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Effectors of Thermogenesis pp 229–245Cite as

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Role of Various Sites in Thermoregulatory Thermogenesis

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Part of the book series: Experientia Supplementum ((EXS,volume 32))

Abstract

The dominant concept during the past 100 years was that in adult mammals skeletal muscle is the site of thermoregulatory heat production. Observations suggesting thermoregulatory heat production by viscera [4, 24, 42] were largely disregarded: the debate centered on the existence of non-shivering thermogenesis (NST) by skeletal muscle. Ultimately NST by skeletal muscle was accepted after cold-induced thermogenesis had been demonstrated in the cold-adapted (C-A) curarized rat [8, 10, 13, 35] and in the denervated hind limb of the dog [9, 30].

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References

  1. Abramson, D.I., Kahn, A., Tuck, S. Jr., Turman, G.A., Reyal, H., Fleischer, C.J.: Relationship between a range of tissue temperature and local oxygen uptake in the human forearm. I. Changes observed under resting conditions. J. clin. Invest. 37 (1958), 1031–1038.

    Article  Google Scholar 

  2. Ashby, W.R.: Mathematical models and computer analysis of the function of the central nervous system. Ann. Rev. Physiol. 28 (1966), 89–106.

    Article  Google Scholar 

  3. Bartunková, R., Jansky, L.: Effect of cold and noradrenaline on the cardiovascular system of cold adapted rats. Physiol. bohemoslov. 20 (1971), 163–171.

    Google Scholar 

  4. Bernard, Cl.: Leçons sur la chaleur animale, sur les effets de la chaleur et sur la fièvre. Paris, Ballière 1876.

    Google Scholar 

  5. Brown, E., Mottram, R.F.: Effect of local cooling on glucose metabolism in the human forearm. J. Physiol. (Lond.) 152 (1960), 68-70 P.

    Google Scholar 

  6. Carmichael, E.A., Feldberg, W., Fleischhauer, K.: The site of origin of the tremor produced by tubocurarine acting from the cerebral ventricles. J. Physiol. (Lond.) 162 (1962), 539–554.

    Google Scholar 

  7. Clark, L.C. Jr., Misrahy, G., Fox, R.P.: Chronically implanted polarographic electrodes. J. Appl. Physiol. 13 (1958), 85–91.

    Google Scholar 

  8. Cottle, W.H., Carlson, L.D.: Regulation of heat production in cold-adapted rats. Proc. Soc. exp. Biol. Med. 92 (1956), 845–849.

    Article  Google Scholar 

  9. Davis, T.R.A.: Contribution of skeletal muscle to non-shivering thermogenesis in the dog. Amer. J. Physiol. 213 (1967), 1423–1426.

    Google Scholar 

  10. Davis, T.R.A., Johnston, D.R., Bell, F.C., Cremer, B.J.: Regulation of shivering and non shivering heat production during acclimation of rats. Amer. J. Physiol. 198 (1960), 471–475.

    Google Scholar 

  11. Dawkins, M.J.R., Hull, D.: Brown fat and the response of the new-born rabbit to cold. J. Physiol. (Lond.) 169 (1963), 101 P.

    Google Scholar 

  12. Dawkins, M.J.R., Scopes, J.W.: Non shivering thermogenesis and brown adipose tissue in the human new-born infant. Nature, 206 (1965), 201–202.

    Article  Google Scholar 

  13. Depocas, F.: The calorigenic response of cold-acclimated white rats to infused noradrenaline. Canad. J. Biochem. Physiol. 38 (1960), 107–114.

    Article  Google Scholar 

  14. Donhoffer, Sz., Sárdi, F., Szegvári, Gy.: Brown adipose tissue and thermoregulatory heat production in the rat. Nature, 203 (1964), 765–766.

    Article  Google Scholar 

  15. Donhoffer, Sz., Szegvári, Gy., Járai, I., Farkas, M.: Thermoregulatory heat production by the brain. Nature, 184 (1959), 993–994.

    Article  Google Scholar 

  16. Donhoffer Sz., Szegvári, Gy., Varga-Nagy, I., Járai, I.: Uber die Periodizität der chemischen Wärmeregulation der Ratte. Pflügers Arch. ges. Physiol. 265 (1957), 97–103.

    Article  Google Scholar 

  17. Donhoffer, Sz., Szegvári, Gy., Varga-Nagy, I., Járai, I.:Über die Lokalisation der erhöhten Wärmeproduktion bei der chemischen Wärmeregulation. Pflügers Arch. ges. Physiol. 265 (1957), 104–111.

