Skip to main content

Galeola to Gymadenia

  • Chapter
  • First Online:
  • 1299 Accesses

Abstract

Gastrodia elata (Tianma) is the most important species of orchid used in traditional medicine. It is the principal herb used for the prevention and treatment of strokes and for neurological disorders which include Parkinsonism and dementia. Gastrodia elata is present in many patent Chinese herbal remedies. More than 50 compounds have been isolated from this orchid. Their neuro-protective and other effects, and those of crude Gastrodia elata extracts are extensively discussed in this chapter. Chinese scientists have also discovered a way to cultivate the orchid. Other orchid genera described in this chapter are Galeola, Gastrochilus, Geodorum, Goodyera, Grammatophyllum and Gymadenia. Examples are provided on how these orchids are used in Traditional Chinese Medicine and other traditions.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Aasen A, Behr D, Leander K (1975) Studies on Orchidaceae Gylcosides 2. The structure of loroglossin and militarine, two glycosides from Orchis militaris L. Acta Chem Scand 29b:1002–1004

    Google Scholar 

  • Abraham A, Vatsala P (1981) Introduction to Orchids, with illustrations and descriptions of 150 South Indian Orchids. TPGRI, Trivandrum

    Google Scholar 

  • Ahn EK, Jeon HJ, Lim EJ, Jung HJ, Park EH (2007) Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol 110(3):476–482

    Article  PubMed  Google Scholar 

  • An SJ, Park SK, Hwang IK et al (2003) Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure sensitive gerbils. J Neurosci Res 71(4):534–543

    Article  CAS  PubMed  Google Scholar 

  • An SM, Park CH, Heo JC et al (2007) Gastrodia elata Blume protects against stress- induced gastric mucosal lesions in mice. Intern J Mol Med 20(2):209–215

    Google Scholar 

  • Anderson M, Bergendorff O, Nielsen M et al (1995) Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry 38(4):835–836

    Article  Google Scholar 

  • Anonymous (1989) Medicinal plants of China. Selection of 150 commonly used species. WHO pacific series no. 2. Regional Office of the Pacific, Manila

    Google Scholar 

  • Baek NI, Choi SY, Park JK (1999) Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. Arch Pharm Res 22(2):219–224

    Article  CAS  PubMed  Google Scholar 

  • Baral SR, Kurmi PP (2006) A compendium of medicinal plants in Nepal. Rachana Sharma, Kathmandu, IUCN

    Google Scholar 

  • Beekman EM (2002) (transl., ed) Rumphius Orchids. Orchid Texts from the Ambonese Herbal by Georgius Everhardus Rumphius. Yale University Press, New Haven

    Google Scholar 

  • Bensky D, Clavey S, Stoger E, Gambie A (2004) Herbal medicine materia medica, 3rd edn. Eastland Press, Seattle, WA

    Google Scholar 

  • Benzing DH (1987) Major patterns and processes in orchid evolution. In: Arditti J (ed) Orchid biology. Reviews & perspectives IV. Cornell University Press, Ithaca, NY

    Google Scholar 

  • Bie X, Chen Y, Han J et al (2007) Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pac J Clin Nutr 16(Suppl 1):305–8

    CAS  PubMed  Google Scholar 

  • Bin-Jaliah I (2008) Comparison of glutathione peroxidase activity and free radicals production in the lungs and the brain of rats during graded hyperoxia. J Med Sci 8(1):54–61

    Article  CAS  Google Scholar 

  • Bose TK, Bhattacharjee SK (1980) Orchids of India. Naya Prokash, Calcutta

    Google Scholar 

  • Burkill IH (1935) (1966 reprint, 2nd edn, with contributions by Birtwistle W, Foxworthy FW, Scrivenor JB, Watson IG) A dictionary of economic products of the Malay Peninsula, vol II. Crown Agents for the Colonies, London. Ministry of Agriculture & Co-operatives, Kuala Lumpur

    Google Scholar 

  • Cai M, Zhou Y, Gesang S et al (2006) Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. J Chromatogr B Analyt Technol Biomed Life Sci 844(2):301–307

    Article  CAS  PubMed  Google Scholar 

  • Cai Z, Hou S, Li Y et al (2008a) Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. J Drug Target 16(2):178–184

    Article  CAS  PubMed  Google Scholar 

  • Cai Z, Hou SX, Yang ZX et al (2008b) Brain targeting of gastrodin nasal in situ gel. Sichuan Da Xue Xue Bao Yi Xue Ban 39(3):438–440

    CAS  PubMed  Google Scholar 

  • Cameron DD, Johnsson I, Leake JR, Read DJ (2007) Mycorrhizal acquisition of inorganic phosphorus by the green-leaved terrestrial orchid Goodyera repens. Ann Bot (Lond) 99(5):831–834

    Article  CAS  Google Scholar 

  • Chen WC, Tseng TS, Hsiao NW, et al (2015) Discovery of highly potent tyrosine inhibitor, T1 with significant anti-melanogenesis ability by zebra-fish in vivo assay and computational molecular modeling. Sci Reports, 5 Article No: 7995

    Google Scholar 

  • Cheam MC (ed) (2009) Wild orchids of Cameron Highlands. Regional Environmental Awareness Cameron Highlands, Cameron Highlands

    Google Scholar 

  • Chen SC, Tang T (1982) A general review of the orchid flora of China. In: Arditti J (ed) Orchid biology. Reviews and perspectives II. Cornell University Press, Ithaca

    Google Scholar 

  • Chen SC, Tsi ZH, Luo YB (1999) Native orchids of China in colour. Science Press, Beijing

    Google Scholar 

  • Chen PJ, Hsieh CL, Su KP et al (2008) The antidepressant effect of Gastrodia elata on the forced swimming test in rats. Am J Chin Med 36:95–106

    Article  CAS  PubMed  Google Scholar 

  • Chen PJ, Hsieh CL, Su KP et al (2009) Rhizomes of Gastrodia elata Bl. poosses antidepressant-like effect via Monoamine Modulation in Sub-chronic Animal Model. Am J Chin Med 36:1113–1124

    Article  Google Scholar 

  • Chen XQ, Lang KY, Gale SW et al (2009a) Goodyera R. Br. In: Chen XQ, Liu ZJ, Zhu GH et al (eds) Flora of China—Orchidaceae. Science Press, Beijing, pp 45–54

    Google Scholar 

  • Chen XQ, Cribb PJ, Gale SW (2009b) Geodorum Jackson. In: Chen XQ, Zj L, Zhu GH et al (eds) Flora of China—Orchidaceae. Science Press, Beijing

    Google Scholar 

  • Chen XQ, Gale SW, Cribb PJ (2009c) Gymadenia R. Br. In: Chen XQ, ZJ L, Zhu GH et al (eds) Flora of China—Orchidaceae. Science Press, Beijing

    Google Scholar 

  • Chen YY, Bao ZX, Li ZZ (2011) High allozymic diversity in natural populations of mycoheterotrophic orchid Gastrodia elata, an endangered medicinal plant in China. Biochem Syst Ecol 39(4–6):526–535

    Article  CAS  Google Scholar 

  • Chen X, Cao DX, Zhou L et al (2011) Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities. Carbohydr Polym 86(3):1300–1305

    Article  CAS  Google Scholar 

  • Chen CL, Young SH, Gan HH et al (2013) Chinese medicine neuroaid efficacy on stroke recovery: a double blind, placebo-controlled randomized study. Stroke 44(8):2093–2100

    Article  CAS  PubMed  Google Scholar 

  • Chen YY, Bao ZX, Qu Y, Li W (2014a) Genetic diversity and population structure of the medicinal orchid Gastrodia elata revealed by microsatellite analysis. Biochem Syst Ecol 54:182–189

    Article  CAS  Google Scholar 

  • Chen Y-Y, Bao Z-X, Qu Y, Li Z-Z (2014b) Genetic variation in cultivated populations of Gastrodia elata, a medicinal plant from central China analyzed by microsatellites. Genet Res Crop Evol 61(8):1523–1532

    Article  Google Scholar 

  • Chiou SJ, Yen JH, Fang CL et al (2007) Authentication of medicinal herbs using PCR-amplified ITS2 with specific primers. Planta Med 73:1421–1426

    Article  CAS  PubMed  Google Scholar 

  • Choi JH, Lee DU (2006) A new citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase. Chem Pharm Bull (Tokyo) 54:1720–1721

    Article  CAS  Google Scholar 

  • Choo CM, van der Ent A, Abdullah E, Perumal B (2009) Wild orchids of Cameron Highlands. Regional Environmental Awareness Cameron Highlands, Cameron Highlands, Malaysia

    Google Scholar 

  • Chow S, Chen SC (1983) Notes on Chinese Gastrodia. Acta Bot Yunnanica 5(4):361–368

    Google Scholar 

  • Christian P (1975) Creeping ladies’ tresses. Alpine Gard Soc Great Britain Quart Bull 43(4):322–324

    Google Scholar 

  • Chuakul W (2002) Ethnomedical uses of Thai orchidaceous plants. Mahidol Univ J Pharm Sci 29(3–4):41–45

    Google Scholar 

  • Cox KD, Layne DR, Scorza R, Schnadbel G (2006) Gastrodia anti-fungal protein from the orchid Gastrodia elata confers disease resistance to root pathogens in transgenic tobacco. Planta 224(6):1373–1383

    Article  CAS  PubMed  Google Scholar 

  • Cribb P, Fischer E, Killmann D (2010) A revision of Gastrodia (Orchidaceae: Epidendroideae, Gastrodieae) in tropical Africa. Kew Bull 65(2):315–321

    Article  Google Scholar 

  • Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11(3):327–335

    Article  CAS  PubMed  Google Scholar 

  • Daduang S, Uawonggul N (2008) Herbal therapies of snake and insect bites in Thailand. In: Watson RR, Preedy VR (eds) Botanical medicine in clinical practice. CAB International, Wallingford, pp 814–822

    Google Scholar 

  • Dash PK, Sahon S, Bal S (2008) Ethnobotanical studies on orchids of Niyamgiri Hill Ranges, Orissa, India. Ethnobot Leaflets 12:70–78

    Google Scholar 

  • Davis RS, Steiner ML (1982) Philippine Orchids. A detailed treatment of some 100 native species. M & L Licudine Enterprises (reprint), Manila

    Google Scholar 

  • Descamps E, Petrault-Laprais M, Maurois P et al (2009) Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin. Neurosci Res 64(2):137–142

    Article  CAS  PubMed  Google Scholar 

  • Ding CS, Shen YS, Li G et al (2007) Study of a glycoprotein from Gastrodia elata: its effects of anticoagulation and antithrombosis. Zhongguo Zhong Yao Za Zhi 32(11):1060–1064

    PubMed  Google Scholar 

  • Du XM, Sun NY, Shoyama Y (2000) Flavonoids from Goodyera schlechtendaliana. Phytochemistry 53:997–1000

    Article  CAS  PubMed  Google Scholar 

  • Du XM, Sun NY, Chen Y, Irino N, Shoyama Y (2000a) Hepatoprotective aliphatic glycosides from three Goodyera species. Biol Pharm Bull 23(6):731–734

    Google Scholar 

  • Du XM, Sun NY, Takizawa N et al (2002) Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana. Phytother Res 16(3):261–263

    Article  CAS  PubMed  Google Scholar 

  • Du XM, Irino N, Furusho N, Hiyashi J, Shoyama Y (2008) Pharmacologically active compounds in the Anoectochilus and Goodyera species. Nat Med (Tokyo) 62(2):132–148

    Article  CAS  Google Scholar 

  • Duan N, Lu XQ (2006) Effects of drought on output of Gastrodia elata. Zhong Yao Cai 29(1):3–5

    PubMed  Google Scholar 

  • Fan LL, Dong YC, Xu TY et al (2013) Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium. Appl Biochem Biotechnol 170(1):138–148

    Article  CAS  PubMed  Google Scholar 

  • Fratkin J (1997) Chinese herbal patent formulas: a practical guide. Pelanduk Publications, Selangor, Darul Ehsan

    Google Scholar 

  • Fu JH, Du GY (2001) Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion. Zhongguo Zhong Yao Za Zhi 26(1):53–55

    CAS  PubMed  Google Scholar 

  • Fu XY, Li SM, Wang TT et al (2010) Antioxidation effects and mechanism of Gastrodin in AD rat models. Jiepou Xuebao 41(4):485–490

    CAS  Google Scholar 

  • Gan ZJ (1986) Processing of Gastrodia elata where it is produced. Zhong Yao Tong Bao 11(1):27–28

    CAS  PubMed  Google Scholar 

  • Griffith RE (1847) Medical botany of descriptions of the more important plants used in medicine, with their history, properties and mode of administration. Lea and Blanchard, Philadelphia

    Book  Google Scholar 

  • Gudmundsdottir KB, Kristinsson J, Sigurdarson S et al (2008) Glutathione peroxidase (GPX) activity in blood of ewes on farms in different scrapie categories in Iceland. Acta Veterinaria Scand 50:23

    Article  CAS  Google Scholar 

  • Guo Q, Wang Y, Lin S et al (2015) (2015): 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata. Acta Pharm Sin B 5(4):350–357

    Article  PubMed  PubMed Central  Google Scholar 

  • Guo S, Xu J (1990) Determination of primary metabolic products of fungi promoting seed germination of Gastrodia elata Bl. and other Orchidaceae medicinal plants. Zhongguo Zhong Yao Za Zhi 15(6):332–334

    CAS  PubMed  Google Scholar 

  • Guo Z, Tan T, Zhong Y, Wu C (1991a) Study of the mechanism of gastrodin and derivatives of gastrodigenin. Hua Xi Yi Ke Da Xue Xue Bao 22(1):79–82

    CAS  PubMed  Google Scholar 

  • Guo Z, Tan T, Zhong Y, Wu C (1991b) Study of the mechanism of gastrodin and derivatives of gastrodigenin. Xi Yi Ke Da Xue Xue Bao 22(1):79–82

    CAS  Google Scholar 

  • Guo JM, Pan WW, Qian DW et al (2014a) Analgesic activity of DaChuanXiongFang after intranasal administration and its potential active components in vivo. J Ethnopharmacol 150(2):649–654

    Article  CAS  Google Scholar 

  • Guo ZG, Jia XP, Su XJ et al (2014b) Gastrodin attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HTIA receptors. Bangladesh J Pharmacol 8(4):414–419

    Google Scholar 

  • Gurong DB (2006) An Illustrated guide to the Orchids of Bhutan. DSB Publications, Thimphu

    Google Scholar 

  • Ha JH, Lee DU, Lee JT et al (2000) 4-Hydroxybenzaldehyde from Gastrodia elata Bl. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol 73(1–2):329–333

    Article  CAS  PubMed  Google Scholar 

  • Ha JH, Shin SM, Lee SK et al (2001) In vitro effects of hydroxybenzylaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation. Planta Med 67(9):877–880

    Article  CAS  PubMed  Google Scholar 

  • Ha JH, Hayashi J, Sekine T, Deguchi S et al (2002) Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochemistry 59(5):513–519

    Article  Google Scholar 

  • Han BH, Suh Y, Chi HJ (1998) Medicinal plants of the Republic of Korea. WHO Regional Publications. Pacific Series No. 21. WHO, Manila

    Google Scholar 

  • Han YJ, Je JH, Kim SY et al (2014) Gastrodia elata shows neuroprotective effects via activation of P13K signaling against oxidative glutamate toxicity in HT22 cells. Am J Chin Med 42(4):1007–1019

    Article  PubMed  Google Scholar 

  • Hawkes AD (1953) Snippet. Orchid J 1(3):105

    Google Scholar 

  • Hayashi J, Sekine T, Deguchi S et al (2002) Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochemistry 59(5):513–519

    Article  CAS  PubMed  Google Scholar 

  • Heo JC, Woo SU, Son MS et al (2007) Anti-tumor activity of Gastrodia elata Blume is closely associated with GTP-Ras-dependent pathway. Oncol Rep 18(4):849–853

    PubMed  Google Scholar 

  • Heyne K (1927) De nuttige planten van Nederlandsche Indie, vol 1. Uitgave van het Departement van Landbouw, Nijverheid & Handel in Nederlandsche-Indie, pp 508–513

    Google Scholar 

  • Horner IB (ed) (1982) Book of discipline, vol I–IV. Pali Text Society, London

    Google Scholar 

  • Hsieh MT, Wu CR, Chen CF (1997) Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval but not acquisition, on the passive avoidance task in rats. J Ethnopharmacol 56(1):45–54

    Article  CAS  PubMed  Google Scholar 

  • Hsieh CL, Tang NY, Chiang SY et al (1999) Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (Miq) Jack and Gastrodia elata Bl., in kainic acid-treated rats. Life Sci 65(20):2071–2082

