Abstract
The present chapter is aimed towards giving an overview of the applications of keratin as a potential biomaterial substitute in the field of biotechnology. Keratin is a fibrous protein and considered as biomaterial due to its biocompatible and biodegradable characteristics. Its use as biopolymer has been the subject of intense investigation over the past few years. Wool, feather, horn and hooves, etc., are strong in terms of mechanical strength due to the presence of keratin. But once keratin is extracted from natural sources then, it becomes poor in mechanical properties. So, the blending of keratin with other biopolymer can improve the material properties like strength, flexibility, and water vapor permeability. The malleable nature of keratin proves its biotechnological applications such as tissue engineering scaffold, green composites, green cement, bioplastic, etc. The functional groups and chemical structures of keratin govern its properties and morphology, which gives an opportunity to control the design of desired molecular structure for various applications, and varies from industrial to the biotechnological field. Recently, the biodegradable keratin-based biopolymers have gained considerable importance in the medical field as they avoid additional surgery to remove the implants and lack of medical waste burden. Thus, much attention needs to be undertaken on the development of composite biomaterial derived from keratin.
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References
Abukawa H, Papadaki M, Abulikemu M et al (2006) The engineering of craniofacial tissues in the laboratory: a review of biomaterials for scaffolds and implant coatings. Dent Clin North Am 50:205–216, viii. https://doi.org/10.1016/j.cden.2005.11.006
Ahmed S, Ikram S (2016) Chitosan based scaffolds and their applications in wound healing. Achiev Life Sci. https://doi.org/10.1016/j.als.2016.04.001
Akita S, Akino K, Hirano A (2013) Basic fibroblast growth factor in scarless wound healing. Adv Wound Care 2:44–49. https://doi.org/10.1089/wound.2011.0324
An J, Teoh JEM, Suntornnond R, Chua CK (2015) Design and 3D printing of scaffolds and tissues. Engineering 1:261–268. https://doi.org/10.15302/j-eng-2015061
An T, Zhang C, Han X et al (2016) Hyaluronic acid-coated poly(β-amino) ester nanoparticles as carrier of doxorubicin for overcoming drug resistance in breast cancer cells. RSC Adv 6:38624–38636. https://doi.org/10.1039/c6ra03997a
Arslan YE, Sezgin Arslan T, Derkus B et al (2017) Fabrication of human hair keratin/jellyfish collagen/eggshell-derived hydroxyapatite osteoinductive biocomposite scaffolds for bone tissue engineering: from waste to regenerative medicine products. Colloids SurfS B Biointerfaces 154:160–170. https://doi.org/10.1016/j.colsurfb.2017.03.034
Augst AD, Kong HJ, Mooney DJ (2006) Alginate hydrogels as biomaterials. Macromol Biosci 6:623–633. https://doi.org/10.1002/mabi.200600069
Badylak SF (2002) The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol 13:377–383
Bainbridge P (2013) Keratin nanofibers as a biomaterial. J Wound Care 22:407–412. https://doi.org/10.12968/jowc.2013.22.8.407
Balaji S, Kumar R, Sripriya R et al (2012) Preparation and comparative characterization of keratin–chitosan and keratin–gelatin composite scaffolds for tissue engineering applications. Mater Sci Eng, C 32:975–982. https://doi.org/10.1016/j.msec.2012.02.023
Bandyopadhyay A, Bose S (2013) Characterization of biomaterials, 1st edn. Elsevier, The Netherlands
Barone JR, Schmidt WF (2005) Polyethylene reinforced with keratin fibers obtained from chicken feathers. Compos Sci Technol 65:173–181
Barone JR, Schmidt WF, Liebner CFE (2005) Thermally processed keratin films. J Appl Polym Sci 97:1644–1651. https://doi.org/10.1002/app.21901
Belverud S, Mogilner A, Schulder M (2008) Intrathecal pumps. Neurotherapeutics 5:114–122. https://doi.org/10.1016/j.nurt.2007.10.070