    Article  Google Scholar 

  18. Donhoffer, Sz., Szegvári, Gy., Varga-Nagy, I., Járai, I., Háug-Laszló, Á.: Uber die Dynamik der chemischen Wärmeregulation der Ratte. Acta physiol. Acad. Sci. hung. 13 (1958), 37–56.

    Google Scholar 

  19. Dönhoffer, Sz., Szelényi, Z.: The role of brown adipose tissue in thermoregulatory heat production in the non-cold-adapted rat, guinea pig, ground squirrel, and young rabbit. Acta physiol. Acad. Sci. hung. 28 (1965), 349–361.

    Google Scholar 

  20. Donhoffer, Sz., Szelényi, Z.: The role of brown adipose tissue in thermoregulatory heat production in the warm-and cold-adapted rat. Acta physiol. Acad. Sci. hung. 32 (1967), 131–137.

    Google Scholar 

  21. Dubois, E.F., Edbough, F.G. Jr., Hardy, J.D.: Basal heat production and elimination of thirteen normal women at temperatures from 22 C to 35 C. J. Nutrit. 48 (1952), 257–293.

    Google Scholar 

  22. Durotoye, A., Alo. O., Ariwodola, O.: Effect of environmental cooling on gastrointestinal thermogenesis in anaesthetized dog. Life Sci. 19 (1976), 963–972.

    Article  Google Scholar 

  23. Edwards, M., Burton, A.C.: Temperature distribution over the human head, especially in the cold. J. Appl. Physiol. 15 (1960), 209–211.

    Google Scholar 

  24. Fedorov, N.A., Shur, E.I.: The role of viscera in regulating the temperature of the body of an animal under physiological and pathological conditions. Amer. J. Physiol. 137 (1942), 30–38.

    Google Scholar 

  25. Feldberg, W., Malcolm, J.L., Smith, I.D.: Effect of tubocurarine on the electrical activity of the cat’s brain under chloralose. J. Physiol. (Lond.) 138 (1957), 178–201.

    Google Scholar 

  26. Freeman, B.M.: Thermoregulatory mechanisms of the neonate fowl. Comp. Biochem. Physiol. 33 (1970), 219–230.

    Article  Google Scholar 

  27. Freeman, B.M.: Non-shivering thermogenesis in birds. In: Non-shivering thermogenesis, Ed. L. Jansky, Academia Prague, 1971, pp. 83-93.

    Google Scholar 

  28. Froese, G., Burton, A.C.: Heat losses from the human head. J. Appl. Physiol. 10 (1957), 235–245.

    Google Scholar 

  29. Heim, T., Hull, D.: Blood flow in brown adipose tissue. J. Physiol. (Lond.) 181 (1965), 60-61 P.

    Google Scholar 

  30. Issekutz, B. Jr., Hetényi, G. Jr., Nagy, H., Lung, M.: Temperature regulation of the denervated limb. Hung. Acta. physiol. 2 (1949), 93–104.

    Google Scholar 

  31. Jansky, L.: Total cytochrome oxidase activity and its relation to basal and maximal metabolism. Nature, 189 (1961), 921–922.

    Article  Google Scholar 

  32. Jansky, L.: Total cytochrome oxidase activity in cold-and warm-acclimated rats. Canad. J. Biochem. Physiol. 41 (1963), 1847–1854.

    Article  Google Scholar 

  33. Jansky, L.: Body organ thermogenesis of the rat during exposure to cold and at maximal metabolic rate. Fed. Proc. 25 (1966), 1297–1302.

    Google Scholar 

  34. Jansky, L.: Non-shivering thermogenesis and its thermoregulatory significance. Biol. Rev. Cambr. Philos. Soc. 48 (1973), 85–132.

    Article  Google Scholar 

  35. Jansky, L., Hart, J.S.: Participation of skeletal muscle and kidney during non-shivering thermogenesis in cold-acclimated rats. Canad. J. Biochem. Physiol. 41 (1963), 953–964.

    Article  Google Scholar 

  36. Jansky, L., Hart, J.S.: Cardiac output and organ blood flow in warm-and cold-acclimated rats exposed to cold. Canad. J. Biochem. Physiol. 46 (1968), 653–659.

    Google Scholar 

  37. Koméromi, I.: Effects of alpha-and beta-adrenergic blockers on the actions of noradrenaline on body temperature in the new-born guinea pig. Experientia, in the press.

    Google Scholar 

  38. LeBlanc, J.: Adaptation to cold in three hours. Amer. J. Physiol. 212 (1967), 530–532.

    Google Scholar 

  39. LeBlanc, J., Robinson, D., Sharman, D.F., Tousignant, P.: Catecholamines and short-term adaptation to cold in mice. Amer. J. Physiol. 213 (1967), 1419–1422.