    Article  CAS  PubMed  Google Scholar 

  • Hsieh CL, Chang CH, Chiang SY et al (2000) Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Life Sci 67(10):1185–1195

    Article  CAS  PubMed  Google Scholar 

  • Hsieh CL, Chiang SY, Cheng KS et al (2001) Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl in kainic acid treated rats. Am J Chin Med 29(2):331–341

    Article  CAS  PubMed  Google Scholar 

  • Hsieh CL, Chen CL, Tang NY et al (2005) Gastrodia elata BL mediates suppression of nNOS and microglia activation t protect against neuronl damage in kainic-acid treated rats. Am J Chin Med 33(4):599–611

    Article  PubMed  Google Scholar 

  • Hsieh C, Lin JJ, Chiang SY et al (2007) Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signalling pathway in kainic acid-induced epilepsy in rats. J Ethnopharmacol 109(2):241–247

    Article  PubMed  Google Scholar 

  • Hsu TC, Kuo CM (2010) Supplements to the orchid flora of Taiwan (IV): four additions to the genus gastrodia. Taiwania 55(3):243–248

    Google Scholar 

  • Hu SY (2005) Food plants of China. The Chinese University Press, Hong Kong

    Google Scholar 

  • Hu JM, Zhou J (2010) Phytochemical progress at KIB of two species in orchidaceae—dendrobium and gastrodia. Recent Development in Chinese Herbal Medicine. Nanyang Technological University, p 90

    Google Scholar 

  • Hu XM, Zhang WK, Zhu QZ et al (2000) Zhonghua Bencao, vol 8. Shanghai Science and Technology Publication, Shanghai

    Google Scholar 

  • Hu JF, Li GZ, Li MJ (2003a) Protective effect of Gastrodia elata and E-gelatin on lead-induced damage to the structure and function of rat hippocampus. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Sa Zhi 21(2):124–127

    Google Scholar 

  • Hu JF, Li GZ, Li MJ (2003b) The antagonistic action of Gastrodia elata combined with E-gelatin on lead-induced down regulation of c-fos expression in rat brain. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Sa Zhi 21(2):128–131

    Google Scholar 

  • Hu JM, Zhao YX, Li N et al (2010) Pharmaceutical research of Gastrodia elata. Conference on Recent Development in Chinese Herbal Medicine. Nanyang Technological University, Singapore, 25–26 January 2010. Poster presentation, uncatalogued

    Google Scholar 

  • Huang JH (1989) Comparison studies of pharmacological properties of injection Gastrodia elata, gastrodin-free fraction and gastrodin. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 11:147–150

    CAS  PubMed  Google Scholar 

  • Huang SY, Shi JG, Yang YC, Hu SL (2002) Studies on chemical constituents from Tibetan medicine wangle (rhizome of Coeloglossum viride var. bracteatum). Zhongguo Zhong Yao Za Zhi 27(2):118–120

    CAS  PubMed  Google Scholar 

  • Huang NK, Lin YL, Cheng JJ, Lai WL (2004) Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life Sci 75(13):1649–1657

    Article  CAS  PubMed  Google Scholar 

  • Huang SY, Li GQ, Shi JG, Mo SY (2004) Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum. J Asian Nat Prod Res 6(1):49–61

    Article  CAS  PubMed  Google Scholar 

  • Huang ZB, Wu Z, Chen FK, Zou LB (2006) The protective effects of phenolic constituents from Gastrodia elata on the cytoxicity induced by KCl and glutamate. Arch Pharm Res 29:963–968

    Article  CAS  PubMed  Google Scholar 

  • Huang NK, Chern Y, Fang JM et al (2007) Neuroprotective principles from Gastrodia elata. J Nat Prod 70:571–574

    Article  CAS  PubMed  Google Scholar 

  • Huang CL, Yang JM, Wang KC et al (2011) Gastrodia elata prevents Huntington aggregations through activation of the adenosine A(2A) receptor and ubiquitin proteasome system. J Ethnopharm 138(1):162–168

    Article  Google Scholar 

  • Huang GB, Zhao T, Muna SS et al (2013) Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer’s disease. Neural Regen Res 8(1):1061–1070

    CAS  PubMed  PubMed Central  Google Scholar 

  • Huang LQ, Li ZF, Wang Q et al (2015) Two new furaldehyde compounds from the rhizomes of Gastrodia elata. J Asian Nat Prod Res 17(4):352–356

    Article  CAS  PubMed  Google Scholar 

  • Hwang SM, Lee YJ, Kang DG, Lee HS (2009) Anti-inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am J Chin Med 37:395–406

    Article  CAS  PubMed  Google Scholar 

  • Illum L (2004) Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol 56:3–17

    Article  CAS  PubMed  Google Scholar 

  • Imam SZ, El-Yazal J, Newport GD et al (2001) Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. Ann N Y Acad Sci 938:366–380

    Google Scholar 

  • Jain SP (2003) An inventory of threatened medicinal and aromatic plants of northwestern India. In: Singh V, Jain AP (eds) Ethnoboany and medicinal Plants of India and Nepal. Scientific Publishers (India), Jodhpur, pp 908–913

    Google Scholar 

  • Jang YW, Lee JY, Kim CJ (2009) Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Int Immunopharmacol 10(2):147–154

    Article  PubMed  CAS  Google Scholar 

  • Jersakova J, Castro S, Sonk N et al (2010) Absence of pollinator-mediated barriers in mixed-ploidy populations of Gymnadenia conopsea s.l. (Orchidaceae). Evol Ecol 24(5):1199–1218

    Article  Google Scholar 

  • Ji N, Li Y (2009) Effect of different strains of Armillaria mellea on the yield of Gastrodia elata f. glauca. J Fungal Res 6(4):231–233

    Google Scholar 

  • Ji XH, Li N, Wang JR, Zhang YJ (2008) Fingerprint identification between gastrodia elata Blume and its counterfeits with infrared spectroscopy. Xibei Zhiwu Xuebao 28:831–835

    CAS  Google Scholar 

  • Ji W, Chen L, Ma X, et al (2014) Molecularly imprinted polymers with novel functional monomer for selective solid-phase extraction of gastrodin from the aqueous extract of Gastrodia elata

    Google Scholar 

  • Jiang L, Wan S, Wang S, Yu C (2001) Isoenzyme analysis of Gastrodia elata f. elata and G. elata f. glaucca and their hybrid. Zhong Yao Cai 24:547–548

    CAS  PubMed  Google Scholar 

  • Jiang L, Dai J, Huang Z et al (2013) Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci 915–916:8–12

    Article  PubMed  CAS  Google Scholar 

  • Jiang GL, Wu HY, Hu YQ et al (2014) Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signalling cascade. Cell Mol Neurobiol 34(4):591–602

    Article  CAS  PubMed  Google Scholar 

  • Jin XH, Zhao XD, Shi XC (2009) Native Orchids from Gaoligongshan Mountains, China. Science Press, Beijing

    Google Scholar 

  • Joseph J (1982) Orchids of Nilgiris, vol XXII, Records of the botanical survey of India. Botanical Survey of India (Department of Environment), Howrah

    Google Scholar 

  • Jung JW, Yoon BH, Oh HR et al (2006) Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol Pharm Bull 29:261–265

    Article  CAS  PubMed  Google Scholar 

  • Jung TY, Suh SI, Lee H et al (2007) Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. Phytother Res 21(10):960–964

    Article  PubMed  Google Scholar 

  • Kaengkan P, Baek SE, Ji YK et al (2013) Administration of mesenchymal stem cells and ziprasidone enhance amelioration of ischemic brain damage in rats. Mol Cells 36(6):534–541

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaiser R (1993) The scent of orchids: olfactory and chemical investigations. Editiones Roche, Basel

    Book  Google Scholar 

  • Kanda K (1977) The native orchids of Japan. Seibundo-Shinkosha, Tokyo

    Google Scholar 

  • Kang OS, Doo AR, Kim SN, et al (2014) Gastrodia elata extract attenuates the L-Dopa-induced dyskinesis in Parkinson’s disease mouse model. Society for Neuroscience Abstract Viewer and Itinerary Planner 43, 2013

    Google Scholar 

  • Khan MR, Omoloso AD (2004) Antibacterial activity of Galeola foliata. Fitoterapia 75(5):494–496

    Article  CAS  PubMed  Google Scholar 

  • Kho MC, Lee YJ, Ahn YM et al (2013) Effect of ethanol extract of Gastrodia elata Blume on high-fructose induced metabolic syndrome. FASEB J 27:1108

    Google Scholar 

  • Kim HJ, Moon KD, Oh SY et al (2001) Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in mouse hippocampus. Neurosci Lett 314:65–68

