Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Pathology pp 1–2Cite as

Undifferentiated Pleomorphic Sarcoma

  • Living reference work entry
  • First Online:

  • 39 Accesses

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Malignant fibrous histiocytoma

Definition

Undifferentiated pleomorphic sarcoma (UPS) is a malignant mesenchymal tumor with no identifiable line of differentiation. It is a therefore diagnosis of exclusion.

Clinical Features

  • Incidence

    UPS originating in the genitourinary tract is rare, and literature consists mainly of single case reports.

  • Age

    UPS is a tumor of adults, arising mainly in patients between the fifth and the eight decades.

  • Sex

    It occurs predominantly in males.

  • Site

    Genitourinary UPS arises more frequently in the urinary bladder, but few examples have also been reported in the kidney, the prostate, and the spermatic cord (Kunze et al. 1994; Kulmala et al. 1994; Ptochos et al. 1999; Demir et al. 2012).

  • Treatment

    Treatment is surgical, combined in some cases with chemotherapy and radiation.

  • Outcome

    UPS is an aggressive tumor with frequent local and distant relapse and a poor prognosis.

Macroscopy

UPS usually appears as a large multilobulated gray-white, fleshy mass....

This is a preview of subscription content, log in via an institution.

References and Further Reading

  • de Peralta-Venturina, M., Moch, H., Amin, M., Tamboli, P., Hailemariam, S., Mihatsch, M., Javidan, J., Stricker, H., Ro, J. Y., & Amin, M. B. (2001). Sarcomatoid differentiation in renal cell carcinoma: A study of 101 cases. The American Journal of Surgical Pathology, 25, 275–284.

    Article  Google Scholar 

  • Demir, L., Can, A., Dirican, A., Bayoğlu, V., Rezanko, T. A., Akyol, M., Kucukzeybek, Y., Erten, C., & Tarhan, M. O. (2012). Malignant fibrous histiocytoma of the spermatic cord in a patient with polycystic kidney disease; review of the literature. Clinical Genitourinary Cancer, 10, 280–283.

    Article  Google Scholar 

  • Kulmala, R. V., Seppanen, J. H., Vaajalahti, P. J., et al. (1994). Malignant fibrous histiocytoma of the prostate. Case report. Scandinavian Journal of Urology and Nephrology, 28, 429–431.

    Article  CAS  Google Scholar 

  • Kunze, E., Theuring, F., & Kruger, G. (1994). Primary mesenchymal tumors of the urinary bladder. A histological and immunohistochemical study of 30 cases. Pathology, Research and Practice, 190, 311–332.

    Article  CAS  Google Scholar 

  • Ptochos, A., Karydas, G., Iosifidis, N., Tyrothoulakis, E., Papazafiriou, G., & Kehagia-Koutoufari, T. (1999). Primary renal malignant fibrous histiocytoma. A case report and review of the literature. Urologia Internationalis, 63, 261–264.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

Authors
  1. Alessandro Franchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Franchi, A. (2019). Undifferentiated Pleomorphic Sarcoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4964-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4964-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation