Abstract
Laryngopharyngeal reflux is used to describe laryngeal irritation resulting from contact with gastric secretions. This condition usually presents with vague symptoms including globus (“lump-in-the-throat” sensation), throat clearing, voice alterations, cough, and sore throat. The anatomical structures involved include the larynx, esophagus, and stomach.
The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the US Government.
We are military service members. This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides that “Copyright protection under this title is not available for any work of the US Government.” Title 17 U.S.C. 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person’s official duties.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28. https://doi.org/10.1038/ajg.2012.444; published online 19 February 2013.
Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis. 1990;141:640–7.
el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755–60, ISSN 0016-5085.
Olson NR. Laryngopharyngeal manifestations of gastroesophageal reflux disease. Otolaryngol Clin N Am. 1991;24(5):1201–13. PubMed PMID: 1754220.
Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005;294(12):1534–40. https://doi.org/10.1001/jama.294.12.1534.
Klinkenberg-Knol EC. Otolaryngologic manifestations of gastro-oesophageal reflux disease. Scand J Gastroenterol Suppl. 1998;225:24–8. Review. PubMed PMID: 9515748.
Khan AM, Hashmi SR, Elahi F, Tariq M, Ingrams DR. Laryngopharyngeal reflux: a literature review. Surgeon. 2006;4(4):221–5. Review. PubMed PMID: 16892839.
Modlin IM, Moss SF, Kidd M, Lye KD. Gastroesophageal reflux disease: then and now. J Clin Gastroenterol. 2004;38(5):390–402. Review. PubMed PMID: 15100517.
Stephen J, Sontag MD. Gastroesophageal reflux and asthma. Am J Med. 1997;103(5, Suppl 1):84S–90S, ISSN 0002-9343.
Bray GW. The treatment of asthma. Postgrad Med J. 1935;11(120):339–45.
PubMed PMID: 21312974; PubMed Central PMCID: PMC2476505.
Winkelstein A. Peptic esophagitis. J Am Med Assoc. 1935;104(11):906–9.
Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope. 1968;78(11):1937–40.
Malcomson KG. Radiological findings in globus hystericus. Br J Radiol. 1966;39(464):583–6.
Lee BE, Kim GH. Globus pharyngeus: a review of its etiology, diagnosis and treatment. World J Gastroenterol: WJG. 2012;18(20):2462–71. https://doi.org/10.3748/wjg.v18.i20.2462.
Malcomson K. Globus hystericus vel pharyngis: a reconnaissance of proximal vagal modalities. J Laryngol Otol. 1968;82(3):219–30. https://doi.org/10.1017/S0022215100068687.
Delahunty JE, Cherry J. Experimentally produced vocal cord granulomas. Laryngoscope. 1968;78(11):1941–7. PubMed PMID: 5722897.
Little FB, Koufman JA, Kohut RI, Marshall RB. Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol. 1985;94(5 Pt 1):516–9. PubMed PMID: 4051410.
Adhami T, Goldblum JR, Richter JE, Vaezi MF. The role of gastric and duodenal agents in laryngeal injury: an experimental canine model. Am J Gastroenterol. 2004;99(11):2098–106. PubMed PMID: 15554987.
Johnson LF, Demeester TR. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol. 1974;62(4):325–32. PubMed PMID: 4432845.
Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol. 1989;84(12):1503–8. PubMed PMID: 2596451.
DeMeester TR, Bonavina L, Iascone C, Courtney JV, Skinner DB. Chronic respiratory symptoms and occult gastroesophageal reflux. A prospective clinical study and results of surgical therapy. Ann Surg. 1990;211(3):337–45. PubMed PMID: 2310240; PubMed Central PMCID: PMC1358440.
Kamel PL, Hanson D, Kahrilas PJ. Omeprazole for the treatment of posterior laryngitis. Am J Med. 1994;96(4):321–6, ISSN 0002-9343. https://doi.org/10.1016/0002-9343(94)90061-2.