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ, Lee SR, Moon KD (2003a) Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils. Phytother Res 17:909–912

    Article  PubMed  Google Scholar 

  • Kim HJ, Moon KD, Lee DS, Lee SH (2003b) Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptide-induced cell death. J Ethnopharmacol 84:95–98

    Article  PubMed  Google Scholar 

  • Kim ST, Kim JD, Lyu YS et al (2006) Neuroprotective effect of some plant extracts in cultured CT105-induced PC12 cells. Biol Pharm Bull 29:2021–2024

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ, Hwang IK, Won MH (2007) Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain Res 1181:130–141

    Article  CAS  PubMed  Google Scholar 

  • Kurzweil H, Lwin S (2014) A Guide to Orchids of Myanmar. Natural History Publications (Borneo), Kota Kinabalu

    Google Scholar 

  • Kusano S (1911) Gastrodia elata and its symbiotic association with Armillaria mellea, vol IV(I). College of Agriculture, Imperial University of Tokyo, Tokyo, pp 1–73

    Google Scholar 

  • Lang KY, Tsi ZH (1976) Orchidaceae. Iconographia Cormophytorum Sinicorum V. Science Press, Beijing

    Google Scholar 

  • Laschke MW, Vorsterman van Oijen AE, Scheuer C, Menger MD (2013) In-vitro and in-vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. Br J Pharmacol 163(4):835–844

    Article  CAS  Google Scholar 

  • Lawler LJ (1984) Ethnobotany of the orchidaceae. In: Arditti J (ed) Orchid biology reviews and perspectives, vol 3. Cornell University Press, Ithaca

    Google Scholar 

  • Lawler LJ, Slaytor M (1969) The distribution of alkaloids in orchids from the Territory of Papua New Guinea. Proc Linnean Soc NSW 94:419–421

    Google Scholar 

  • Lawler LJ, Slaytor M (1970a) Uses of Australian Orchids by Aborigines and Early Settlers. Med J Australia 2:1259–1261

    CAS  PubMed  Google Scholar 

  • Lawler LJ, Slaytor M (1970b) A simple method for screening plants for antibacterial activity. Aust J Pharmacy 51:609

    Google Scholar 

  • Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM (2009) Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 74:555–761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee KT, Kim BJ, Kim JH et al (1997) Biological screening of 100 plant extracts for cosmetic use (i) inhibitory activities of tyrosinase and DOPA auto-oxidation. Int J Cosmet Sci 19(6):291–298

    Article  CAS  PubMed  Google Scholar 

  • Lee YS, Ha JH, Yong CS et al (1999) Inhibitory effects of constituents of Gastrodia elata Bl. On glutamate-induced apoptosis in IMR-32 human neroblastoma cells. Arch Pharm Res 22:404–409

    Article  CAS  PubMed  Google Scholar 

  • Lee JY, Jang YW, Kang HS et al (2006) Ant-inflammatory action of phenolic compounds from Gastrodia elata root. Arch Pharm Res 29:849–858

    Article  CAS  PubMed  Google Scholar 

  • Lee YK, Woo MH, Kim CH et al (2007) Two new benzofurans from Gastrodia elata and their DNA topoisomerases I and II inhibitory activities. Planta Med 73(12):1287–1291

    Article  CAS  PubMed  Google Scholar 

  • Lee YJ, Hwang SM, Kang DG et al (2009) Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells. J Nat Med 63(4):463–467

    Article  PubMed  Google Scholar 

  • Li YM, Zhou ZL, Hong YF (1993a) Studies on the phenolic derivatives from Galeola faberi Rolfe. Yao Xue Xue Bao 28(10): 766–771

    Google Scholar 

  • Li HX, Ding MY, Yu JY (2001) Simultaneous determination of p- hydroxybenzyladehyde, p-hydroxybenzyl alcohol, 4(beta-D-glucopyranosyloxy)- benzyl alcohol, and sugars in Gastrodia elata Blume measured as their acetylated derivatives by GC-MS. J Chromatogr Sci 39:251–4

    Article  CAS  PubMed  Google Scholar 

  • Li HB, Chen F (2004) Preparative isolation and purification of gastrodin from the Chinese medicinal plant Gastrodia elata by high speed counter-current chromatography. J Chromatogr A 1052:229–232

    Article  CAS  PubMed  Google Scholar 

  • Li P, Li SP, Fu CM et al (2004) Pressurized solvent extraction in quality control of Chinese herb. Zhongguo Zhong Yao Za Zhi 29:723–726

    PubMed  Google Scholar 

  • Li N, Wang KJ, Chen JJ, Zhou J (2007) Phenolic compounds from the rhizomes of Gastrodia elata. J Asian Nat Prod Res 9:373–377

    Article  CAS  PubMed  Google Scholar 

  • Li M, Guo SX, Wang CL, Xiao PG (2009) Quantitaive determination of five glycosyloxybenzyl 2-isobutylmalates in the tubers of Gymadenia coinopsea and Coeloglossum viride var. bracteatum by HPLC. J Chromatogr Sci 47(8):709–713

    Article  CAS  PubMed  Google Scholar 

  • Li J, Kuang P, Liu RD et al (2013) Transfer of GAFP and NPI, two disease-resistant genes, into a Phalaenopsis by Agrobacterium tumefaciens. Pak J Bot 45(5):1761–1766

    Google Scholar 

  • Li SH, Chen WC, Lu KH et al (2014) Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive activity of Gastrodia elata Blume. J Agric Food Chem 63(43):10493–10503

    Google Scholar 

  • Li Z, Wang Y, Ouyang H et al (2015) J Chromatogr B Analyt Technol Biomed Life Sci 988:45–52

    Article  CAS  PubMed  Google Scholar 

  • Lin TP (1975) Native Orchids of Taiwan, vol 1. Southern Materials Center, Taipei

    Google Scholar 

  • Lin LC, Chen YF, Tsai TR, Tsai TH (2007) Analysis of brain distribution and billiary excretion of a nutrient supplement, gastrodin, in rat. Anal Chim Acta 590:173–9

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Mori A (1992) Antioxidant and free radical scavenging activities of Gastrodia elata Bl. and Uncaria rhynchophylla (Miq.) Jacks. Neuropharmacology 31(12):1287–1298

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Mori A (1993) Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA. Neuropharmacology 32:659–69

    Article  CAS  PubMed  Google Scholar 

  • Liu W, Hu YL, Wang M et al (2002) Purification, crystallization and preliminary X-ray diffraction analysis of a novel mannose-binding lectin from Gastrodia elata with antifungal properties. Acta Crystallogr D Biol Crystallogr 58:1833–1835

    Article  PubMed  CAS  Google Scholar 

  • Liu G, Dong Q, Yu F et al (2004) Identification of Gastrodia elata Blume by Fourier transform infrared spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi 24:308–310

    CAS  PubMed  Google Scholar 

  • Liu W, Yang N, Ding J et al (2005) Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin. J Biol Chem 280:14865–14876

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Tang X, Pei J et al (2006) Gastrodin interaction with human fibrinogen: anticoagulant effects and binding sites. Chemistry 12:7807–7815

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Yu ZB, Ye YH, Zhou YW (2008) Chemical constituents from the tubers of Cremastra appendiculata. Yao Xue Xue Bao 43(2):181–184

    CAS  PubMed  Google Scholar 

  • Lu H, Li AY, Liu FY et al (2009) Effects of gastrodin on the dopamine system of Tourette’s syndrome rat models. Biosci Trends 3:58–62

    CAS  Google Scholar 

  • Luning B (1964) Studies on the Orchidaceae alkaloids. I. Screening of species for alkaloids 1. Acta Chim Scand 18:1507–1516

    Article  CAS  Google Scholar 

  • Luning B (1967) Studies on Orchidaceae alkaloids IV. Screening of species for alkaloids 2. Phytochemistry 6:857–861

    Article  CAS  Google Scholar 

  • Luo HR (1985) Brief report on the planting of Gastrodia elata in the Dinghu Mountain area. Zhong Yao Tong Bao 10:8–10

    CAS  PubMed  Google Scholar 

  • Majumder PL, Bandyopadhyay D (2010) Stilbenoids and sequiterpene derivatives of the orchids Gastrochilum calceolaria and Dendrobium amoenum: application of 2D

    Google Scholar 

  • Manandhar NP, Manandhar S (2002) Plants and people of Nepal. Timber, Portland, OR

