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Synthetic Antibodies pp 3–13Cite as

Antibody Mimetics, Peptides, and Peptidomimetics

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1575))

Abstract

In spite of their widespread applications as therapeutic, diagnostic, and detection agents, the limitations of polyclonal and monoclonal antibodies have enthused scientists to plan for next-generation biomedical agents, the so-called antibody mimetics, which offer many advantages compared to traditional antibodies. Antibody mimetics could be designed through protein-directed evolution or fusion of complementarity-determining regions with intervening framework regions. In the recent decade, extensive progress has been made in exploiting human, butterfly (Pieris brassicae), and bacterial systems to design and select mimetics using display technologies. Notably, some of the mimetics have made their way to market. Numerous limitations lie ahead in developing mimetics for different biomedical usage, particularly for which conventional antibodies are ineffective. This chapter presents a brief overview of the current characteristics, construction, and applications of antibody mimetics.

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Acknowledgements

This work has been supported by China Nature Science Foundation (grant no. 31572556), Ph.D. Programs Foundation of Ministry of Education (grant no. 20130204110023), and The Key Construction Program (grant no. 2015SD0018) of International Cooperation Base in S&T, Shaanxi Province, China.

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Authors and Affiliations

  1. College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, 712100, Shaanxi, China

    Xiaoying Zhang & Thirumalai Diraviyam

  2. Department of Microbiology, Karpagam University, Coimbatore, Tamil Nadu, India

    Thirumalai Diraviyam

Authors
  1. Xiaoying Zhang
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  2. Thirumalai Diraviyam
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Correspondence to Xiaoying Zhang .

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Editors and Affiliations

  1. MorphoSys AG, Discovery Alliances & Technologies, Planegg, Germany

    Thomas Tiller

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Zhang, X., Diraviyam, T. (2017). Antibody Mimetics, Peptides, and Peptidomimetics. In: Tiller, T. (eds) Synthetic Antibodies. Methods in Molecular Biology, vol 1575. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6857-2_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6857-2_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6855-8

  • Online ISBN: 978-1-4939-6857-2

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