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Phosphoinositide Turnover, Ca2+ Mobilization, and Protein Kinase C Activation in GnRH Action on Pituitary Gonadotropin Release

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Endocrinology and Physiology of Reproduction

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Abstract

Gonadotropin releasing hormone (GnRH) stimulates the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from pituitary gonadotrophs. A signal-transduction mechanism transfers the biological information from the activated receptor to the cell machinery culminating in exocytosis and gene expression. Since the major cyclic nucleotides (cAMP and cGMP) and the prostaglandins were ruled out as potential second messengers for the acute actions of GnRH on gonadotropin secretion (for review see Naor, 1982; Catt et al., 1983), alternative signal-transduction mechanism was investigated.

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Author information

Authors and Affiliations

  1. Department of Hormone Research, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Zvi Naor

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  1. Zvi Naor
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Editor information

Editors and Affiliations

  1. The University of British Columbia, Vancouver, British Columbia, Canada

    P. C. K. Leung

  2. University of Western Ontario, London, Ontario, Canada

    D. T. Armstrong

  3. Dalhousie University, Halifax, Nova Scotia, Canada

    K. B. Ruf  & W. H. Moger  & 

  4. University of Manitoba, Winnipeg, Manitoba, Canada

    H. G. Friesen

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© 1987 Springer Science+Business Media New York

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Naor, Z. (1987). Phosphoinositide Turnover, Ca2+ Mobilization, and Protein Kinase C Activation in GnRH Action on Pituitary Gonadotropin Release. In: Leung, P.C.K., Armstrong, D.T., Ruf, K.B., Moger, W.H., Friesen, H.G. (eds) Endocrinology and Physiology of Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1971-7_13

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  • DOI: https://doi.org/10.1007/978-1-4899-1971-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1973-1

  • Online ISBN: 978-1-4899-1971-7

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