    Google Scholar 

  • Matsuda H, Morikawa T, Xie H, Yoshikawa M (2004) Antiallergic phenanthrenes and stilbenes from the tubers of Gymnadenia conopsea. Planta Med 70(9):847–855

    Article  CAS  PubMed  Google Scholar 

  • Matthew KM (1995) An excursion flora of Central Tamilnadu, India. A.A. Balkaema, Rotterdam, The Netherlands

    Google Scholar 

  • Mayr H (1998) Orchid names and their meanings. Gantner-Verlag K.G, Vaduz

    Google Scholar 

  • McCormick MK, Whigham DF, Sloan D et al (2006) Orchid-fungus fidelity: a marriage meant to last? Ecology 87(4):903–911

    Article  PubMed  Google Scholar 

  • Merkus FW, van den Berg MP (2007) Can nasal drug delivery bypass the blood-brain barrier? Questioning the direct transport theory. Drugs 8:133–144

    CAS  Google Scholar 

  • Mo L, Kang JC, He J et al (2009) A preliminary Study of the Composition of Endophytic Fungi from Gastrodia elata. J Fungal Res 6(4):211–215

    Google Scholar 

  • Mori A, Yokoi I, Noda Y, Willmore LJ (2004) Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies. Acta Med Okayama 58(3):111–118

    CAS  PubMed  Google Scholar 

  • Morikawa T, Xie H, Matsuda H et al (2006a) Bioactive constituents from Chinese natural medicines. XVII. Constituents with radical scavenging effect and new glucosyloxybenzyl 2-isobutylmalates from Gymnadenia conopsea. Chem Pharm Bull 54(4):506–513

    Article  CAS  PubMed  Google Scholar 

  • Morikawa T, Xie H, Matsuda H, Yoshikawa M (2006b) Glucosyloxybenzyl 2-isobutylmalates from the tubers of Gymnadenia conopsea. J Nat Prod 69(6):881–886

    Article  CAS  PubMed  Google Scholar 

  • Musharof Hossain M (2009) Traditional therapeutic uses of some indigenous orchids of Bangladesh. Med Aromat Plant Sci Biotechnol 3:100–106

    Google Scholar 

  • Muszyńska B, Sułkowska-Ziaja K, Wołkowska M, Ekiert H (2011) Chemical, pharmacological, and biological characterization of the culinary-medicinal honey mushroom, Armillaria mellea (Vahl) P. Kumm. (Agaricomycetideae): a review. Int J Med Mushrooms 13(2):167–175

    Article  PubMed  Google Scholar 

  • Nagel AK, Kalaariya H, Schnabel G (2010) Gastrodia Antifungal Protein (GAFP-1) and its transcript are absent from scions of chimeric transgenic-grafted plum. AGRIS 45(2):188–192

    Google Scholar 

  • Nah ELQ, Ng XW, Chen KS (2010) An in-vitro study of the effect of gastrodin on neuronal cells. Recent development in Chinese herbal medicine. Nanyang Technological University, 2010. Programs and Abstracts, p 67

    Google Scholar 

  • Nanakorn W, Watthana S (2008) Queen Sirikit Botanic Garden (Thai Native Orchids 1 and 2). Wanida Press, Chiang Mai

    Google Scholar 

  • Nayar TS, Koshy KC, Sathish Kumar C, Mohanan N, Mukunthakumar S (1986) Flora of Tropical Botanic Garden, Palode. TBGRI, Thiruvananthapuram

    Google Scholar 

  • Neal AP, Guilarte TR (2013) Mechanisms of lead and manganese toxicity. Toxicol Res (Camb) 2(2):99–114

    Article  CAS  Google Scholar 

  • Ng LT, Wu SJ, Tsai JY et al (2007) Antioxidant activities of cultured Armillaria mellea. Appl Biochem Microbiol 43(4):444–448

    Article  CAS  Google Scholar 

  • Niu Q, Niu P, He S (2004) Effect of Gastrodia elata on learning and memory impairment induced by aluminum in rats. Wei Sheng Yan Jiu 33:45–48

    PubMed  Google Scholar 

  • Ojemann LM, Nelson WL, Shin DS et al (2006) Tian ma, an ancient Chinese herb. offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav 8(2):376–383

    Article  PubMed  Google Scholar 

  • Ou JC, Hsieh WC, Lin IH, Chang YS, Chen IS (eds) (2003) The catalogue of medicinal plant resources in Taiwan. Department of Health, Executive Yuan, Taipei

    Google Scholar 

  • Pan R, Xu J (1998) Analysis gastrodin in various types of Gastrodia elata Bl. Zhongguo Zhong Yao Za Zhi 23:336–337

    CAS  PubMed  Google Scholar 

  • Pandey NK, Joshi GC, Mudaiya RK et al (2003) Management and conservation of medicinal orchids of Kumaon and Garhwal Himalaya. In: Singh V, Jain AP (eds) Ethnoboany and medicinal plants of India and Nepal. Scientific Publishers (India), Jodhpur, India, pp 114–118

    Google Scholar 

  • Pant B, Raskoti BB (2013) Medicinal orchids of Nepal. Himalayan Map House (P) Ltd, Kathmandu

    Google Scholar 

  • Paoletti P, Neyton J (2007) NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7(1):38–47

    Article  CAS  Google Scholar 

  • Park EJ, Lee WY (2013a) Quantitative effects of various tree species on tuber growth and pharmacological compositions of Gastrodia elata. Hort Environ Biotechnol 54(4):357–363

    Article  Google Scholar 

  • Park EJ, Lee WY (2013b) In vitro symbiotic germination of myco-heterotrophic Gastrodia elata by Mycena species. Plant Biotechnol Rep 7(2):185–191

    Article  CAS  Google Scholar 

  • Park EJ, Ahn JK, Lee WY, Kim ST (2008) Establishment of in-vitro production system of Gastrodia elata immature tubers followed by symbiotic seed germination. Plant Biol (Rockville) 2008:172–173

    Google Scholar 

  • Pearce NR, Cribb PJ (2002) The Orchids of Bhutan. Royal Botanic Garden, Edinburgh

    Google Scholar 

  • Peng CX, Gong JS, Zhang XF et al (2007) Production of gastrodin through biotransformation of p-hydroxybenzyl alcohol using hair root cultures of Datura tatula L. Afr J Biotechnol 7:211–216

    Google Scholar 

  • Perner H (2002) Orchids and eco-tourism: the world natural heritage and biosphere reserve, Huanglong. Proceedings of the 17th World Orchid Conference, Shah Alam, Malaysia, 158–164

    Google Scholar 

  • Perner H, Luo Y (2007) Orchids of Huanglong. Sichuan Fine Arts Publishing House, China

    Google Scholar 

  • Porter-Smith F, Stuart GA (2003) Chinese Medicinal Herbs: A Modern Edition of a Classic Sixteenth-Century Manual by Li Shih Chen. Dover Publications Inc., Mineola, NY

    Google Scholar 

  • Pyo MK, Jin JL, Koo YK, Yun-Choi HS (2004) Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects. Arch Pharm Res 27:381–385

    Article  CAS  PubMed  Google Scholar 

  • Qiu H, Tang W, Tong X et al (2007) Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti- dengue virus bioactivities. Carbohydr Res 342:2230–2236

    Article  CAS  PubMed  Google Scholar 

  • Ran YZ, Xu JT (1988) Studies on the inhibition of seed germination of Gastrodia elata Bl. by Armillaria mellea Qul. Zhong Yao Tong Bao 13:15–17

    CAS  PubMed  Google Scholar 

  • Ran Y, Xu J (1990) Selection of the germination strain of Mycena osmundicola Lange in Gastrodia elata Bl. seeds. Zhongguo Zhong Yao Za Zhi 15:271–274

    CAS  PubMed  Google Scholar 

  • Rao AN (2004) Medicinal Orchid Wealth of Arunachal Pradesh. Newsl ENVIS NODE Indian Med Plants 1(2):1–7

    CAS  Google Scholar 

  • Rao TA (2007) ETHNO BOTANICAL DATA ON WILD ORCHIDS OF MEDICINAL VALUE AS PRACTISED BY TRIBALS AT KUDREMUKH NATIONAL PARK IN KARNATAKA. Orchid Newsl 2(2):1–7

    Google Scholar 

  • Rao TA, Sridhar S (2007) Wild Orchids in Karnataka: a pictorial compendium. Institute of Natural Resources Conservation, Education, Research and Training (INCERT), Bangalore

    Google Scholar 

  • Rasmussen HN (1995) Terrestrial orchids from seed to mycotrophic plant. Cambridge University Press, Cambridge, UK

