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Recent Advances and Future Challenges in Glycan Microarray Technology

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Carbohydrate Microarrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 808))

Abstract

Glycan microarrays, carrying hundreds of different sugars on chip surfaces, have become a standard tool for the study of interactions of biomolecules with carbohydrates. The chip-based format offers important advantages, including the ability to screen in parallel several thousand binding events on a single slide, the minimal amount of sample required for one experiment, and the multivalent display of sugars on the chip that mimics the presentation of carbohydrates in nature. This chapter presents recent advances and future challenges in glycan microarray technology. We describe different immobilization and detection methods as well as applications in glycomics, drug discovery, and biomedicine.

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Acknowledgments

We thank the Spanish Research Council (CSIC) (Grant 200880I041), the Spanish Ministry of Science and Innovation (Grant CTQ2009-07168), Junta de Andalucía (Grant P07-FQM-02969, “Incentivo a Proyecto Internacional”), and the European Union (FEDER support and Marie Curie Reintegration Grant) for financial support. Generous financial support from the Max-Planck Society is gratefully acknowledged.

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Authors and Affiliations

  1. Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de la Cartuja, CSIC and US, Sevilla, Spain

    José L. de Paz

  2. Max-Planck Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Freie Universität Berlin, Berlin, Germany

    Peter H. Seeberger

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  1. José L. de Paz
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  2. Peter H. Seeberger
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Correspondence to José L. de Paz .

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Editors and Affiliations

  1. CNRS UMR 5270, Inst. Nanotechnologies de Lyon, Université Lyon 1, av. Guy de Collongue 36, Ecully, 69134, France

    Yann Chevolot

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de Paz, J.L., Seeberger, P.H. (2012). Recent Advances and Future Challenges in Glycan Microarray Technology. In: Chevolot, Y. (eds) Carbohydrate Microarrays. Methods in Molecular Biology, vol 808. Humana Press. https://doi.org/10.1007/978-1-61779-373-8_1

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  • DOI: https://doi.org/10.1007/978-1-61779-373-8_1

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