Berglund JD, Mohseni MM, Nerem RM, Sambanis A (2003) A biological hybrid model for collagen-based tissue engineered vascular constructs. Biomaterials 24:1241–1254. https://doi.org/10.1016/s0142-9612(02)00506-9
Bertini F, Canetti M, Patrucco A, Zoccola M (2013) Wool keratin–polypropylene composites: properties and thermal degradation. Polym Degrad Stab 98:980–987
Bhardwaj N, Kundu SC (2011) Silk fibroin protein and chitosan polyelectrolyte complex porous scaffolds for tissue engineering applications. Carbohydr Polym 85:325–333
Bhardwaj N, Sow WT, Devi D et al (2015) Silk fibroin–keratin based 3D scaffolds as a dermal substitute for skin tissue engineering. Integr Biol (Camb) 7:53–63. https://doi.org/10.1039/c4ib00208c
Blakytny R, Jude E (2006) The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 23:594–608. https://doi.org/10.1111/j.1464-5491.2006.01773.x
Boateng JS, Matthews KH, Stevens HNE, Eccleston GM (2008) Wound healing dressings and drug delivery systems: a review. J Pharm Sci 97:2829–2923. https://doi.org/10.1002/jps
Bourtoom T (2009) Edible protein films: properties enhancement. Int Food Res J 16:1–9
Bowler PG, Duerden BI, Armstrong DG (2001) Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 14:244–269. https://doi.org/10.1128/cmr.14.2.244-269.2001
Brandenburg AH, Weller CL, Testin RF (1993) Edible films and coatings from soy protein. J Food Sci 58:1086–1089
Bullions TA, Hoffman D, Price-O’Brien J, Loos AC (2003) Feather fiber/cellulose fiber/polypropylene composites manufactured via the wetlay papermaking process. In: International Nonwovens Technical Conference (INTC 2003), Balt, MD, USA
Bullions TA, Gillespie RA, Price-O’Brien J, Loos AC (2004) The effect of maleic anhydride modified polypropylene on the mechanical properties of feather fiber, kraft pulp, polypropylene composites. J Appl Polym Sci 92:3771–3783
Cadée JA, Brouwer LA, den Otter W et al (2001) A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats. J Biomed Mater Res 56:600–609
Calkins M (2009) Materials for sustainable sites: a complete guide to the evaluation, selection, and use of sustainable construction materials. Wiley, Hoboke
Callahan TD, Natale A (2008) Catheter ablation of atrial fibrillation. Med Clin North Am 92(179–201):xii. https://doi.org/10.1016/j.mcna.2007.09.001
Capperauld I (1989) Suture materials: a review. Clin Mater 4:3–12. https://doi.org/10.1016/0267-6605(89)90021-8
Choi SM, Ryu HA, Lee K-M et al (2016) Development of stabilized growth factor-loaded Hyaluronate–Collagen Dressing (HCD) matrix for impaired wound healing. Biomater Res 20:9. https://doi.org/10.1186/s40824-016-0056-4
Ciapetti G, Cenni E, Pratelli L, Pizzoferrato A (1993) In vitro evaluation of cell/biomaterial interaction by MTT assay. Biomaterials 14:359–364. https://doi.org/10.1016/0142-9612(93)90055-7
Ciardelli G, Chiono V, Vozzi G et al (2005) Blends of poly-(epsilon-caprolactone) and polysaccharides in tissue engineering applications. Biomacromolecules 6:1961–1976. https://doi.org/10.1021/bm0500805
Cutter CN, Sumner SS (2002) Application of edible coatings on muscle foods. In: Gennedios A (ed) Protein-based films and coatings. CRC, Boca Raton, FL, pp 467–484
Cziple FA, Marques AJV (2008) Biopolymers versus synthetic polymers. Eftimie Murgu University of Resita, Romania, pp 125–132
Dalsin JL, Hu B-H, Lee BP, Messersmith PB (2003) Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces. J Am Chem Soc 125:4253–4258. https://doi.org/10.1021/ja0284963
de Vos P, Hoogmoed CG, Busscher HJ (2002) Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells. J Biomed Mater Res 60:252–259
Denkbas EB, Ozturk E, Ozdemi N et al (2003) EGF loaded chitosan sponges as wound dressing material. J Bioact Compat Polym 18:177–190. https://doi.org/10.1177/0883911503035388
Dhivya S, Padma VV, Santhini E (2015) Wound dressings—a review. BioMedicine 5:22. https://doi.org/10.7603/s40681-015-0022-9