    Book  Google Scholar 

  • Reddy KN, Reddy CS, Raju VS (2005) Ethno-orchidology of orchids of Eastern Ghats of Andhra Pradesh. EPRTI Newsl 11(3)

    Google Scholar 

  • Remm K, Remm L (2009) Similarity-based large-scale distribution mapping of orchids. Biodivers Conserv 18(6):1629–1647

    Article  Google Scholar 

  • Ridley H (1894) The Orchidaceae and Apostasiaseae of the Malay Peninsula. J Linn Soc 32:335–338

    Google Scholar 

  • Rifai MA (1975) Extraordinary uses of orchids in Indonesia. Report First ASEAN Orchid Congress, Bangkok

    Google Scholar 

  • Riis BJ, Christensen C, Overgaard K (1986) The effect of nasal calcitonin on post-menopausal osteoporosis. In: Christensen C (ed) New horizons in Osteoporosis. Lancaster, Parthenon

    Google Scholar 

  • Rigmister JY (1988) Intranasal calcitonin: a new horizon in prevention of early post-menopausal bone loss. In: Christensen C (ed) New horizons in Osteoporosis. Lancaster, Parthenon

    Google Scholar 

  • Rong LH, Cai CT (2010) Effect of different woods on the yield of Gastrodia elata. Wuhan Zhiwuxue Yanjiu 28(6):761–766

    Google Scholar 

  • Sa Q, Wang Y, Li W (2003) The promoter of an antifungal protein gene from Gastrodia elata confers tissue-specific and fungus-inducible expression patterns and responds to both salicylic acid and jasmonic acid. Plant Cell Rep 22:79–84

    Article  CAS  PubMed  Google Scholar 

  • Sagarik R, Guy S (2011) Grammatophyllum speciosum. A gigantic specimen in flower and fruit. Orchids 80(12):730–733

    Google Scholar 

  • Sahakitpichan P, Mhidol C, Disadee W et al (2013) Glucopyranosyloxybenzyl derivatives of (R)-2-benzylmalic acid and (R)-eucomic acid, and an aromatic glucoside from the pseudobulbs of Grammatophyllum speciosum. Tetrahedron 69(3):1031–1037

    Article  CAS  Google Scholar 

  • Santapau H, Kapadia Z (1966) The Orchids of Bombay. Government of India Press, Calcutta

    Google Scholar 

  • Schachter SC (2009) Botanicals and Herbs: a traditional approach to treating epilepsy. Neurotherapeutics 6(2):415–420

    Article  PubMed  Google Scholar 

  • Schuiteman A, de Vogel EF (2000) Cac Ci Ho Lan (Orchidaceae) Cua Thai Lan, Lao, Campuchia Va Viet Nam. Orchid Genera of Thailand Laos, Cambodia and Vietnam. (Vietnamese-English edition). National Herbarium Nederland, Leiden

    Google Scholar 

  • Schultes RE, Pease AS (1963) Generic names of orchids. Their origin and meaning. Academic Press, New York

    Google Scholar 

  • Seidenfaden G, Wood JJ (1992) The Orchids of Peninsular Malaysia and Singapore. Olsen & Olsen, Fredensborg

    Google Scholar 

  • Sekizaki H, Kuninaga S, Yamamoto M (2008) Identification of Armillaria nabsnona in Gastrodia tubers. Biol Pharm Bull 31:1410–1414

    Article  CAS  PubMed  Google Scholar 

  • Seo BI, Joo SJ, Park JH et al (2010) The anti-osteoporotic effect of aqueous extracts of Gastrodiae Rhizoma in vitro and in vivo. J Health Sci 56(4):422–424

    Article  CAS  Google Scholar 

  • Seok YM, Jin FX, Shin HM et al (2011) HMCO5 attenuates vascular contraction through inhibition of RhoA/Rho-kinase pathway. J Ethnopharmcol 133(2):484–489

    Article  Google Scholar 

  • Shen D, Chang H (1963) The anticonvulsant and analgesic activities of Tian-Ma (Gastrodia elata Bl.). Acta Pharm Sin 10:242–245

    Google Scholar 

  • Shen-Hao Y, Wang D, Xiang-Lan M, Ying-Jun Z, Yang C-R (2008) The influencing factors on gastrodin content in the herbal materials of Gastrodia elata (Orchidaceae). Acta Bot Yunnanica 30(1):110–114

    Google Scholar 

  • Shi Y, Dong JW, Tang LN et al (2014) N-6-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice. Pharmcol Biochem Behav 126:146–151

    Article  CAS  Google Scholar 

  • Shin EJ, Whang WK, Kim SG et al (2010) Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor. J Pharm Sci 113(4):404–408

    Article  CAS  Google Scholar 

  • Shin EJ, Bach JH, Nguyen TT et al (2011) Gastrodia elata attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Curr Neuropharmacol 9(1):118–121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shuchang H, Qiao N, Piye N et al (2008) Protective effects of gastrodia elata on aluminium-chloride-induced learning impairments and alterations of amino acid neurotransmitter release in adult rats. Restor Neurol Neurosci 26:467–473

    PubMed  PubMed Central  Google Scholar 

  • Shyamala BN, Naidu MM et al (2007) Studies on the anti-oxidant activities of vanilla extract and its constituent compounds through in vitro models. J Agric Food Chem 55(19):7738–7743

    Article  CAS  PubMed  Google Scholar 

  • Strack D, Busch E, Klein E (1989) Anthocyanin patterns in European orchids and their taxonomic and phylogenetic relevance. Phytochemistry 28:2127–2139

    Article  CAS  Google Scholar 

  • Stuart GA (1911) Chinese Materia Medica: Vegetable Kingdom. (A revision of a work by F. Porter Smith.) American Presbyterian Mission Press, Shanghai

    Google Scholar 

  • Su H, Kang JC, Cao JJ et al (2014) Medicinal plant endophytes produce analogous bioactive compounds. Chiang Mai J Sci 41(1):1–13

    Google Scholar 

  • Su J, Wang B (1996) Quantitative method for the determination of contents of gastrodin in zhennaonin capsules. Zhongguo Zhong Yao Za Zhi 21:284–285

    CAS  PubMed  Google Scholar 

  • Sun XF, Wang W, Wang DQ, Du GY (2004) Research progress of neuroprotective mechanisms of Gastrodia elata and its preparation. Zhongguo Zhong Yao Za Zhi 29:292–295

    PubMed  Google Scholar 

  • Sun W, Miao B, Wang XC et al (2012) Gastrodin inhibits allodynia and hyperalgesis in painful diabetic retinopathy rats by decreasing excitability of nociceptive primary sensory neurons. PLoS One 7(6):e39647

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tang SL, Su HJ (1978) Flora of Taiwan, vol 5. Taiwan National University Press, Taipei

    Google Scholar 

  • Tao J, Fu TX, Luo Z et al (2006) Cloning of distinguishing DNA sequences of Gastrodia elata Bl. and application of them in identifying gastrodia tuber. Sheng Wu Gong Cheng Xue Bao 22:587–591

    CAS  PubMed  Google Scholar 

  • Tao J, Luo ZY, Msangi CI et al (2009) Relationships among genetic makeup, active ingredient content, and place of origin of the medicinal plant, gastrodia tuber. Biochem Genet 47:8–18

    Article  CAS  PubMed  Google Scholar 

  • Tasn DGH (2008) Grammotophyllum speciosum Bl. http://orchidaceaemalaysiana2.blogspot.com/2008/07/grammatophyllum-speciosum-bl_21html

  • Teo CC, Tan SN, Yong JWH et al (2008) Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodia elata Blume by pressurized hot water extraction and microwave-assisted extraction. J Chromatogr 1182:34–40

    Article  CAS  Google Scholar 

  • Thammasiri K (2010) Vitrification-based cryopreservation of Grammatophyllum speciosum protocorms. Cryoletters 31(4):347–357

    Google Scholar 

  • Trivedi VP, Dixit RS, Lal VK (1980) Orchids in the drug markets of Bareilly, Kanpur and nearby districts. Nagarjun (Calcutta) 23(8):157–163

    Google Scholar 

  • Tsai CF, Huang CL, Lin YL et al (2011) The neuroprotective effects of an extract of Gastrodia elata. J Ethnopharm 138(1):119–125

    Article  CAS  Google Scholar 

  • Tsai DS, Chang YS, Li TC, Peng WH (2014) Prescription pattern of Chinese herbal products for hypertension in Taiwan: a population-based study. J Ethnopharm 155(3):1534–1540

