Abstract
In this chapter, we present an alternative management of ipsilateral breast tumor recurrence following conservation therapy for early breast cancer. We will present the evidence to date and hope to establish this alternative approach as a plausible option for women affected by in-breast recurrence, but desirous of breast preservation. We discuss this option presenting the established standard of care and the alternatives, as well as the specific concerns related to retreatment.
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References
International Agency for Research on Cancer: Globocan 2012 http://globocan.iarc.fr/Default.aspx
Glass A, Lacey J, Carreon J et al (2007) Breast cancer incidence, 1980–2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst 99:1152–1161
World Health Organization Global Health Initiative. 2014. http://who.int/cancer/detection/breastcancer/en/index1.html
Bartelink H, Horiot JC, Poortmans PM (2007) Impact of a higher radiation dose on local control and survival in breast conserving therapy of early breast cancer: 10 year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol 25:3259–3265
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Darby S, McGale P, Correa C et al (2011) Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15 year breast cancer death: meta-analysis of individual patient data for 10801 women in 17 randomized trials. Lancet 378(9804):1707–1716
Poetter R, Gnant M, Kwasny W et al (2007) Lumpectomy plus tamoxifen or anastrozole with or without whole breast radiation in women with favorable early breast cancer. Int J Radiat Oncol Biol Phys 68(2):334–340
Fisher B, Anderson S, Bryant J et al (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy. And lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347:1233–1241
Veronesi U, Cascinelli N, Mariani L et al (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347:1227–1232
Abner AL, Recht A, Eberlein T et al (1993) Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early-stage breast cancer. J Clin Oncol 11:44–48
Ries LAG, Miller BA, Hankey BF et al (1994) SEER cancer statistics review, 1973-1991: tables and graphs. NIH publ no. 94-2789. USDHHS National Cancer Institute, Bethesda
Ganz P, Coscarelli A, Schag C et al (1992) Breast conservation versus mastectomy; is there a difference in psychological adjustment or quality of life in the year after surgery? Cancer 69:1729–1738
Rowland J, Desmond K, Meyerowitz B et al (2000) Role of breast reconstruction in physical and emotional outcomes among breast cancer survivors. J Natl Cancer Inst 92:1422–1429
Maunsell E, Brisson J, Deschhes L (1989) Psychological distress after initial treatment for breast cancer: a comparison of partial and total mastectomy. J Clin Epidemiol 42:765–771
RTOG 1014. Radiation therapy in treating women with locally recurrent breast cancer previously treated with repeat breast-preserving surgery. http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx?study=1014
Salvadori B, Marubini E, Miceli R et al (1999) Reoperation for locally recurrent breast cancer in patients previously treated with conservative surgery. Br J Surg 86:84–87
Komoike Y, Motomura K, Inaji H et al (2003) Repeat lumpectomy for patients with ipsilateral breast tumor recurrence after breast conserving surgery. Oncology 64:1–6
Huang E, Bucholz T, Meric F et al (2002) Classifying local disease recurrences after breast conservation therapy based on location and histology. Cancer 95(10):2059–2067
Doyle T, Schultz D, Peters C et al (2001) Long-term results of local recurrence after breast conservation treatment for invasive breast cancer. Int J Radiat Oncol Biol Phys 51(1):74–80
Cajucom C, Tsangaris T, Nemoto T et al (1993) Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy. Cancer 57(5):1174–1779
Recht A, Schnitt SJ, Connolly JL et al (1989) Prognosis following local or regional recurrence after conservative surgery and radiotherapy for early stage breast cancer. Int J Radiat Oncol Biol Phys 16:3–9
Fowble B, Solin L, Schultz D et al (1990) Breast recurrence following conservative surgery and radiation: patterns of failure, prognosis, and pathologic findings from mastectomy specimens with implications for treatment. Int J Radiat Oncol Biol Phys 19:833–842
