Synonyms
Definition
Rare, circumscribed, slow-growing, benign mesenchymal tumor whose suggested histogenesis is perivascular stem cells.
Clinical Features
Incidence
Very low. About 60 cases of cellular angiofibroma in male genitourinary system are reported in English literature.
Age
It affects adults usually over 50 years of age.
Site
In men, cellular angiofibroma is observed in the inguino-scrotal region (paratesticular, tunica vaginalis, epididymis, and spermatic cord). There are rare reports of perineal, urethral, and retroperitoneal locations.
Treatment
Recommended treatment is the complete surgical excision with tumor-free margins and long-term follow-up exams. No indications for radiation and chemotherapy.
Outcome
Follow-up is required because it may recur years after initial resection. No metastases have been observed.
Macroscopy
Macroscopic appearance is of a well-circumscribed, elastic-hard, slightly mobile mass whose size varies between 2.5 cm...
References and Further Reading
Aydin, M., Uzuner, H., Akgunes, E., et al. (2017). Cellular angiofibroma of the spermatic cord. Aktuelle Urologie, 48(2), 159–160.
Dikaiakos, P., Zizi-Sermpetzoglou, A., Rizos, S., & Marinis, A. (2011). Angiofibroma of the spermatic cord: A case report and a review of the literature. Journal of Medical Case Reports, 30(5), 423.
Iwasa, Y., & Fletcher, C. D. (2004). Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. The American Journal of Surgical Pathology, 28, 1426–1435.
Laskin, W. B., Fetsch, J. F., & Mostofi, F. K. (1998). Angiomyofibroblastomalike tumor of the male genital tract: Analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 22, 6–16.
Nucci, M. R., Granter, S. R., & Fletcher, C. D. (1997). Cellular angiofibroma: A benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 21, 636–644.
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Gaeta, R., Franchi, A. (2019). Spermatic Cord Cellular Angiofibroma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4942-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4942-1
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