Dickinson LE, Gerecht S (2016) Engineered biopolymeric scaffolds for chronic wound healing. Front Physiol 7:341. https://doi.org/10.3389/fphys.2016.00341
Dickerson MB, Sierra AA, Bedford NM et al (2013) Keratin-based antimicrobial textiles, films, and nanofibers. J Mater Chem B 1:5505–5514. https://doi.org/10.1039/c3tb20896f
Dou Y, Huang X, Zhang B et al (2015) Preparation and characterization of a dialdehyde starch crosslinked feather keratin film for food packaging application. RSC Adv 5:27168–27174. https://doi.org/10.1039/c4ra15469j
Draye JP, Delaey B, Van de Voorde A et al (1998) In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials 19:1677–1687
Dreifke MB, Ebraheim NA, Jayasuriya AC (2013) Investigation of potential injectable polymeric biomaterials for bone regeneration. J Biomed Mater Res A 101:2436–2447. https://doi.org/10.1002/jbm.a.34521
Edmonds M, European and Australian Apligraf Diabetic Foot Ulcer Study Group (2009) Apligraf in the treatment of neuropathic diabetic foot ulcers. Int J Low Extrem Wounds 8:11–18. https://doi.org/10.1177/1534734609331597
El Fray M, Prowans P, Puskas JE, Altstadt V (2006) Biocompatibility and fatigue properties of Polystyrene−Polyisobutylene−Polystyrene, an emerging thermoplastic elastomeric biomaterial. Biomacromolecules 7:844–850. https://doi.org/10.1021/bm050971c
El Ghalbzouri A, Hensbergen P, Gibbs S et al (2004) Fibroblasts facilitate re-epithelialization in wounded human skin equivalents. Lab Invest 84:102–112. https://doi.org/10.1038/sj.labinvest.3700014
Epstein FH, Singer AJ, Clark RAF (1999) Cutaneous wound healing. N Engl J Med 341:738–746. https://doi.org/10.1056/nejm199909023411006
Falanga V, Isaacs C, Paquette D et al (2002) Wounding of bioengineered skin: cellular and molecular aspects after injury. J Invest Dermatol 119:653–660. https://doi.org/10.1046/j.1523-1747.2002.01865.x
Feughelman M (1959) A two-phase structure for keratin fibers. Text Res J 29:223–228
Fine DM, Tobias AH (2007) Cardiovascular device infections in dogs: report of 8 cases and review of the literature. J Vet Intern Med 21:1265–1271
Frazier OH, Jacob LP (2007) Small pumps for ventricular assistance: progress in mechanical circulatory support. Cardiol Clin 25(553–64):vi. https://doi.org/10.1016/j.ccl.2007.09.001
Geiger M, Li RH, Friess W (2003) Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 55:1613–1629
Gupta P, Nayak KK (2015a) Characteristics of protein-based biopolymer and its application. Polym Eng Sci 55:485–498. https://doi.org/10.1002/pen.23928
Gupta P, Nayak KK (2015b) Compatibility study of alginate/keratin blend for biopolymer development. J Appl Biomater Funct Mater 13:e332–e339. https://doi.org/10.5301/jabfm.5000242
Gupta P, Nayak KK (2016) Optimization of keratin/alginate scaffold using RSM and its characterization for tissue engineering. Int J Biol Macromol 85:141–149. https://doi.org/10.1016/j.ijbiomac.2015.12.010
Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453:314–321. https://doi.org/10.1038/nature07039
Harrison J, Pattanawong S, Forsythe JS et al (2004) Colonization and maintenance of murine embryonic stem cells on poly(alpha-hydroxy esters). Biomaterials 25:4963–4970. https://doi.org/10.1016/j.biomaterials.2004.01.054
He Y, Lu F (2016) Development of synthetic and natural materials for tissue engineering applications using adipose stem cells. Stem Cells Int 2016:5786257. https://doi.org/10.1155/2016/5786257
Hemsri S, Asandei AD, Grieco K, Parnas RS (2011) Biopolymer composites of wheat gluten with silica and alumina. Compos Part A: Appl Sci Manuf 42:1764–1773. https://doi.org/10.1016/j.compositesa.2011.07.032
Hu S, Kirsner RS, Falanga V et al (2006) Evaluation of Apligraf® persistence and basement membrane restoration in donor site wounds: a pilot study. Wound Repair Regen 14:427–433. https://doi.org/10.1111/j.1743-6109.2006.00148.x
Huang X, Zhang Y, Zhang X et al (2013) Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Mater Sci Eng, C 33:4816–4824. https://doi.org/10.1016/j.msec.2013.07.044
Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543. https://doi.org/10.1016/s0142-9612(00)00121-6
Isarankura Na Ayutthaya S, Tanpichai S, Wootthikanokkhan J (2015) Keratin extracted from chicken feather waste: extraction, preparation, and structural characterization of the keratin and keratin/biopolymer films and electrospuns. J Polym Environ 23:506–516. https://doi.org/10.1007/s10924-015-0725-8
Jung Y, Kim S-S, Kim YH et al (2005) A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering. Biomaterials 26:6314–6322. https://doi.org/10.1016/j.biomaterials.2005.04.007
Karthikeyan R, Balaji S, Sehgal PK (2007) Industrial applications of keratins—a review. J Sci Ind Res 66:710–715
Keong LC, Halim AS (2009) In vitro models in biocompatibility assessment for biomedical-grade chitosan derivatives in wound management. Int J Mol Sci 10:1300–1313. https://doi.org/10.3390/ijms10031300
Khan F, Tanaka M, Ahmad SR et al (2015) Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices. J Mater Chem B 3:8224–8249. https://doi.org/10.1039/c5tb01370d
Khor E, Lim LY (2003) Implantable applications of chitin and chitosan. Biomaterials 24:2339–2349
Kipshidze NN, Tsapenko MV, Leon MB et al (2005) Update on drug-eluting coronary stents. Expert Rev Cardiovasc Ther 3:953–968. https://doi.org/10.1586/14779072.3.5.953
Kizilel S, Garfinkel M, Opara E (2005) The bioartificial pancreas: progress and challenges. Diabetes Technol Ther 7:968–985. https://doi.org/10.1089/dia.2005.7.968
Koschwanez HE, Reichert WM (2007) In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations. Biomaterials 28:3687–3703. https://doi.org/10.1016/j.biomaterials.2007.03.034
Kumar P, Vinitha B, Fathima G (2013) Bone grafts in dentistry. J Pharm Bioallied Sci 5:S125–S127. https://doi.org/10.4103/0975-7406.113312
Kumaran P, Gupta A, Sharma S (2017) Synthesis of wound-healing keratin hydrogels using chicken feathers proteins and its properties. Int J Pharm Pharm Sci 9:171. https://doi.org/10.22159/ijpps.2017v9i2.15620
Landsman AS, Cook J, Cook E et al (2011) A retrospective clinical study of 188 consecutive patients to examine the effectiveness of a biologically active cryopreserved human skin allograft (TheraSkin®) on the treatment of diabetic foot ulcers and venous leg ulcers. Foot Ankle Spec 4:29–41. https://doi.org/10.1177/1938640010387417
Levingstone TJ, Matsiko A, Dickson GR et al (2014) A biomimetic multi-layered collagen-based scaffold for osteochondral repair. Acta Biomater 10:1996–2004. https://doi.org/10.1016/j.actbio.2014.01.005
Li J-S, Li Y, Liu X et al (2013) Strategy to introduce an hydroxyapatite–keratin nanocomposite into a fibrous membrane for bone tissue engineering. J Mater Chem B 1:432–437. https://doi.org/10.1039/c2tb00460g
Li X, Cui R, Sun L et al (2014) 3D-printed biopolymers for tissue engineering application. Int J Polym Sci 2014:1–13. https://doi.org/10.1155/2014/829145
Liu H, Slamovich EB, Webster TJ (2006) Less harmful acidic degradation of poly(lacticco-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition. Int J Nanomedicine 1:541–545
Lu L, Peter SJ, Lyman MD et al (2000) In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams. Biomaterials 21:1837–1845. https://doi.org/10.1016/s0142-9612(00)00047-8
Lu T, Qiao Y, Liu X (2012) Surface modification of biomaterials using plasma immersion ion implantation and deposition. Interface Focus 2:325–336. https://doi.org/10.1098/rsfs.2012.0003
Lunsford L, McKeever U, Eckstein V, Hedley ML (2000) Tissue distribution and persistence in mice of plasmid DNA encapsulated in a PLGA-based microsphere delivery vehicle. J Drug Target 8:39–50. https://doi.org/10.3109/10611860009009208
Ma PX (2008) Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 60:184–198. https://doi.org/10.1016/j.addr.2007.08.041
Maitz MF (2015) Applications of synthetic polymers in clinical medicine. Biosurface Biotribology 1:161–176. https://doi.org/10.1016/j.bsbt.2015.08.002
