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Handbook of Polymer and Ceramic Nanotechnology pp 1–22Cite as

Iron Oxide-Based Polymeric Magnetic Nanoparticles for Drug and Gene Delivery: In Vitro and In Vivo Applications in Cancer

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Abstract

In the war against cancer, nanotechnology has important role by improving the efficacy of traditional therapies. Nanoparticle-based drug delivery system has many advantages including imaging, drug delivery, extended circulation time, and controlled release. In recent years, iron oxide-based polymeric magnetic nanoparticles have gained significance in biomedical applications due to their superparamagnetism, high surface area, low toxicity, and easy separation in the presence of magnetic fields. Numerous methods have been developed for the production of iron oxide-based polymeric magnetic nanoparticles of different shapes and sizes, including hydrothermal, coprecipitation, thermal decomposition electrochemical, biological synthesis, etc. The nanoscale size, large surface area, and unique properties of iron oxide-based polymeric magnetic nanoparticles make them highly efficient in the diagnosis and treatment of such ailments as cancer, neurodegenerative disorders, and cardiovascular disease. This chapter investigates the design, synthesis, characterization, and in vivo/in vitro application of iron oxide-based polymeric magnetic nanoparticles in the treatment of cancer, as well as recent progress and perspectives in the field.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Kırsehir Ahi Evran University, Kırsehir, Turkey

    Serap Yalcin

  2. Department of Biology, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey

    Ufuk Gündüz

Authors
  1. Serap Yalcin
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  2. Ufuk Gündüz
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Correspondence to Serap Yalcin .

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Editors and Affiliations

  1. Dept. of Chemistry and EVSC, New Jersey InstTech, 151 D Tiernan-NJIT, Newark, NJ, USA

    Chaudhery Mustansar Hussain

  2. Centre for Nanoscience & Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India

    Sabu Thomas

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Yalcin, S., Gündüz, U. (2019). Iron Oxide-Based Polymeric Magnetic Nanoparticles for Drug and Gene Delivery: In Vitro and In Vivo Applications in Cancer. In: Hussain, C., Thomas, S. (eds) Handbook of Polymer and Ceramic Nanotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-10614-0_38-1

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  • DOI: https://doi.org/10.1007/978-3-030-10614-0_38-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10614-0

  • Online ISBN: 978-3-030-10614-0

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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