Abstract
The development of obesity induces resistance to the effect of insulin to stimulate uptake of glucose and suppress release of fatty acids. These metabolic impairments are inter-related and competition between glucose and fatty acids i s a key aspect of the pathogenesis of insulin resistance. Another important factor is that fat calories accumulate within muscle and liver and the presence of an increased fat content in these organs correlates with severity of insulin resistance. This chapter reviews recent findings and background concepts regarding “ectopic fat” and substrate competition and how these contribute to obesity induced insulin resistance.
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© 2007 Humana Press Inc., Totowa, NJ
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Kelley, D.E. (2007). Free Fatty Acids, Insulin Resistance, and Ectopic Fat. In: Kushner, R.F., Bessesen, D.H. (eds) Treatment of the Obese Patient. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-400-1_5
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DOI: https://doi.org/10.1007/978-1-59745-400-1_5
Publisher Name: Humana Press
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