Marques AP, Reis RL, Hunt JA (2002) The biocompatibility of novel starch-based polymers and composites: in vitro studies. Biomaterials 23:1471–1478. https://doi.org/10.1016/s0142-9612(01)00272-1
Marston WA, Hanft J, Norwood P et al (2003) The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care 26:1701–1715
Maruoka S, Matsuura T, Kawasaki K et al (2006) Biocompatibility of polyvinylalcohol gel as a vitreous substitute. Curr Eye Res 31:599–606. https://doi.org/10.1080/02713680600813854
Matsumoto T, Okazaki M, Nakahira A et al (2007) Modification of apatite materials for bone tissue engineering and drug delivery carriers. Curr Med Chem 14:2726–2733
McKittrick J, Chen P-Y, Bodde SG et al (2012) The structure, functions, and mechanical properties of keratin. JOM 64:449–468. https://doi.org/10.1007/s11837-012-0302-8
Mendes SC, Reis RL, Bovell YP et al (2001) Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery: a preliminary study. Biomaterials 22:2057–2064
Meyers MA, Chen P-Y (2014) Biological materials science: biological materials, bioinspired materials, and biomaterials. Cambridge University Press and the Materials Research Society, Cambridge
Moses JW, Kipshidze N, Leon MB (2002) Perspectives of drug-eluting stents: the next revolution. Am J Cardiovasc Drugs 2:163–172
Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32:773–785. https://doi.org/10.1038/nbt.2958
Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32:762–798. https://doi.org/10.1016/j.progpolymsci.2007.05.017
Naughton G, Mansbridge J, Gentzkow G (1997) A metabolically active human dermal replacement for the treatment of diabetic foot ulcers. Artif Organs 21:1203–1210
Nayak KK, Gupta P (2015) In vitro biocompatibility study of keratin/agar scaffold for tissue engineering. Int J Biol Macromol 81:1–10. https://doi.org/10.1016/j.ijbiomac.2015.07.025
Nayak KK, Gupta P (2017) Study of the keratin-based therapeutic dermal patches for the delivery of bioactive molecules for wound treatment. Mater Sci Eng, C 77:1088–1097. https://doi.org/10.1016/j.msec.2017.04.042
Nilsson M, Zheng MH, Tägil M (2013) The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications. Expert Rev Med Devices 10:675–684. https://doi.org/10.1586/17434440.2013.827529
Nozynski JK, Religa Z, Wszołek J et al (2001) Biological heart valve an alternative to mechanical valve. Med Sci Monit 7:550–562
O’Brien FJ (2011) Biomaterials & scaffolds for tissue engineering. Mater Today 14:88–95. https://doi.org/10.1016/s1369-7021(11)70058-x
O’Connor RC, Lyon MB, Guralnick ML, Bales GT (2008) Long-term follow-up of single versus double cuff artificial urinary sphincter insertion for the treatment of severe postprostatectomy stress urinary incontinence. Urology 71:90–93. https://doi.org/10.1016/j.urology.2007.08.017
Oh S (2003) Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials 24:4011–4021. https://doi.org/10.1016/s0142-9612(03)00284-9
Panchal B, Bagdadi A, Roy I (2013) Polyhydroxyalkanoates: the natural polymers produced by bacterial fermentation. In: Thomas S, Visakh P, Mathew A (eds) Advances in natural polymers, vol 18. Springer, Berlin, pp 397–421
Paradossi G, Cavalieri F, Chiessi E et al (2003) Poly(vinyl alcohol) as versatile biomaterial for potential biomedical applications. J Mater Sci Mater Med 14:687–691
Parker AC, Smith JK, Courtney HS, Haggard WO (2011) Evaluation of two sources of calcium sulfate for a local drug delivery system: a pilot study. Clin Orthop Relat Res 469:3008–3015. https://doi.org/10.1007/s11999-011-1911-1
Pereira TF, Oliveira MF, Maia IA et al (2012) 3D printing of poly(3-hydroxybutyrate) porous structures using selective laser sintering. Macromol Symp 319:64–73. https://doi.org/10.1002/masy.201100237
Petrulyte S (2008) Advanced textile materials and biopolymers in wound management. Dan Med Bull 55:72–77
