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At the Forefront of the Suzuki–Miyaura Reaction: Advances in Stereoselective Cross-Couplings

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Synthesis and Application of Organoboron Compounds

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 49))

Abstract

The synthesis of optically enriched compounds is a continuing challenge in organic synthesis. While the Suzuki–Miyaura cross-coupling has been used extensively in the construction of sp2–sp2 bonds, only recently has it come to prominence as a useful means to construct stereogenic centres. This chapter describes the latest achievements in the development of stereoselective Suzuki–Miyaura cross-coupling reactions, including advances made both in atroposelective couplings as well as stereoselective C(sp3) couplings. Focus is also given to the mechanistic details of these cross-coupling processes.

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Authors and Affiliations

  1. Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB, T6G 2G2, Canada

    Ho-Yan Sun & Dennis G. Hall

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  1. Ho-Yan Sun
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  2. Dennis G. Hall
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Correspondence to Dennis G. Hall .

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Editors and Affiliations

  1. Universitat Rovira i Virgili Directora TECAT, Tarragona, Spain

    Elena Fernández

  2. Department of Chemistry, Centre for Sustainable Chemical Processes, Durham, United Kingdom

    Andrew Whiting

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Sun, HY., Hall, D.G. (2015). At the Forefront of the Suzuki–Miyaura Reaction: Advances in Stereoselective Cross-Couplings. In: Fernández, E., Whiting, A. (eds) Synthesis and Application of Organoboron Compounds. Topics in Organometallic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-319-13054-5_7

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