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Lanostanoids from Fungi as Potential Medicinal Agents

  • Reference work entry
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Fungal Metabolites

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as cytotoxicity, immunomodulation, and anti-inflammation. Some of them also have interesting effects on metabolism and anti-infectious properties. This review will compile chemical data, biological effects, and mechanisms on the most relevant lanostanoids isolated from fungi, such as those from Ganoderma lucidum, Poria cocos, Laetiporus sulphureus, Inonotus obliquus, Antrodia camphorata, Daedalea dickinsii, and other.

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Abbreviations

ABCB:

ATP-binding cassette

AIF:

Apoptosis-inducing factor

AKT:

Protein kinase B

AMPK:

AMP-activated kinase

C/EBPα:

CCAAT-enhancer-binding protein-α

CCAAT:

Cytosine-cytosine-adenosine-adenosine-thymidine

cdk4:

Cyclin D kinase 4

COX:

Cyclooxygenase

CYP3A4:

Cytochrome P450 3A4

DBD:

DNA-binding domain

DMBA:

7,12-Dimethylbenz[a]anthracene

EBV-EA:

Epstein-Barr virus early antigen

ERK Erk:

Extracellular-regulated kinase

FXR:

Farnesoid X receptor

GLUT4:

Glucose transporter type 4

GPDH:

Glycerol-3-phosphate dehydrogenase

HIV:

Human immunodeficiency virus

HO-1:

Heme-oxygenase-1

hPXR:

Human pregnane X receptor

IC50 :

Inhibitory concentration 50

IFN-γ:

Interferon-γ

IL:

Interleukin

iNOS:

Inducible nitric oxide synthase

IRS-1:

Insulin receptor substrate-1

IκBα:

Inhibitor of κBα

JAK:

Janus kinase

JNK:

c-Jun N-terminal kinase

LBD:

Ligand-binding domain

LPS:

Lipopolysaccharide

MDD:

Mean day of death

MIC:

Minimum inhibitory concentration

MMP-9:

Matrix metalloproteinase-9

NF-κB:

Nuclear factor-κB

NK:

Natural killer

NO:

Nitric oxide

Nrf2:

Nuclear factor (erythroid-derived 2)-like 2

PI3K:

Phosphatidylinositol-4,5-bisphosphate 3-kinase

PLA2 :

Phospholipase A2

PARP:

Poly(ADP-ribose)-polymerase

PPAR-γ:

Peroxisome proliferator-activated receptor-γ

RXR:

Retinoid X receptor

SREBP-1c:

Sterol regulatory element-binding protein-1c

STAT3:

Signal transducer and activator of transcription 3

T2DM:

Type 2 diabetes mellitus

TNFα:

Tumor necrosis factor-α

TPA:

12-O-Tetradecanoylphorbol-13-acetate

uPA:

Urokinase-type plasminogen activator

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Authors and Affiliations

  1. Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100, Burjassot, Valencia, Spain

    José-Luis Ríos

  2. I.U. de Conservación y Mejora de la Agrodiversidad Valenciana (COMAV), Camino de Vera s/n Building 8E - Access I, Ciudad Politécnica de la Innovación, 46022, Valencia, Spain

    Isabel Andújar

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  1. Faculty of Pharmaceutical Sciences, University of Bordeaux, Bordeaux, France

    Jean-Michel Mérillon

  2. Botany Department, M.L.Sukhadia University, Udaipur, Rajasthan, India

    Kishan Gopal Ramawat

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Ríos, JL., Andújar, I. (2017). Lanostanoids from Fungi as Potential Medicinal Agents. In: Mérillon, JM., Ramawat, K. (eds) Fungal Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-25001-4_19

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