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The Analysis of Ethnic Mixtures

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Statistical Human Genetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1666))

Abstract

Population of ethnic mixtures can be useful in genetic studies. Admixture mapping, or mapping by admixture linkage disequilibrium (MALD), is specially developed for admixed populations and can supplement traditional genome-wide association analyses in the search for genetic variants underlying complex traits. Admixture mapping tests the association between a trait and locus-specific ancestries. The locus-specific ancestries are in linkage disequilibrium (LD), which is generated by an admixture process between genetically distinct ancestral populations. Because of the highly correlated-locus specific ancestries, admixture mapping performs many fewer independent tests across the genome than current genome-wide association analysis. Therefore, admixture mapping can be more powerful because it reduces the penalty due to multiple tests. In this chapter, we introduce the theory behind admixture mapping and explain how to conduct the analysis in practice.

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Acknowledgment

This work was supported by a grant from the National Human Genome Research Institute (HG003054).

Author information

Authors and Affiliations

  1. Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA

    Xiaofeng Zhu & Heming Wang

  2. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    Heming Wang

  3. Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA

    Heming Wang

Authors
  1. Xiaofeng Zhu
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  2. Heming Wang
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Corresponding author

Correspondence to Xiaofeng Zhu .

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, OH, USA

    Robert C. Elston

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Zhu, X., Wang, H. (2017). The Analysis of Ethnic Mixtures. In: Elston, R. (eds) Statistical Human Genetics. Methods in Molecular Biology, vol 1666. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7274-6_25

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  • DOI: https://doi.org/10.1007/978-1-4939-7274-6_25

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7273-9

  • Online ISBN: 978-1-4939-7274-6

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