    Article  Google Scholar 

  • Vaddhanaphuti N (2001) A field guide to the wild orchids of Thailand, 3rd edn. Silkworm Books, Chiang Mai

    Google Scholar 

  • Vaddhanaphuti N (2005) A field guide to the wild orchids of Thailand, Fourth and Expanded Edition. Silkworm Books, Chiang Mai

    Google Scholar 

  • Veitch N, Grayer R (2003) 143. Goodyera. Phytochemistry. In: Pridgeon AM, Cribb PJ, Chase MW, Rasmussen FN (eds) Genera Orchidacearum, vol 3, Orchidoideae (Part 2) Vanilloideae. Oxford University Press, Oxford, p 97

    Google Scholar 

  • Venketasubramaniam N, Chen CL, Gan RN et al (2009) A double blind placebo-controlled, randomized, multicenter study to investigate Chinese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study). Int J Stroke 4(1):54–60

    Article  Google Scholar 

  • Vyas TK, Tiwan SB, Amiji MM (2006) Formulation and physiological factors influencing CNS delivery upon intranasal administration. Crit Rev Ther Drug Carrier Syst 23:319–347

    Article  CAS  PubMed  Google Scholar 

  • Wang ZB, Yan B (2010) Gastrodia elata Blume extract ameliorates exercise-induced fatigue. Afr J Biotechnol 9(36):5978–5982

    Google Scholar 

  • Wang YZ, Li JX, Wu QA et al (1989) Studies on the quality of Gastrodia elata Bl. cultivated with various kinds of fungus-growing materials. Zhongguo Zhong Yao Za Zhi 14:15–18

    CAS  PubMed  Google Scholar 

  • Wang X, Bauw G, Van Damme EJ et al (2001) Gastrodianin-like mannose-binding proteins: a novel class of plant proteins with antifungal properties. Plant J 25:651–661

    Article  CAS  PubMed  Google Scholar 

  • Wang D, Yang G, Li B et al (2002) Investigation of the chemico-physical characteristics of the active compounds in the Chinese herb Gastrodia elata Bl. by capillary zone electrophoresis. Anal Sci 18:409–412

    Article  CAS  PubMed  Google Scholar 

  • Wang DQ, Wang W, Sun XF et al (2005) Effect of Tianma gouteng recipe on interfering LV and aortic hypertrophy in renovascular hypertension rats. Zhongguo Zhong Yao Za Zhi 30(8):606–609

    PubMed  Google Scholar 

  • Wang HX, Yang T, Zeng Y, Hu Z (2007a) Expression analysis of the gastrodianin gene ga4B in an achlorophyllous plant Gastrodia elata Bl. Plant Cell Rep 26:253–259

    Article  PubMed  CAS  Google Scholar 

  • Wang J, Zeng JB, Zhao XF et al (2007b) Effects of Gymnadenia conopsea alcohol extract on collagen synthesis in rat lungs exposed to silica and its mechanism of antioxidative stress. Zhong Xi Yi Jie He Xue Bao 5(1):50–55

    Article  PubMed  Google Scholar 

  • Wang L, Xiao H, Liang X, Wei L (2007c) Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLC-UV-MS. J Sep Sci 30:1488–1495

    Article  CAS  PubMed  Google Scholar 

  • Wang Q, Chen G, Zeng S (2007d) Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v. Int J Pharm 341:20–25

    Article  CAS  PubMed  Google Scholar 

  • Wang SJ, Chen Y, He DD et al (2007e) Inhibition of smooth muscle cell proliferation by serum from rats treated orally with gastrodia and Uncaria decoction, a traditional Chinese formulation. J Ethnopharmacol 114:458–462

    Article  PubMed  Google Scholar 

  • Wang Q, Chen G, Zeng S (2008) Distribution and metabolism of gastrodin in rat brain. J Pharm Biomed Anal 46:399–404

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Lin S, Chen M (2012a) Y. Zhongguo Zhong Yao Za Zhi 37(12):1775–1781

    CAS  PubMed  Google Scholar 

  • Wang L, Xiao HB, Yang L, Wang ZT (2012b) Two new phenolic glycosides from the rhizome of Gastrodia elata. J Asian Nat Prod Res 14(5):457–462

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Wu Z, Liu X, Fu Q (2013a) Gastrodin ameliorates Parkinson’s disease by downregulating connexin 43. Mol Med Rep 8(2):585–590

    PubMed  Google Scholar 

  • Wang J, Feng B, Yang XC et al (2013b) Tianma Gouteng Yin as adjunctive treatment for essential hypertension and a systemic review of randomized clinical trials. Evid Based Complement Alternat Med 2013:706125

    PubMed  PubMed Central  Google Scholar 

  • Wen W (1979) China: a new medicine born of tradition. UNESCO Cour 7:25–27

    CAS  PubMed  Google Scholar 

  • Wong KC, Sun M (1999) Reproductive biology and conservation genetics of Goodyera procera (Orchidaceae). Am J Bot 86(10):1406–1413

    Article  CAS  PubMed  Google Scholar 

  • Wu XR (1994) A concise edition of medicinal plants in China. Guangdong Higher Education Publication House, Guangdong (in Chinese)

    Google Scholar 

  • Wu HQ, Xie L, Jin XN et al (1989) The effect of vanillin on the fully amygdala-kindled seizures in the rat. Yao Xue Xue Bao 24:482–486

    CAS  PubMed  Google Scholar 

  • Wu CR, Hsieh MT, Liao J (1996a) p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems. Clin J Physiol 39:265–273

    CAS  Google Scholar 

  • Wu CR, Hsieh MT, Huang SC et al (1996b) Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. Plant Med 62:317–321

    Article  CAS  Google Scholar 

  • Wu Y, Liu N, Long Q (1998) Effect of various nutrient solutions on quality of Gastrodia elata. Zhong Yao Cai 21:1–3

    CAS  PubMed  Google Scholar 

  • Wu TL, Hu QM, Xia NH, Lai PCC, Yip KL (2001) Check List of Hong Kong Plants 2001. Agriculture, Fisheries and Conservation Department Bulletin 1, Hongkong

    Google Scholar 

  • Wu TL, Hu QM, Xia NH, Lai PCC, Yip KL (2002) Check List of Hong Kong Plants 2001. Agriculture, Fisheries and Conservation Department Bulletin 1 (Revised), Hongkong

    Google Scholar 

  • Wu B, Liu M, Liu H (2007) Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke 38(6):1973–1979

    Article  PubMed  Google Scholar 

  • Wu H, Hu K, Jiang X (2008) From nose to brain: understanding transport capacity and transport rate of drugs. Expert Opin Drug Deliv 5:1159–1168

    Article  CAS  PubMed  Google Scholar 

  • Xiang J, Tang YP, Wu P et al (2010) Chinese medicine Nao-Shuan-Tong attenuates cerebral ischemic injury by inhibiting apoptosis in a rat model of stroke. J Ethnopharm 131(1):174–181

    Article  Google Scholar 

  • Xiao YQ, Li L, Yuo XL (2002a) Studies on chemical constituents of effective part of Gastrodia elata. Zhongguo Zhong Yao Za Zhi 27:35–36

    CAS  PubMed  Google Scholar 

  • Xiao YQ, Li L, You XL et al (2002b) A new compound from Gastrodia elata Blume. J Asian Nat Prod Res 4:73–79

    Article  CAS  PubMed  Google Scholar 

  • Xiao R, Tian Y, Liu L, Xu K (2009) Action of silky chicken-Gastrodia elata Blume nutrient solution on immunoregulatory function in mice. Wei Sheng Yan Jiu 38:283–286

    PubMed  Google Scholar 

  • Xiong J, Huang J (1998) The A1- and non A1-effects of N6-(5-hydroxy-2-pyridyl)- methyl-adenosine on rat vas deferens. Yao Xue Xue Bao 33(3):175–179

    CAS  PubMed  Google Scholar 

  • Xu JT (1989) Studies on the life cycle of Gastrodia elata. Zhongguo Yi Xi Xue Ke Xue Yuan Xue Bao 11:237–241

    CAS  Google Scholar 

  • Xu J (1990a) Cytological observation on hyphae invading Mycena osm undicola in the process of germination of Gastrodia elata Bl. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 12:313–317

    CAS  PubMed  Google Scholar 

  • Xu J (1990b) Studies on nutrition source of seeds germination of Gastrodia elata Bl. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 12:431–434

    CAS  PubMed  Google Scholar 

  • Xu JT (2001) The changes of cell structure in the courses of Armillaria mellea penetrating the nutritional stems of Gastrodia elata. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:150–153