Pol H, Dawson P, Acton J, Ogale A (2002) Soy protein isolate/corn-zein laminated films: transport and mechanical properties. J Food Sci 67:212–217
Ramakrishnan N, Sharma S, Gupta A, Alashwal BY (2018) Keratin based bioplastic film from chicken feathers and its characterization. Int J Biol Macromol 111:352–358. https://doi.org/10.1016/j.ijbiomac.2018.01.037
Ramirez DOS, Carletto RA, Tonetti C et al (2017) Wool keratin film plasticized by citric acid for food packaging. Food Packag Shelf Life 12:100–106. https://doi.org/10.1016/J.FPSL.2017.04.004
Rath G, Hussain T, Chauhan G et al (2015) Collagen nanofiber containing silver nanoparticles for improved wound-healing applications. J Drug Target 1–10. https://doi.org/10.3109/1061186x.2015.1095922
Reichl S (2009) Films based on human hair keratin as substrates for cell culture and tissue engineering. Biomaterials 30:6854–6866. https://doi.org/10.1016/j.biomaterials.2009.08.051
Restle L, Costa-Silva D, Loureno ES et al (2015) A 3D osteoblast in vitro model for the evaluation of biomedical materials. Adv Mater Sci Eng 2015:1–8. https://doi.org/10.1155/2015/268930
Richards DJ, Tan Y, Jia J et al (2013) 3D printing for tissue engineering. Isr J Chem 53:805–814
Rosellini E, Cristallini C, Barbani N et al (2009) Preparation and characterization of alginate/gelatin blend films for cardiac tissue engineering. J Biomed Mater Res, Part A 91:447–453. https://doi.org/10.1002/jbm.a.32216
Rowlands AS, Lim SA, Martin D, Cooper-White JJ (2007) Polyurethane/poly(lactic-co-glycolic) acid composite scaffolds fabricated by thermally induced phase separation. Biomaterials 28:2109–2121. https://doi.org/10.1016/j.biomaterials.2006.12.032
Royals MA, Fujita SM, Yewey GL et al (1999) Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys. J Biomed Mater Res 45:231–239
Rujitanaroj P, Pimpha N, Supaphol P (2008) Wound-dressing materials with antibacterial activity from electrospun gelatin fiber mats containing silver nanoparticles. Polymer (Guildf) 49:4723–4732. https://doi.org/10.1016/j.polymer.2008.08.021
Salgado AJ, Coutinho OP, Reis RL (2004) Bone tissue engineering: state of the art and future trends. Macromol Biosci 4:743–765. https://doi.org/10.1002/mabi.200400026
Santoro M, Gaudino G (2005) Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res 304:274–286. https://doi.org/10.1016/j.yexcr.2004.10.033
Sarabahi S (2012) Recent advances in topical wound care. Indian J Plast Surg 45:379–387. https://doi.org/10.4103/0970-0358.101321
Saravanan S, Sameera DK, Moorthi A, Selvamurugan N (2013) Chitosan scaffolds containing chicken feather keratin nanoparticles for bone tissue engineering. Int J Biol Macromol 62:481–486. https://doi.org/10.1016/j.ijbiomac.2013.09.034
Schuster J (2003) Polypropylene reinforced with chicken feathers. In: International conference on composite materials (ICCM-14), San Diego, CA
Sharma S, Gupta A (2016) Sustainable management of keratin waste biomass: applications and future perspectives. Braz Arch Biol Technol 59:1–14. https://doi.org/10.1590/1678-4324-2016150684
Sharma S, Gupta A, Kumar A et al (2018) An efficient conversion of waste feather keratin into ecofriendly bioplastic film. Clean Technol Environ Policy 1–11. https://doi.org/10.1007/s10098-018-1498-2
Shi W, Dumont MJ (2014) Review: bio-based films from zein, keratin, pea, and rapeseed protein feedstocks. J Mater Sci 49:1915–1930. https://doi.org/10.1007/s10853-013-7933-1
Silva R, Singh R, Sarker B et al (2014) Hybrid hydrogels based on keratin and alginate for tissue engineering. J Mater Chem B 2:5441–5451. https://doi.org/10.1039/c4tb00776j
Song E, Yeon Kim S, Chun T et al (2006) Collagen scaffolds derived from a marine source and their biocompatibility. Biomaterials 27:2951–2961. https://doi.org/10.1016/j.biomaterials.2006.01.015
Spector M (2007) Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly 137(Suppl):157S–165S
Tanabe T, Okitsu N, Tachibana A, Yamauchi K (2002) Preparation and characterization of keratin–chitosan composite film. Biomaterials 23:817–825
