Abstract
Skeletal muscle comprises approximately 40% of the total body mass in humans. It plays important roles in locomotion, metabolism and endocrine signaling. We and others have previously described the biological responses/adaptations of skeletal muscle to heat stress, the contributions of heat shock proteins to the cellular processes underlying the muscle response to heat stress, and the therapeutic potential of manipulating heat stress and heat shock proteins in skeletal muscle. In this chapter, I briefly summarize current understanding of the heat stress-induced regulation of protein, glucose and mitochondrial metabolism in skeletal muscle. Furthermore, I overview future perspectives on studies of the heat shock response in skeletal muscle biology.
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Abbreviations
- AMPK:
-
AMP-activated protein kinase
- BGP-15:
-
O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime
- CaMKII:
-
Ca2+/calmodulin-dependent protein kinase II
- DEPTORDEP:
-
domain-containing mTOR-interacting protein
- FOXO:
-
forkhead box O
- GLUT:
-
glucose transporter
- HSE:
-
heat shock element
- HSF1:
-
heat shock factor 1
- HSP:
-
heat shock protein
- IGF-1:
-
insulin-like growth factor 1
- JNK:
-
c-Jun N-terminal kinases
- LC3:
-
microtubule-associated proteins 1A/1B light chain 3
- MAPK:
-
mitogen-activated protein kinase
- MFN2:
-
mitofusion 2
- MLST8:
-
MTOR associated protein
- mTOR:
-
mechanistic target of rapamycin
- NRF:
-
nuclear respiratory factor
- PGC-1α:
-
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- PP2A:
-
protein phosphatase 2
- PPAR:
-
peroxisome proliferator-activated receptor
- PRAS:
-
proline-rich Akt substrate
- RAPTOR:
-
regulatory-associated protein
- ROS:
-
reactive oxygen species
- UPR:
-
unfolded protein response
- VDAC:
-
voltage-dependent anion channels
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Acknowledgements
Yuki Tamura is the recipient of a post-doctoral fellowship from the Japan Society for the Promotion of Science, Tokyo, Japan.
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Tamura, Y. (2019). Heat Shock Response and Metabolism in Skeletal Muscle. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-030-03952-3_3
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DOI: https://doi.org/10.1007/978-3-030-03952-3_3
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