    Google Scholar 

  40. McCook, R.D., Peiss, C.N., Randall, W.C.: Hypothalamic temperatures and blood flow. Proc. Soc. exp. Biol. Med. 109 (1962), 518–521.

    Article  Google Scholar 

  41. Nagasaka, T., Carlson, D.: Responses of cold-and warm-adapted dogs to infused noradrenaline and acute body cooling. Amer. J. Physiol. 209 (1965), 227–230.

    Google Scholar 

  42. Rein, H.: Vasomotorische Regulationen. Ergebn. Physiol. 32 (1931), 28–72.

    Article  Google Scholar 

  43. Rosenblith, W.A.: 1967, cit. McKay, D.M.: Neural communications: experiment and theory. Science, 159 (1968), 335–353.

    Article  Google Scholar 

  44. Smith, R.E.: Thermogenic activity of the hibernating gland in the cold acclimated rat. Physiologist, 4 (1961), 113.

    Google Scholar 

  45. Smith, R.E., Hock, R.J.: Brown fat: Thermogenic effector of arousal in hibernators. Science, 140 (1963), 199–200.

    Article  Google Scholar 

  46. Smith, R.W., Hoijer, D.J.: Metabolism and cellular function in cold acclimation. Physiol. Rev. 42 (1962) 60–142.

    Google Scholar 

  47. Stoner, B.: The role of liver in non-shivering thermogenesis in the rat. J. Physiol. (Lond.) 232 (1973), 285–296.

    Google Scholar 

  48. Szegvári, Gy., Várnai, I., Donhoffer, Sz.: The effect of environmental temperature, hypoxia, and hypercapnia on total heat production and the electrical activity of muscle in the rat. Shivering and non-shivering thermogenesis and the site of non-shivering heat production. Acta physiol. Acad. Sci. hung. 23 (1963), 49–62.

    Google Scholar 

  49. Székely, M., Kellermayer, M., Sümegi, I., Cholnoky, G.: Morphology and function of interscapular brown adipose tissue in the non-cold-adapted adult guinea pig. Acta physiol. Acad. Sci. hung. 38 (1970), 419–421.

    Google Scholar 

  50. Szelényi, Z.: Changes of oxygen tension (available oxygen, aO2) in rat brain during respiration of gas mixtures of different O2 and CO2 concentrations. Acta physiol. Acad. Sci. hung. 37 (1970), 65–71.

    Google Scholar 

  51. Szelényi, Z., Donhoffer, Sz.: The effect of cold exposure on pulsatile cerebral impedance and cerebral blood flow in the young rabbit. Acta physiol. Acad. Sci. hung. In the press.

    Google Scholar 

  52. Szelényi, Z., Donhoffer, Sz.: The effect of cold exposure on brain oxygen tension (available oxygen, aO2) in the rat and rabbit. Acta physiol. Acad. Sci. hung. In the press.

    Google Scholar 

  53. Szelényi, Z., Székely, M.: Pulsatile cerebral impedance: a method for monitoring changes in cerebral circulation. Acta physiol. Acad. Sci. hung. 45 (1974), 7–13.

    Google Scholar 

  54. Szelényi, Z., Székely, M., Donhoffer, Sz.: The effect of cold exposure on pulsatile cerebral impedance and cerebral blood flow in the rat. Acta physiol. Acad. Sci. hung. In the press.

    Google Scholar 

  55. Wekstein, D.R., Zolman, J.F.: Sympathetic control of homeothermy in the young chick. Amer. J. Physiol. 214 (1968), 918–921.

    Google Scholar 

  56. Wekstein, D.R., Zolman, J.F.: Ontogeny of heat production in chicks. Fed. Proc. 28 (1969), 123–128.

    Google Scholar 

  57. Wezler, K., Neuroth, G.: Die Koordinierung von physikalischer und chemischer Wärmeregulation. Zeitschr. ges. exp. Med. 115 (1949), 127–205.

    Article  Google Scholar 

  58. Wright, S.: Electroencephalographic patterns following intraventricular injection of tubocurarine in the cat. J. Physiol. (Lond.) 130 (1955), 35-36 P.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pathophysiology, University Medical School, Pécs, H-7643, Pécs, Szigeti út 12, Hungary

    Prof. Sz. Donhoffer

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  1. Department of Physiology, Medical School, Geneva, Switzerland

    L. Girardier  & J. Seydoux  & 

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© 1978 Springer Basel AG

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Donhoffer, S. (1978). Role of Various Sites in Thermoregulatory Thermogenesis. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_27

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  • DOI: https://doi.org/10.1007/978-3-0348-5559-4_27

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5561-7

  • Online ISBN: 978-3-0348-5559-4

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