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Connective Tissue Disease pp 309–317Cite as

Parotid and Submandibular Involvement in Sjögren’s Syndrome

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Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

Sjögren’s syndrome (SS) is a chronic autoimmune condition characterized by diminished lacrimal and salivary gland function with associated lymphocytic infiltrates of the affected glands. SS may occur in a primary form when it is not associated with other autoimmune disorders or in a secondary form when it complicates another underlying rheumatic disease. Among others, rheumatoid arthritis and systemic lupus erythematosus are the most common diseases associated with SS.

Reduced exocrine gland function is the main pathogenic mechanism underlying the principal clinical manifestations of SS, such as a combination of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Salivary gland enlargement is common and occurs in 30–50 % of patients with SS at some point during the course of the disease.

This chapter will focus on parotid and submandibular involvement in Sjögren’s syndrome.

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Authors and Affiliations

  1. Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network of Rare Diseases of Piedmont and Aosta Valley, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Piazza del donatore di Sangue 3, Turin, 10154, Italy

    Savino Sciascia & Dario Roccatello

  2. Pathology Department, Giovanni Bosco Hospital, Piazza del donatore di Sangue 3, Turin, 10154, Italy

    Andrea De Marchi

  3. SCDU Nephrology and Dialysis, Giovanni Bosco Hospital and University of Turin, Piazza del donatore di Sangue 3, Turin, 10154, Italy

    Dario Roccatello

Authors
  1. Savino Sciascia
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  2. Andrea De Marchi
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  3. Dario Roccatello
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Correspondence to Dario Roccatello .

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Editors and Affiliations

  1. Giovanni Bosco Hospital, Center of Immunopathology/Rare Dise, Torino, Torino, Italy

    Dario Roccatello

  2. University of Florence, Florence, Italy

    Lorenzo Emmi

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Sciascia, S., De Marchi, A., Roccatello, D. (2016). Parotid and Submandibular Involvement in Sjögren’s Syndrome. In: Roccatello, D., Emmi, L. (eds) Connective Tissue Disease. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-24535-5_22

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  • DOI: https://doi.org/10.1007/978-3-319-24535-5_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24533-1

  • Online ISBN: 978-3-319-24535-5

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