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Spermatic Cord Cellular Angiofibroma

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Angiomyofibroblastoma-like tumor

Definition

Rare, circumscribed, slow-growing, benign mesenchymal tumor whose suggested histogenesis is perivascular stem cells.

Clinical Features

  • Incidence

    Very low. About 60 cases of cellular angiofibroma in male genitourinary system are reported in English literature.

  • Age

    It affects adults usually over 50 years of age.

  • Site

    In men, cellular angiofibroma is observed in the inguino-scrotal region (paratesticular, tunica vaginalis, epididymis, and spermatic cord). There are rare reports of perineal, urethral, and retroperitoneal locations.

  • Treatment

    Recommended treatment is the complete surgical excision with tumor-free margins and long-term follow-up exams. No indications for radiation and chemotherapy.

  • Outcome

    Follow-up is required because it may recur years after initial resection. No metastases have been observed.

Macroscopy

Macroscopic appearance is of a well-circumscribed, elastic-hard, slightly mobile mass whose size varies between 2.5 cm...

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References and Further Reading

  • Aydin, M., Uzuner, H., Akgunes, E., et al. (2017). Cellular angiofibroma of the spermatic cord. Aktuelle Urologie, 48(2), 159–160.

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  • Dikaiakos, P., Zizi-Sermpetzoglou, A., Rizos, S., & Marinis, A. (2011). Angiofibroma of the spermatic cord: A case report and a review of the literature. Journal of Medical Case Reports, 30(5), 423.

    Article  Google Scholar 

  • Iwasa, Y., & Fletcher, C. D. (2004). Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. The American Journal of Surgical Pathology, 28, 1426–1435.

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  • Laskin, W. B., Fetsch, J. F., & Mostofi, F. K. (1998). Angiomyofibroblastomalike tumor of the male genital tract: Analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 22, 6–16.

    Article  CAS  Google Scholar 

  • Nucci, M. R., Granter, S. R., & Fletcher, C. D. (1997). Cellular angiofibroma: A benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 21, 636–644.

    Article  CAS  Google Scholar 

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Correspondence to Alessandro Franchi .

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Gaeta, R., Franchi, A. (2019). Spermatic Cord Cellular Angiofibroma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4942-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4942-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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