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Atypical Adenomatous Hyperplasia: Lung

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Atypical alveolar cell hyperplasia; Atypical alveolar epithelial hyperplasia; Atypical alveolar hyperplasia; Atypical bronchioloalveolar cell hyperplasia; Bronchial adenoma

Definition

Atypical adenomatous hyperplasia (AAH) is a localized proliferation of mild to moderately atypical alveolar lining cells and/or Clara cells occurring in the peribronchiolar, centriacinar region of the parenchymal lung. Lesions are usually, though not exclusively, less than 5 mm in diameter (Figs. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11).

Fig. 1
figure 1

Occasionally, larger AAH lesions may be visible on the cut surface of the lung. Lung needs to be well inflated, fixed, and sliced for the lesions to be visualized. Not all such foci will be AAH

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References and Further Reading

  • Chapman, A. D., & Kerr, K. M. (2000). The association between atypical adenomatous hyperplasia and primary lung cancer. British Journal of Cancer, 83, 632–636.

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  • Kerr, K. M. (2013). Pulmonary pre-invasive disease. In P. S. Hasleton & D. Flieder (Eds.), Spencer’s pathology of the lung. Cambridge, UK: Cambridge University press.

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  • Selamat, S. A., Galler, J. S., Joshi, A. D., et al. (2011). DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PloS One, 6(6), e21443.

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  • Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.

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  • Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.

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Authors and Affiliations

  1. Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, AB25 2ZD, Aberdeen, UK

    Keith M Kerr & Andrea Chapman

Authors
  1. Keith M Kerr
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  2. Andrea Chapman
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Corresponding author

Correspondence to Keith M Kerr .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Kerr, K.M., Chapman, A. (2017). Atypical Adenomatous Hyperplasia: Lung. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4325-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4325-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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