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Heat Shock Proteins in Neural Signaling: Implications in Health and Disease

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Heat Shock Proteins in Signaling Pathways

Part of the book series: Heat Shock Proteins ((HESP,volume 17))

Abstract

Much of the recent work has given insights into the non-canonical roles of heat shock proteins, strongly indicating a potential avenue for exploring the contribution of these proteins towards the normal physiology as well as various pathological conditions apart from hyperthermia-related stress. In this chapter, the role of intracellular as well as extracellular heat shock proteins in regulating various cellular signalling pathways has been discussed, with an emphasis on the biochemical and functional aspects of signalling in the central nervous system throughout various developmental stages. Further, their influence in regulating various pathological pathways including apoptosis and immune responses has been highlighted concerning different acute and chronic neurological disorders. Finally, the possibility of heat shock proteins as potential neuroprotective targets and the clinical relevance of their intracellular as well as extracellular forms has been explored.

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Abbreviations

AIF:

apoptosis-inducing factor

Akt:

protein kinase B

APCs:

antigen presenting cells

CNS:

central nervous system

CTL:

cytotoxic T lymphocytes

eHSP:

extracellular/exogenous HSP

Hsc:

constitutive isoform of Hsp

Hsf1:

heat shock factor1

Hsp:

heat shock protein

HSP:

heat shock protein family

IKK:

IκB kinase

IL:

interleukin

JNK:

c-Jun N-terminal kinase

MAPK:

mitogen-activated protein kinase

MHC:

major histocompatibility complex

NFκB:

nuclear factor kappa-light-chain-enhancer of activated B cells

PrPC:

cellular prion protein

ROS:

reactive oxygen species

STI1:

stress-inducible protein 1

TGFβ:

tumor growth factor beta

TLRs:

toll-like receptors

TNFα:

tumor necrosis factor alpha

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Acknowledgements

The authors thank CERVO Brain Research Institute, Quebec city (Canada) and Department of Biotechnology, TERI School of Advanced Studies, New Delhi (India).

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  1. Centre de Recherche CERVO, Quebec City, QC, Canada

    Pooja-Shree Mishra

  2. Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India

    Aditi Singh

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Correspondence to Pooja-Shree Mishra .

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  1. Professor, Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Mishra, PS., Singh, A. (2019). Heat Shock Proteins in Neural Signaling: Implications in Health and Disease. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-030-03952-3_22

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