Little JP, Matthews BL, Glock MS, Koufman JA, Reboussin DM, Loughlin CJ, McGuirt WF Jr. Extraesophageal pediatric reflux: 24-hour double-probe pH monitoring of 222 children. Ann Otol Rhinol Laryngol Suppl. 1997;169:1–16. PubMed PMID: 9228867.
Hawkins BL. Laryngopharyngeal reflux: a modern day “great masquerader”. J Ky Med Assoc. 1997;95(9):379–85. Review. PubMed PMID: 9322411
Koufman J, Sataloff RT, Toohill R. Laryngopharyngeal reflux: consensus conference report. J Voice. 1996;10(3):215–6. PubMed PMID: 8865091.
Johnson J. Bailey’s head and neck surgery: otolaryngology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2013.
Marieb EN, Hoehn K. Human anatomy & physiology. San Francisco: Benjamin Cummings; 2010. ISBN 0-8053-9591-1.
Czinn SJ, Blanchard SS. 25 – developmental anatomy and physiology of the stomach. In: Wyllie R, Hyams JS, editors. Pediatric gastrointestinal and liver disease (fourth edition). Saint Louis: W.B. Saunders; 2011. p. 262–268.e1. https://doi.org/10.1016/B978-1-4377-0774-8.10025-9. ISBN 9781437707748.
Samloff IM. Peptic ulcer: the many proteinases of aggression. Gastroenterology. 1989;96(2 Pt 2 Suppl):586–95. Review. PubMed PMID: 2642445.
Lu W, Liu X, Liu Y-l, Zeng F-f, Wu T, Yang C-l, Shen H-y, Li X-p. Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs. Otolaryngol Head Neck Surg. 2010;143(6):765–71, ISSN 0194-5998.
Park D, Lee HH, Lee ST, Oh Y, Lee JC, Nam KW, Ryu JS. Normal contractile algorithm of swallowing related muscles revealed by needle EMG and its comparison to videofluoroscopic swallowing study and high resolution manometry studies: a preliminary study. J Electromyogr Kinesiol. 2017;36:81–9. https://doi.org/10.1016/j.jelekin.2017.07.007. [Epub ahead of print] PubMed PMID: 28763682.
Kahrilas PJ, Dodds WJ, Dent J, Haeberle B, Hogan WJ, Arndorfer RC. Effect of sleep, spontaneous gastroesophageal reflux, and a meal on upper esophageal sphincter pressure in normal human volunteers. Gastroenterology. 1987;92(2):466–71, ISSN 0016-5085.
Naito Y, Uchiyama K, Kuroda M, Takagi T, Kokura S, Yoshida N, Ichikawa H, Yoshikawa T. Role of pancreatic trypsin in chronic esophagitis induced bygastroduodenal reflux in rats. J Gastroenterol. 2006;41(3):198–208. PubMedPMID: 16699853.
Fitzgerald RC, Onwuegbusi BA, Bajaj-Elliott M, Saeed IT, Burnham WR, Farthing MJ. Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut. 2002;50(4):451–9. PubMed PMID: 11889061; PubMed Central PMCID: PMC1773186.
Sasaki CT, Marotta J, Hundal J, Chow J, Eisen RN. Bile-induced laryngitis: is there a basis in evidence? Ann Otol Rhinol Laryngol. 2005;114(3):192–7. PubMed PMID: 15825567.
Cobeta I, Pacheco A, Mora E. The role of the larynx in chronic cough. Acta Otorrinolaringol Esp. 2013;64:363.
Bucca CB, Bugiani M, Culla B, et al. Chronic cough and irritable larynx. J Allergy Clin Immunol. 2011;127:412.
Cook IJ, Dent J, Shannon S, Collins SM. Measurement of upper esophageal sphincter pressure. Effect of acute emotional stress. Gastroenterology. 1987;93(3):526–32. PubMed PMID: 3609662.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Morrison, M.P., Anderson, D.C. (2019). Laryngopharyngeal Reflux. In: Jamal, N., Wang, M. (eds) Laryngopharyngeal Reflux Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-12318-5_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-12318-5_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-12317-8
Online ISBN: 978-3-030-12318-5
eBook Packages: MedicineMedicine (R0)