. R., Wauters, I. M. P. M. J., Starink, T. M., & van der Waal, I. (2001). Cheilitis granulomatosa. Journal of the European Academy of Dermatology and Venereology, 15, 519–523.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Jacqueline E. van der Wal

Authors
  1. Jacqueline E. van der Wal
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Corresponding author

Correspondence to Jacqueline E. van der Wal .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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van der Wal, J.E. (2018). Cheilitis Granulomatosa. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_667-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_667-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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