Abstract
Despite the significant progress being made in the field of liver surgery, intraoperative blood transfusion is still a significant risk in patients undergoing elective liver resection for benign tumors. In order to reduce the use of allogeneic blood, several pharmacological, anesthetic, and surgical interventions have been tried with variable success. A multidisciplinary approach aimed at minimizing blood transfusion requirements is necessary, which involve preoperative, intraoperative, and postoperative management of the patient.
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Pulitanò C, Arru M, Bellio L, Rossini S, Ferla G, Aldrighetti L (2007) A risk score for predicting perioperative blood transfusion in liver surgery. Br J Surg 94(7):860–865
Ibrahim S, Chen CL, Wang SH, Lin CC, Yang CH, Yong CC, Jawan B, Cheng YF (2007) Liver resection for benign liver tumors: indications and outcome. Am J Surg 193(1):5–9
Kamphues C, Engel S, Denecke T, Bova R, Hippler-Benscheidt M, Puhl G et al (2011) Safety of liver resection and effect on quality of life in patients with benign hepatic disease: single center experience. BMC Surg 11(1):16. doi:10.1186/1471-2482-11-16
Kooby DA, Stockman J, Ben-Porat L, Gonen M, Jarnagin WR, DeMatteo RP et al (2003) Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg 237(6):860–869. doi:10.1097/01.SLA.0000072371.95588.DA; discussion 869–870
Szczepiorkowski ZM, Dunbar NM (2013) Transfusion guidelines: when to transfuse. Hematology Am Soc Hematol Educ Program 2013:638–644. doi:10.1182/asheducation-2013.1.638
Thomas MJG, Gillon J, Desmond MJ (1996) Consensus conference on autologous transfusion. Preoperative autologous donation. Transfusion 36:633–639
van Klei WA, Rheineck Leyssius TA, Grobbee DE, Moons KGM (2002) Identifying patients for blood conservation strategies. Br J Surg 89:1176–1182
Melendez J, Arslan V, Fisher M, Wuest D, Jarnagin WR, Fong Y et al (1998) Perioperative outcome of major hepatic resections under low central venous pressure, anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction. J Am Coll Surg 187:620–625
Cockbain AJ, Masudi T, Lodge JPA, Toogood GJ, Prasad KR (2010) Predictors of blood transfusion requirement in elective liver resection. HPB 12(1):50–55. doi:10.1111/j.1477-2574.2009.00126.x
Kato K, Nomoto S, Sugimoto H, Kanazumi N, Takeda S, Nakao A (2009) Autologous blood storage before hepatectomy for hepatocellular carcinoma. Hepatogastroenterology 56:802–807
Lentschener C, Gomola A, Grabar S, Soubrane O, Dousset B, Massault PP, Penhoud C, Ozier Y (2004) The effect of erythropoietin on allogeneic blood requirement in patients undergoing elective liver resection: a model simulation. Anesth Analg 98(4):921–926
Gurusamy KS, Li J, Vaughan J, Sharma D, Davidson BR (2013) Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection. Cochrane Database Syst Rev 5, CD007338
Hasegawa K, Takayama T, Orii R, Sano K, Sugawara Y, Imamura H et al (2002) Effect of hypoventilation on bleeding during hepatic resection: a randomized controlled trial. Arch Surg 137(3):311–315
Matot I, Scheinin O, Jurim O, Eid A (2002) Effectiveness of acute normovolemic hemodilution to minimize allogeneic blood transfusion in major liver resections. Anesthesiology 97(4):794–800
Waters JH, Yazer M, Chen YF, Kloke J (2012) Blood salvage and cancer surgery: a meta-analysis of available studies. Transfusion 52:2167–2173
Schmidt A, Sues HC, Siegel E, Peetz D, Bengtsson A, Gervais HW (2009) Is cell salvage safe in liver resection? A pilot study. J Clin Anesth 21(8):579–584
Pulitanò C, Aldrighetti L, Arru M, Finazzi R, Catena M, Guzzetti E et al (2007) Preoperative methylprednisolone administration maintains coagulation homeostasis in patients undergoing liver resection: importance of inflammatory cytokine modulation. Shock (Augusta, Ga) 28(4):401–405. doi:10.1097/shk.0b013e318063ed11
Durila M, Malošek M (2014) Rotational thromboelastometry along with thromboelastography plays a critical role in the management of traumatic bleeding. Am J Emerg Med 32(3):288.e1–3
Gurusamy KS, Li J, Sharma D, Davidson BR (2009) Pharmacological interventions to decrease blood loss and blood transfusion requirements for liver resection. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD008085. doi: 10.1002/14651858.CD008085
Bezinover D, Kadry Z, Janicki P (2011) Contemporary anesthesia management for liver transplantation: a comparison of American and European methods. Middle East J Anesthesiol 21:251–258
Simillis C, Li T, Vaughan J, Becker LA, Davidson BR, Gurusamy KS (2014) Methods to decrease blood loss during liver resection: a network meta-analysis. Cochrane Database Syst Rev 4, CD010683
Wrighton LJ, O'Bosky KR, Namm JP, Senthil M (2012) Postoperative management after hepatic resection. J Gastrointest Oncol 3(1):41–47. doi:10.3978/j.issn. 2078-6891.2012.003
Torzilli G, Gambetti A, Del Fabbro D, Leoni P, Olivari N, Donadon M, Montorsi M, Makuuchi M (2004) Techniques for hepatectomies without blood transfusion, focusing on interpretation of postoperative anemia. Arch Surg 139(10):1061–1065
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Pulitanò, C. (2015). Blood and Transfusion Management in Liver Surgery. In: Aldrighetti, L., Cetta, F., Ferla, G. (eds) Benign Tumors of the Liver. Springer, Cham. https://doi.org/10.1007/978-3-319-12985-3_24
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DOI: https://doi.org/10.1007/978-3-319-12985-3_24
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