Kurtz JM, Spitalier JM, Amalric R (1988) Results of salvage surgery for mammary recurrence following breast conserving therapy. Ann Surg 207:347–351
Trombetta M, Julian TB, Bhandari T et al (2008) Breast conservation surgery and interstitial brachytherapy in the management of locally recurrent carcinoma of the breast: the Allegheny General Hospital experience. Brachytherapy 7(1):29–36
Trombetta M, Julian TB, Kim Y et al (2012) Mature follow-up of low dose rate brachytherapy following ipsilateral breast tumor recurrence in patients initially treated with breast conservation therapy. J Solid Tumors 2(1):8–15
Fyles AW, McCready DR, Manchul LA et al (2004) Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 351:963–970
Hughes KS, Schnaper LS, Berry D et al (2004) Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 351:971–977
Kunkler IH, Williams LJ, Jack WJ et al (2015) Breast conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomized controlled trial. Lancet Oncol 16:266–273
Wong JS, Kaelin CM, Troyan SL et al (2006) Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol 24:1031–1036
Fong J, Kurniawan ED, Rose AK et al (2011) Outcomes of screening-detected ductal carcinoma in situ treated with wide excision alone. Ann Surg Oncol 18:3778–3784
Silverstein MJ, Poller DN, Waisman JR et al (1996) A prognostic index for ductal carcinoma of the breast. Cancer 77:2267–2274
Hughes LL, Wang M, Page DL et al (2009) Local excision alone without irradiation for ductal carcinoma in situ of the breast: a trial of the eastern Cooperative Group. J Clin Oncol 27(32):5319–5324
Wapnir I, Dignam J, Fisher E et al (2011) Long term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 clinical trials for DCIS. J Natl Cancer Inst 103(6):478–488
Correa C, McGale P, Taylor C et al (2010) Overview of the randomized trials of radiotherapy in ductal carcinoma in-situ of the breast. J Natl Cancer Inst Monogr 41:162–177
Strnad V, Van Limbergen E, Hannoun-Levi JM et al., on behalf of Working Group Breast Cancer of GEC-ESTRO (2015) Recommendations from GEC ESTRO Breast Cancer Working Group (I): target definition and target delineation for accelerated or boost Partial Breast Irradiation using multicatheter interstitial brachytherapy after breast conserving closed cavity surgery. Radiother Oncol. 115(3):342–348. doi: 10.1016/j.radonc.2015.06.010. Epub 2015 Jun 20
Pierquin B, Dutreix A, Paine CH et al (1978) The Paris system in interstitial radiation therapy. Acta Radiol Oncol Radiat Phys Biol 17:33–48
Mullen E, Deutsch M, Bloomer WD et al (1997) Salvage radiotherapy for local failures of lumpectomy and breast irradiation. Radiother Oncol 42:25–29
Deutsch M (2002) Repeat high-dose external beam irradiation for in-breast tumor recurrence after previous lumpectomy and whole breast irradiation. Int J Radiat Oncol Biol Phys 53(3):687–691
Chadha M, Feldman S, Boolbol S et al (2008) The feasibility of a second lumpectomy and breast brachytherapy for localized cancer in a breast previously treated with lumpectomy and radiation therapy for breast cancer. Brachytherapy 7:22–28
Hannoun-Levi JM, Houvenaeghel G, Ellis S et al (2004) Partial breast irradiation as second conservative treatment for local breast cancer recurrence. Int J Radiat Oncol Biol Phys 60(5):1385–1392
Maulard C, Housset M, Brunel P et al (1995) Use of perioperative or split-course interstitial brachytherapy techniques for salvage irradiation of isolated local recurrences after conservative management of breast cancer. Am J Clin Oncol 18:348–352
Kauer-Dorner D, Pötter R, Resch A et al (2012) Partial breast irradiation for locally recurrent breast cancer within a second breast conserving treatment: alternative to mastectomy? Results from a prospective trial. Radiother Oncol 102:96–101
Guix B, Lejárcegui JA, Tello JI et al (2010) Exeresis and brachytherapy as salvage treatment for local recurrence after conservative treatment for breast cancer: results of a ten-year pilot study. Int J Radiat Oncol Biol Phys 78:804–810
Hannoun-Levi JM, Castelli J, Plesu A et al (2011) Second conservative treatment for ipsilateral breast cancer recurrence using high-dose rate interstitial brachytherapy: preliminary clinical results and evaluation of patient satisfaction. Brachytherapy 10:171–177
