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Vaccines using Gene-Modified Tumor Cells

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Gene Therapy

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Abstract

To date, many cytokines and costimulatory molecules have been transfected in a number of different rodent tumors and in several cases, these gene modified tumor cells, when used as vaccines, induced tumor immunity leading to rejection of a challenge with the parental tumor (Blankenstein et al., 1996). Despite the limited success obtained previously in clinical trials involving tumor cell vaccines (Oettgen and Old, 1991), the recent molecular characterization of tumor associated antigens, the availability of many immunostimulatory molecules (i.e. cytokines) and improved methods for the transfer of genes in mammalian cells have revived the long-standing interest in immunotherapy.

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Authors
  1. S. Cayeux
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  2. Z. Qin
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  3. B. Dörken
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  4. T. Blankenstein
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Editors and Affiliations

  1. Max-Delbrück-Centrum für molekulare Medizin, Robert-Rössle-Strasse 10, D-13122, Berlin-Buch, Germany

    Thomas Blankenstein

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© 1999 Birkhäuser Verlag Basel

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Cayeux, S., Qin, Z., Dörken, B., Blankenstein, T. (1999). Vaccines using Gene-Modified Tumor Cells. In: Blankenstein, T. (eds) Gene Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7011-5_18

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  • DOI: https://doi.org/10.1007/978-3-0348-7011-5_18

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7013-9

  • Online ISBN: 978-3-0348-7011-5

  • eBook Packages: Springer Book Archive

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