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HO-1/HSP32 and Cardiac Stress Signaling

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Heat Shock Proteins in Signaling Pathways

Part of the book series: Heat Shock Proteins ((HESP,volume 17))

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Abstract

In recent years, increased attention has been gained in elucidating the therapeutic potential of heme oxygenase-1 (HO-1), a rate limiting enzyme involved in the heme metabolism and their pathophysiology of various cardiovascular diseases and heart failure models. HO-1 exhibits multi-faceted role in the systemic regulation of redox, energy homeostasis and boosts the survival and vascular function in various cardiomyopathies. Induction of HO-1 has been known to modulate vascular cell proliferation, inflammation, endothelialization, oxidative damages, apoptosis, fibrosis, ischemic/perfusion injuries, neovascularization and prevent atherosclerotic lesion formation in the pathophysiology of experimental cardiomyopathies. The present chapter summarizes the cardioprotective mechanism of HO-1 and their molecular regulations, potential interaction/cross talk with myocardial cell survival and death signaling cascade. This chapter further reveals the genetic ablation of HO-1, overexpression of transgenic mutants and ascertains the role of HO-1 in cardiac stem cell therapy and xenograft survival in ischemic hearts. Eventually, we examined the pharmacological modulators of HO-1 from the natural and dietary therapeutic polyphenols and their mode of cardioprotection in both in vivo and in vitro models. In this context, the present chapter will append the existing knowledge of HO-1 and their regulation in the cardiac stress signaling cascades.

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Abbreviations

AP-1:

activator protein-1

AP-2:

activator protein-2

Bach1:

broad-complex, tramtrack and bric-a-brac and cap’n’collar homology 1

CAM:

cell adhesion molecule

CaMKKb:

Ca2+/calmodulin-dependent protein kinase

CO:

carbon monoxide

CREB1:

cAMP response element-binding protein 1

CTGF:

connective tissue growth factor

DCM:

diabetic cardiomyopathy

EBP:

emopamil-binding protein

ER:

endoplasmic reticulum

HO-1:

heme oxygenase-1

Hsp32:

heat shock protein 32

ICAM1:

intracellular adhesion molecule 1

IL:

interleukin

MAPK:

mitogen activated protein kinase

NF-κB:

nuclear factor-κB

Nrf2:

nuclear factor erythroid 2-related factor 2

PKC1:

protein kinase C1

SDF:

stromal cell-derived factor

SER:

smooth endoplasmic reticulum

STATx:

signal transducers and activators of transcription x

TNF-α:

tumor necrosis factor-α

VCAM1:

vascular cell adhesion molecule 1

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Acknowledgements

Azhwar Raghunath is the recipient of a University Grants Commission – Basic Scientific Research Senior Research Fellowship (UGC-BSR-SRF – No.F.7-25/2007) funded by UGC-BSR, New Delhi, India. We thank the Department of Science and Technology, Science and Engineering Board (EMR/2014/000600), and Empowerment and Equity Opportunities for Excellence in Science (SB/EMEQ-246/2014), New Delhi, for financial assistance. This work was also supported by the University Grants Commission – Special Assistance Programme (UGC-SAP-II:F-3-20/2013) and Department of Science and Technology, Fund for Improvement of Science and Technology infrastructure in universities and higher educational institutions (DST-FIST:SR/FST/LSI-618/2014), New Delhi, India.

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  1. Authors Lakshmikanthan Panneerselvam, Azhwar Raghunath and Kiruthika Sundarraj have been equally contributed to this chapter.

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  1. Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India

    Lakshmikanthan Panneerselvam, Azhwar Raghunath, Kiruthika Sundarraj & Ekambaram Perumal

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  1. Professor, Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Panneerselvam, L., Raghunath, A., Sundarraj, K., Perumal, E. (2019). HO-1/HSP32 and Cardiac Stress Signaling. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-030-03952-3_8

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