Hannoun-Levi JM, Resch A, Gal J, Kauer-Dorner D, Strnad V, Niehoff P, Loessl K, Kovács G, Van Limbergen E, Polgár C, GEC-ESTRO Breast Cancer Working Group (2013) Accelerated partial breast irradiation with interstitial brachytherapy as second conservative treatment for ipsilateral breast tumour recurrence: multicentric study of the GEC-ESTRO Breast Cancer Working Group. Radiother Oncol 108:226–231
Beitch P, Wilkinson JB, Vicini F et al (2012) Tumor bed control with balloon-based accelerated partial breast irradiation: Incidence of true recurrence versus elsewhere failures in the American Society of Breast Surgery MammoSite® Registry trial. Ann Surg Oncol 19(10):3165–3170
Yi M, Buchholz TA, Meric-Bernstam F et al (2011) Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning. Ann Surg 253:572–579
Trombetta M, Julian TB, Miften M et al (2008) The use of the MammoSite® balloon applicator in re-irradiation of the breast. Brachytherapy 316–319
Smith B, Arthur D, Buchholz T et al (2009) Accelerated partial breast irradiation consensus statement from the American Society for radiation oncology. Int J Radiat Oncol Biol Phys 74(4):387–1001
Shah C, Vicini F, Wazer D et al (2013) The American brachytherapy society consensus statement for accelerated partial breast irradiation. Brachtherapy 12:267–277
Chadha M, Trombetta M, Boolbol S, Osborne M (2009) Managing a small recurrence in the previously irradiated breast: is there a second chance for breast conservation? Oncology 23(11):933–940
Kim Y, Trombetta M (2014) Dosimetric evaluation of multilumen intracavitary balloon rotation in HDR brachytherapy for breast cancer. J Appl Clin Med Phys 15(1):4429
Common Terminology Criteria for Adverse Events (version 4.03). http://evs.nci.nih.gov/ftp1/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf
NSABP protocol B-39 form COS. http://www.rtog.org/members/protocols/0413/0413.pdf58
Trombetta M, Julian TB, Kim Y, Werts D, Parda D (2009) The allegheny general modification of the harvard breast cosmesis scale for the retreated breast. Oncology 23(11):954–956
Trombetta M, Valakh V, Julian TB et al (2010) Mammary fat necrosis in the conservative management of localized breast cancer: does it matter? Radiother Oncol 97(1):92–94
Valakh V, Kim Y, Werts ED et al (2012) A comprehensive analysis of cardiac dose in balloon-based high dose rate brachytherapy for left sided breast cancer. Int J Radiat Oncol Biol Phys 82(5):1698–1705
Croshaw R, Kim Y, Kim E et al (2011) Avoiding Mastectomy: accelerated partial breast irradiation for breast cancer patients with pacemakers or defibrillators. Ann Surg Oncol 18(12):3500–3505
Kim Y, Arshoun Y, Trombetta M (2012) Pacemaker/implantable cardioverter/defibrillator dose in high dose rate brachytherapy for breast cancer. Brachytherapy 11:380–386
Panet-Raymond V, Truong PT, McDonald RE et al (2011) True recurrence versus new primary: an analysis of ipsilateral breast tumor recurrences after breast conserving therapy. Int J Radiat Oncol Biol Phys 81:409–417
Kurtz JM, Jacquemier J, Amalric R et al (1991) Is breast conservation after local recurrence feasible? Eur J Cancer 27:240–244
Bollet MA, Servant N, Neuvial P et al (2008) High-resolution mapping of DNA breakpoints to define true recurrences among ipsilateral breast cancers. J Natl Cancer Inst 100:48–58
Vicini FA, Antonucci JV, Goldstein N et al (2007) The use of molecular assays to establish definitively the clonality of ipsilateral breast tumor recurrences and patterns of in-breast failure in patients with early-stage breast cancer treated with breast-conserving therapy. Cancer 109:1264–1272
Alpert TE, Kuerer HM, Arthur DW et al (2005) Ipsilateral breast tumor recurrence after breast conservation therapy: outcomes of salvage mastectomy vs. salvage breast-conserving surgery and prognostic factors for salvage breast preservation. Int J Radiat Oncol Biol Phys 63:845–851
Chen SL, Martinez SR (2008) The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence. Am J Surg 196:495–499
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Trombetta, M., Julian, T.B., Hannoun-Levi, JM. (2016). Breast Brachytherapy: Brachytherapy in the Management of Ipsilateral Breast Tumor Recurrence. In: Montemaggi, P., Trombetta, M., Brady, L. (eds) Brachytherapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-26791-3_11
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DOI: https://doi.org/10.1007/978-3-319-26791-3_11
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