Résumé
Le tissu adipeux (TA) blanc est le principal lieu de stockage énergétique chez les mammifères. Il joue un rôle crucial dans la balance énergétique aussi bien au niveau cellulaire que de l’organisme entier, stockant l’énergie sous forme de triacylglycérols (ou triglycérides, TG) après les repas et les libérant pour les autres organes sous la forme d’acides gras (AG) non estérifiés durant le jeûne ou l’exercice. De ce fait, les voies de signalisation contrôlant l’accumulation des graisses (consommation cellulaire d’AG, lipogenèse de novo et estérification en TG) et leur mobilisation (lipolyse) dans les adipocytes sont étroitement corégulées. Alors que la synthèse des TG se produit dans plusieurs tissus, tels que le foie pour la production de lipoprotéines à basse densité, la lipolyse permettant la libération des AG comme source d’énergie pour les autres tissus est uniquement imputable aux cellules adipeuses (adipocytes). La compréhension des acteurs cellulaires et moléculaires régulant ces processus métaboliques est en constante progression. Des découvertes récentes ont démontré l’importance de nouveaux acteurs moléculaires dans la régulation de la lipolyse. élucider les modes de fonctionnement de ces nouvelles voies pourrait conduire à de nouvelles cibles thérapeutiques visant au traitement de l’obésité et des désordres métaboliques qui lui sont associés.
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Mouisel, E., Langin, D. (2013). La lipolyse adipocytaire. In: Physiologie et physiopathologie du tissu adipeux. Springer, Paris. https://doi.org/10.1007/978-2-8178-0332-6_10
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DOI: https://doi.org/10.1007/978-2-8178-0332-6_10
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