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Correcting for Ascertainment

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Statistical Human Genetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1666))

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Abstract

Data used to study human genetics are often not obtained by simple random sampling, which is assumed by many statistical methods, especially those that are based on likelihood for making inferences. There is a well-developed theory to correct likelihoods based on sibship data whether or not the exact mode of ascertainment is known. In the case of larger pedigrees, however, the problem is much more difficult unless they are recruited into the sample by single ascertainment. There is no one piece of software that analyzes ascertainment in general, so most of this chapter is devoted to theory. A general method by which one general genetic analysis software package corrects pedigree data for ascertainment is briefly described.

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Author information

Authors and Affiliations

  1. Department of Biology, University of Pennsylvania, 3601 Locust Walk, Philadelphia, PA, 19104, USA

    Warren Ewens

  2. Case Western Reserve University, Cleveland, OH, USA

    Robert C. Elston

Authors
  1. Warren Ewens
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  2. Robert C. Elston
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Corresponding author

Correspondence to Warren Ewens .

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, OH, USA

    Robert C. Elston

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© 2017 Springer Science+Business Media LLC

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Ewens, W., Elston, R.C. (2017). Correcting for Ascertainment. In: Elston, R. (eds) Statistical Human Genetics. Methods in Molecular Biology, vol 1666. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7274-6_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7274-6_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7273-9

  • Online ISBN: 978-1-4939-7274-6

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