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Other Parenteral Anticoagulants

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Hemostasis and Thrombosis

Abstract

This chapter reviews other parenteral anticoagulants—danaparoid which is a heparin like one and the direct thrombin inhibitors. Although heparin and its derivatives are the most commonly used parenteral anticoagulants, other agents are also used for this purpose. Since clinical trials showed most of these had no major advantages over heparin, use of most of these agents is restricted to patients with heparin induced thrombocytopenia. The exception is bivalirudin which is also used in patients with acute coronary syndromes undergoing interventions.

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Suggested Reading

  • Boyce SW, Bandyk DF, Bartholomew JR, Frame JN, Rice L. A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study. Am J Ther. 2011;18(1):14–22.

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  • Curran MP. Bivalirudin: in patients with ST-segment elevation myocardial infarction. Drugs. 2010;70(7):909–18.

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  • Garcia DA, Baglin TP, Weitz JI, Samama MM; American College of Chest Physicians. Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e24S–43S.

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  • Kelton JG, Arnold DM, Bates SM. Nonheparin anticoagulants for heparin-induced thrombocytopenia. N Engl J Med. 2013;368(8): 737–44.

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Authors and Affiliations

  1. Pathology and Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA

    Thomas G. DeLoughery M.D., F.A.C.P., F.A.W.M. (Professor of Medicine)

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  1. Thomas G. DeLoughery M.D., F.A.C.P., F.A.W.M.
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Correspondence to Thomas G. DeLoughery M.D., F.A.C.P., F.A.W.M. .

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Editors and Affiliations

  1. Medicine, Pathology, and Pediatrics, Oregon Health & Science University, Portland, Oregon, USA

    Thomas G. DeLoughery

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© 2015 Springer International Publishing Switzerland

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DeLoughery, T.G. (2015). Other Parenteral Anticoagulants. In: DeLoughery, T. (eds) Hemostasis and Thrombosis. Springer, Cham. https://doi.org/10.1007/978-3-319-09312-3_23

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  • DOI: https://doi.org/10.1007/978-3-319-09312-3_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09311-6

  • Online ISBN: 978-3-319-09312-3

  • eBook Packages: MedicineMedicine (R0)

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