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MRI in Animal Models of Psychiatric Disorders

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In vivo NMR Imaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 771))

Abstract

Here we describe MRI and 1H MRS protocols for the investigation of animal models (mainly mice and rats) of psychiatric disorders. The introduction provides general findings from brain imaging studies in patients with psychiatric diseases and refers to general rules regarding the use of animal models in research. The methods section includes a selection of basic 9.4 T MRI and MRS protocols applicable for the investigation of animal models of psychiatric disorders (T1W, T2W, FLAIR, 1H MRS). The notes section discusses in detail a series of factors that can influence the outcome of the experiment: from animal handling, stress-triggering aspects, and experimental design-related factors to technical aspects that affect T 1 and T 2 measurements.

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Authors and Affiliations

  1. Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands

    Dana S. Poole

  2. Division of Medical Pharmacology, University of Leiden, Leiden, The Netherlands

    Melly S. Oitzl

  3. Department of Radiology, Anatomy and Embryology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands

    Louise van der Weerd

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  1. Dana S. Poole
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  2. Melly S. Oitzl
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  3. Louise van der Weerd
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Correspondence to Louise van der Weerd .

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Editors and Affiliations

  1. ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmako, Robert-Roessle-Str. 10, Berlin, 13125, Germany

    Leif Schröder

  2. Inst. Klinische Radiologie, AG Experimentelle, Universität Münster, Haus Rosenbach Waldeyerstr. 1, Münster, 48149, Germany

    Cornelius Faber

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Poole, D.S., Oitzl, M.S., van der Weerd, L. (2011). MRI in Animal Models of Psychiatric Disorders. In: Schröder, L., Faber, C. (eds) In vivo NMR Imaging. Methods in Molecular Biology, vol 771. Humana Press. https://doi.org/10.1007/978-1-61779-219-9_17

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