Tracy LE, Minasian RA, Caterson EJ (2016) Extracellular matrix and dermal fibroblast function in the healing wound. Adv Wound Care 5:119–136. https://doi.org/10.1089/wound.2014.0561
Tsai WB, Grunkemeier JM, McFarland CD, Horbett TA (2002) Platelet adhesion to polystyrene-based surfaces preadsorbed with plasmas selectively depleted in fibrinogen, fibronectin, vitronectin, or von Willebrand’s factor. J Biomed Mater Res 60:348–359
Vasconcelos A, Cavaco-Paulo A (2013) The use of keratin in biomedical applications. Curr Drug Targets 14:612–619
Vazquez N, Chacón M, Meana A et al (2015) Keratin–chitosan membranes as scaffold for tissue engineering of human cornea. Histol Histopathol 30:813–821. http://dx.doi.org/10.14670/HH-11-585
Vercruysse KP, Prestwich GD (1998) Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 15:513–555
Veves A, Falanga V, Armstrong DG et al (2001) Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. Diabetes Care 24:290–295
Wang YX, Cao XJ (2012) Extracting keratin from chicken feathers by using a hydrophobic ionic liquid. Process Biochem 47(5): 896–899
Wang YC, Lin MC, Wang DM, Hsieh HJ (2003) Fabrication of a novel porous PGA-chitosan hybrid matrix for tissue engineering. Biomaterials 24:1047–1057
Wang HM, Chou YT, Wen ZH et al (2013) Novel biodegradable porous scaffold applied to skin regeneration. PLoS ONE 8:1–11. https://doi.org/10.1371/journal.pone.0056330
Williams DF (2011) The Williams dictionary of biomaterials. Liverpool University Press, Liverpool
Wrzesniewska-Tosik K, Adamiec J (2007) Biocomposites with a content of keratin from chicken feathers. Fibres Text East Eur 15:106–112
Xing ZC, Yuan J, Chae WP et al (2011) Keratin nanofibers as a biomaterial. In: 2010 international conference on nanotechnology and biosensors (IPCBEE), pp 120–124
Xiong H, Tang S, Tang H, Zou P (2008) The structure and properties of a starch-based biodegradable film. Carbohydr Polym 71:263–268. https://doi.org/10.1016/j.carbpol.2007.05.035
Xu H, Cai S, Xu L, Yang Y (2014) Water-stable three-dimensional ultrafine fibrous scaffolds from keratin for cartilage tissue engineering. Langmuir 30:8461–8470. https://doi.org/10.1021/la500768b
Xu H, Ma L, Shi H et al (2007) Chitosan–hyaluronic acid hybrid film as a novel wound dressing: in vitro and in vivo studies. Polym Adv Technol 18:869–875. https://doi.org/10.1002/pat
Yang J, Wang N, Chiu H (2014) Preparation and characterization of poly(vinyl alcohol)/sodium alginate blended membrane for alkaline solid polymer electrolytes membrane. J Memb Sci 457:139–148. https://doi.org/10.1016/j.memsci.2014.01.034
Yu X, Tang X, Gohil SV, Laurencin CT (2015) Biomaterials for bone regenerative engineering. Adv Healthc Mater 4:1268–1285. https://doi.org/10.1002/adhm.201400760
Yun YR, Won JE, Jeon E et al (2010) Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng 1:218142. https://doi.org/10.4061/2010/218142
Zaulyanov L, Kirsner RS (2007) A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. Clin Interv Aging 2:93–98
Zhang L, Li K, Xiao W et al (2011) Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro. Carbohydr Polym 84:118–125. https://doi.org/10.1016/j.carbpol.2010.11.009
Zhijiang C, Chengwei H, Guang Y (2012) Poly(3-hydroxubutyrate-co-4-hydroxubutyrate)/bacterial cellulose composite porous scaffold: preparation, characterization and biocompatibility evaluation. Carbohydr Polym 87:1073–1080. https://doi.org/10.1016/j.carbpol.2011.08.037
Zhu W, Ma X, Gou M et al (2016) 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotechnol 40:103–112. https://doi.org/10.1016/J.COPBIO.2016.03.014
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Nayak, K.K., Parkhey, P., Mazumdar, B. (2019). Keratin-Based Biotechnological Applications. In: Sharma, S., Kumar, A. (eds) Keratin as a Protein Biopolymer. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-02901-2_8
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