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Adiponectin: An Adipokine with Multiple Faces

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Physiology and Physiopathology of Adipose Tissue

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Abstract

Adipose tissue has long been considered as an “organ” of energy storage but it is also capable of synthesizing and releasing various factors called adipokines, such as adiponectin. Adiponectin is the most abundant adipose tissue transcript that displays insulin sensitizing and anti-inflammatory properties. The complexity of adiponectin multi-functionality is illustrated in kidney diseases, where plasma hormone levels predict fatal issue, despite its antiinflammatory, anti-atherogenic, and insulin-sensitizing properties. This is also highlighted in severe forms of insulin resistance in patients with receptor dysfunction who present elevated adiponectinemia, whereas patients with common form of insulin resistance have low adiponectin levels. Finally, the role of adiponectin in carcinogenesis and in other physiological and pathological contexts is described.

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Authors and Affiliations

  1. Institut des maladies cardiométaboliques et de la nutrition (IHU ICAN), Paris, France

    Jean-Philippe Bastard, Camille Vatier & Bruno Fève

  2. Faculté de Médecine Pierre et Marie Curie site Saint-Antoine, INSERM, UPMC, UMR_S938, Paris, France

    Bruno Fève

  3. Faculté de Médecine Pierre et Marie Curie site Saint-Antoine, INSERM, UPMC, UMR_S938, 27 rue Chaligny, 75012, Paris, France

    Jean-Philippe Bastard

  4. Service d’Endocrinologie-Métabolisme, Hôpital Saint-Antoine, 27 rue Chaligny, 75571, Paris cedex 12, France

    Bruno Fève

  5. Faculté de Médecine Pierre et Marie Curie site Saint-Antoine, INSERM, UPMC, UMR_S938, 27 rue Chaligny, 75012, Paris, France

    Camille Vatier

  6. Service de Biochimie et Hormonologie, Hôpital Tenon, 4 rue de la Chine, 75970, Paris cedex 20, France

    Jean-Philippe Bastard

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  1. Jean-Philippe Bastard
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  2. Camille Vatier
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Correspondence to Jean-Philippe Bastard .

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  1. Rue de la Chine 4, Paris, 75020, France

    Jean-Philippe Bastard

  2. Hôpital Saint-Antoine, Paris, France

    Bruno Fève

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Bastard, JP., Vatier, C., Fève, B. (2013). Adiponectin: An Adipokine with Multiple Faces. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_13

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