    CAS  PubMed  Google Scholar 

  • Xu J, Guo S (2000) Retrospect on the research of the cultivation of gastrodia elata Bl, a rare traditional Chinese medicine. Chin Med J 113:686–692

    CAS  PubMed  Google Scholar 

  • Xu X, Lu Y, Bie X (2007) Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Med 73:650–654

    Article  CAS  PubMed  Google Scholar 

  • Yan Y, Chou GX, Dan M et al (2010) Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells. J Ethnopharm 129:387–390

    Article  CAS  Google Scholar 

  • Yang ZH, Zhang QT, Feng ZZ, Lang KY, Li H. English edition translated by ZR Xiong (1998) Orchids. China Esperanto Press, Beijing

    Google Scholar 

  • Yang XD, Zhu J, Yang R et al (2007) Phenolic constituents from the rhizomes of Gastrodia elata. Nat Prod Res 21:180–186

    Article  CAS  PubMed  Google Scholar 

  • Yang B, Li S, Zhang R et al (2009) Quantitative analysis of four active constituents in Tibetan herb Gymadenia conopsea by high-performance liquid chromatography. Zhongguo Zhong Yao Za Zhi 34(14):1819–1822

    CAS  PubMed  Google Scholar 

  • Yang YL, Wu KJ, Lu G (eds) (1999) Traditional Chinese Materia Medica. Wuhan University Press, Wuhan

    Google Scholar 

  • Yi ML, Zhou LZ, Yong FH (1993) New phenolic derivatives from Galeola faberi. Planta Med 59(4):363–365

    Article  Google Scholar 

  • Yong W, Xing TR, Wang S et al (2009) Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus. Planta Med 75:1112–1117

    Article  CAS  PubMed  Google Scholar 

  • You J, Tan T, Kuang A et al (1994) Biodistribution and metabolism of 3H-gastrodigenin and 3H-gastrodin in mice. Hua Xi Yi Ke Da Xue Xue Bao 25:325–328

    CAS  PubMed  Google Scholar 

  • Yu SJ, Kim JR, Lee CK et al (2005) Gastrodia elata Blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expression. Biol Pharm Bull 28:1016–1020

    Article  CAS  PubMed  Google Scholar 

  • Yue Z, Zi J, Zhu C et al (2010) Constituents of Gymnadenia conopsea. Zhongguo Zhong Yao Za Zhi 35(21):2852–2856

    CAS  PubMed  Google Scholar 

  • Yun-Choi HS, Pyo MK, Park KM (1998) Isolation of 3-0-(4’-hydroxybenzyl)-beta-sitosterol and 4-(4’-hydroxybenzyloxy)benzyloxy]benzyl methyl-ether from fresh tubers of Gastrodia elata. Arch Pharm Res 21:357–360

    Article  CAS  PubMed  Google Scholar 

  • Zeng X, Zhang S, Zhang L et al (2006) A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med 72L:1359–1365

    Article  CAS  Google Scholar 

  • Zeng XH, Zhang Y, Zhang SM, Zheng XX (2007) A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus. Biol Pharm Bull 30:801–804

    Article  CAS  PubMed  Google Scholar 

  • Zhang SH (2006) Gastrodin prevents cognitive decline related to cardiopulmonary bypass. Invitation to participate in a clinical trial (Clinical Trials.gov Identifier NCT00297245)

    Google Scholar 

  • Zhang CY, Du GY, Wang W et al (2004) Effects of tianma gouteng fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia. Zhongguo Zhong Yao Za Zhi 29(11):1061–1065

    PubMed  Google Scholar 

  • Zhang W, Sheng YX, Zhang JL et al (2007) Evaluation of the quality of Gastrodia elata by HPLC-DAD/MS. Yao Xue Xue Bao 42:418–423

    CAS  PubMed  Google Scholar 

  • Zhang W, Sheng YX, Zhang JL (2008) Determination and pharmacokinetics of gastrodin and p-hydroxynebzyl alcohol after oral administration of Gastrodia elata Blume. Extract in rats by high performance liquid chromatography-electrospray ionization mass spectrometric method. Phytomedicine 15:844–850

    Article  CAS  PubMed  Google Scholar 

  • Zhang Q, Yang YM, Yu YG (2008) Effects of gastrodin injection on blood pressure and vasoactive substances in treatment of old patients with refractory hypertension: a randomized controlled trial. Zhong Xi Yi Jie He Xue Bao 6:695–699

    Article  PubMed  Google Scholar 

  • Zhang YJ (2010) Gastrodia elata var obovata Yue J Zhang. Acta Bot Boreal -Occid Sin 30:1277

    Google Scholar 

  • Zhang Z, Ma P, Xu YN et al (2011) Preventive effect of gastrodin on cognitive decline after cardiac surgery with cardiopulmonary bypass: a double blind, randomized study. J Huazhong Univ Sci Tech (Med Sci) 31(1):120–127

    Article  CAS  Google Scholar 

  • Zhang HW, Tong J, Zhou G et al (2012) Tianma Gouteng Yin Formula in treating hypertension. Cochrane Database Syst Rev 6:CD008166. doi:10.1002/14651858CD008166.pub2

    PubMed  Google Scholar 

  • Zhang Y, Li M, Kang RX et al (2012b) NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects in sodium barbital treated mice. Pharm Biochem Behav 102(3):450–457

    Article  CAS  Google Scholar 

  • Zhang ZC, Su G, Li J et al (2013) Two new neuroprotective phenolic compounds from Gastrodia elata. J Asian Nat Prod Res 15(6):619–623

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Yu ZY, Wu XQ (2004) A new technique of extracting effective components from Chinese herb and natural plan-microwave assisted extraction. MAE Zhongguo Zhong Yao Za Zhi 29:104–108

    CAS  PubMed  Google Scholar 

  • Zhao YH, Liu YD, Guan Y, Liu NW (2010) Effect of Yinian Jiangya Yin on primary hypertension in early stage—a clinical observation on 40 patients. J Tradit Chin Med 30(3):171–175

    Article  PubMed  Google Scholar 

  • Zhonghua Bencao (2000) Edited by Health Department and National Chinese Medical Management Office. Science and Technology Press, Shanghai

    Google Scholar 

  • Zhonghua Bencao (2005) Edited by Health Department and National Chinese Medical Management Office. Science and Technology Press, Shanghai

    Google Scholar 

  • Zhongyao Da Cidian (1986) Edited by Jiangsu New Medical College. Science and Technology Press, Shanghai

    Google Scholar 

  • Zhou J (1991) Bioactive glycosides from Chinese medicines. Mem Inst Oswaldo Cruz 86(Suppl 2):231–234

    Article  PubMed  Google Scholar 

  • Zhou J, Yang YB, Yang CR (1979) The chemistry of Gastrodia elata Bl. 1. The isolation and identification of chemical compounds from Gastrodia elata Bl. Acta Chem Sin 37(3):183–189

    CAS  Google Scholar 

  • Zhou J, Yang YB, Yang CR (1980) Phenolic constituents of fresh Gastrodia elata Blume. Acta BotanicaYunnanica 2(3):370

    CAS  Google Scholar 

  • Zhou J, Pu XY, Yang YB (1982) Nine phenolic compounds of fresh Gastrodia elata Blume. Kexue Tongbao 27(2):179–181

    Google Scholar 

  • Zhu XX, Luo XG (2007) Optimization of extraction parameters and de-protein process for Gastrodia elata. Polysaccharides. Zhong Yao Cai 30:724–726

    CAS  PubMed  Google Scholar 

  • Zhu HL, Dai PG, Zhang W et al (2010) Enzymic synthesis of gastrodin through microbial transformation and purification of gastrodin biosynthesis enzyme. Biol Pharm Bull 33(10):1680–1684

    Article  CAS  PubMed  Google Scholar 

  • Zi JC, Lin S, Zhu CG et al (2010) Minor constituents from the tubers of Gymnadenia conopsea. J Asian Nat Prod Res 12(6):477–484

    Article  CAS  PubMed  Google Scholar 

  • Zou JN, Song JX, Chang CR, Wang XL (2006) RAPD analysis on the germplasm resources of Gastrodia elata in Guizhou. Zhong Yao Cai 29:881–883

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Teoh, E.S. (2016). Galeola to Gymadenia . In: Medicinal Orchids of Asia. Springer, Cham. https://doi.org/10.1007/978-3-319-24274-3_12

Download citation

Publish with us

Policies and ethics