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Angiosarcoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 61 Accesses

Synonyms

Hemangiosarcoma; Malignant hemangioendothelioma

Definition

Angiosarcoma (AS) is a malignant tumor of endothelial cells.

Clinical Features

  • Incidence

    AS of the urogenital tract is very rare, with most studies consisting of single case reports. A weak association with previous radiotherapy has been reported.

  • Age

    It occurs in adult and elderly patients.

  • Sex

    AS of the kidney occurs more frequently in males than females (M:F = 7:1).

  • Site

    Urogenital angiosarcomas arise more frequently in the kidney and prostate. Rare cases have been described in the ureter, the bladder, the epididymis, and the penis.

  • Treatment

    Surgery is the primary treatment, with radiotherapy and chemotherapy employed in approximately 30% of the patients.

  • Outcome

    AS is a high-grade tumor with frequent local relapse and lymph node and distant metastases. The lungs and liver are the most common sites of metastasis.

Macroscopy

Grossly, the tumor presents as an ill-defined, invasive hemorrhagic mass often with areas of...

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References and Further Reading

  • Abarzua-Cabezas, F., Earle, J., & Meraney, A. (2014). Angiosarcoma of the corpora cavernosa. International Journal of Urology, 21, 622–623.

    Article  Google Scholar 

  • Brown, J. G., Folpe, A. L., Rao, P., Lazar, A. J., Paner, G. P., Gupta, R., Parakh, R., Cheville, J. C., & Amin, M. B. (2010). Primary vascular tumors and tumor-like lesions of the kidney: A clinicopathologic analysis of 25 cases. The American Journal of Surgical Pathology, 34, 942–949.

    Article  Google Scholar 

  • Gogoi, D., Hazra, S., Ghosh, B., & Pal, D. (2013). Angiosarcoma of penis. BML Case Reports, 2013. pii: bcr2013200878.

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  • Hayn, M. H., Bastacky, S., & Franks, M. E. (2007). Epididymal angiosarcoma. Urology, 69, 576.e5–576.e7.

    Article  Google Scholar 

  • Omiyale, A. O., & Carton, J. (2018). Clinical and pathologic features of primary Angiosarcoma of the kidney. Current Urology Reports, 19, 4.

    Article  Google Scholar 

  • Padaki, P., Hutton, R., Amer, T., Hasan, R., Pugh, D., & Little, B. (2016). A rare case of primary epithelioid angiosarcoma of the ureter. Annals of the Royal College of Surgeons of England, 98, e184–e185.

    Article  CAS  Google Scholar 

  • Seethala, R. R., Gomez, J. A., & Vakar-Lopez, F. (2006). Primary angiosarcoma of the bladder. Archives of Pathology & Laboratory Medicine, 130, 1543–1547.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

Authors
  1. Alessandro Franchi
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Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Franchi, A. (2019). Angiosarcoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4780-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4780-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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