Abstract
Ultrasound (US) is the most common and least invasive modality for clinical imaging of the kidney. One important application of US in nephrology is the detection and monitoring of structural changes in the kidney. Recent advances in US technology have facilitated the application of similar techniques to animal models of human disease. We have developed a simple US-based method of detection and quantitation of hydronephrosis in a mouse model of congenital obstructive nephropathy, the megabladder (mgb) mouse.
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References
Singh S, Robinson M, Nahi F et al (2007) Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction. J Am Soc Nephrol 18:461–471
Ingraham SE, Saha M, Carpenter AR et al (2010) Pathogenesis of renal injury in the megabladder mouse: a genetic model of congenital obstructive nephropathy. Pediatr Res 68: 500–507
Acknowledgment
This work was supported by NIH grants DK070907 and DK085242.
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© 2012 Springer Science+Business Media, LLC
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Carpenter, A.R., Becknell, B., Ingraham, S.E., McHugh, K.M. (2012). Ultrasound Imaging of the Murine Kidney. In: Michos, O. (eds) Kidney Development. Methods in Molecular Biology™, vol 886. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-851-1_35
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DOI: https://doi.org/10.1007/978-1-61779-851-1_35
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-850-4
Online ISBN: 978-1-61779-851-1
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