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Determining the Virus Life-Cycle Stage Blocked by an Antiviral

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Hemorrhagic Fever Viruses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1604))

Abstract

Among the members of the Arenaviridae family, Junín virus and Lassa virus represent important human health threats generating annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of Argentina and Western Africa, respectively. Given the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. During the last two decades, academic research studies originated important results identifying novel molecules to be considered for further in vivo characterization. This chapter summarizes experimental in vitro approaches used to determine the possible mechanism of action of these antiviral agents.

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Authors and Affiliations

  1. Laboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

    Claudia S. Sepúlveda, Cybele C. García & Elsa B. Damonte

  2. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), UBA-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

    Claudia S. Sepúlveda, Cybele C. García & Elsa B. Damonte

Authors
  1. Claudia S. Sepúlveda
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  2. Cybele C. García
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  3. Elsa B. Damonte
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Corresponding author

Correspondence to Elsa B. Damonte .

Editor information

Editors and Affiliations

  1. School of Medicine, University of Maryland, Baltimore, Maryland, USA

    Maria S. Salvato

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Sepúlveda, C.S., García, C.C., Damonte, E.B. (2018). Determining the Virus Life-Cycle Stage Blocked by an Antiviral. In: Salvato, M. (eds) Hemorrhagic Fever Viruses. Methods in Molecular Biology, vol 1604. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6981-4_28

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  • DOI: https://doi.org/10.1007/978-1-4939-6981-4_28

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6980-7

  • Online ISBN: 978-1-4939-6981-4

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