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Possible Role of Neuropeptide Y in Experimental Cancer Anorexia

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Diet and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 375))

Abstract

Anorexia and the concomitant depletion of host tissue (cachexia) are commonly observed in cancer patients.1 As many as 75% of cancer patients will exhibit anorexia,2 and this was recognized as early as 1930 as a major contributor to death of cancer patients.3 These aspects of cancer present very difficult problems for both the patient and physician in that the aggressive use of various therapies is severely limited in the cachectic patient.4 In addition, the development of anorexia in cancer patients is associated with increased morbidity and mortality.5

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References

  1. G. Costa, Cachexia, the metabolic component of neoplastic diseases, Cancer Res 37:2327 (1977).

    PubMed  CAS  Google Scholar 

  2. S.D. Morrison, Control of food intake in cancer cachexia: A challenge and a tool, Physiol Behav 17:705 (1976).

    Article  PubMed  CAS  Google Scholar 

  3. S. Warren, The immediate causes of death in cancer, Am J Med Sci 184:610 (1932).

    Article  Google Scholar 

  4. W.D. DeWys, C. Begg, P.T. Lavin, Prognostic effect of weight loss prior to chemotherapy in cancer patients, Am J Med Sci 69:491 (1980).

    Article  CAS  Google Scholar 

  5. V.J. Lanzotti, D.R. Thomas, L.E. Boyle, et al., Survival with inoperable lung cancer: An integration of prognostic variables based on simple clinical criteria, Cancer 39:303 (1977).

    Article  PubMed  CAS  Google Scholar 

  6. W.T. Chance, L. Cao, J.L. Nelson, T. Foley-Nelson, J.E. Fischer, Reversal of neurochemical aberrations after tumor resection in rats, Am J Surg 155:124 (1988).

    Article  PubMed  CAS  Google Scholar 

  7. J.A. Norton, J.F. Moley, M.V. Green, R.E. Carson, S.D. Morrison, Parabiotic transfer of cancer anorexia/cachexia in male rats, Cancer Res 45:5547 (1985).

    PubMed  CAS  Google Scholar 

  8. M.C. Stovroff, D.L. Fraker, J.A. Norton, Cachectin activity in the serum of cachectic, tumor-bearing rats, Arch Surg 124:94 (1989).

    Article  PubMed  CAS  Google Scholar 

  9. F.M. Van Lammeren, W.T. Chance, J.E. Fischer, Cholecystokinin-induced hypophagia is not potentiated by cancer anorexia, Peptides 5:97 (1984).

    Article  PubMed  Google Scholar 

  10. W.T. Chance, F.M. van Lammeren, M.H. Chen, W.J. Chen, R.F. Murphy, S.N. Joffe, J.E. Fischer, Plasma and brain cholecystokinin levels in cancer anorexia, J Surg Res 36:490 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. W.T. Chance, F.M. van Lammeren, J.E. Fischer, Feeding elicited by cholinergic and adrenergic hypothalamic stimulation of anorectic tumor-bearing rats, Pharmacol Biochem Behav 31:209 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. W.T. Chance, M. Muggia-Sullam, M.H. Chen, R.F. Murphy, J.E. Fischer, Reversal of tumor-induced biochemical abnormalities by insulin treatment in rats, J Natl Cancer Inst 77:497 (1986).

    PubMed  CAS  Google Scholar 

  13. W.T. Chance, L. Cao, T. Foley-Nelson, J.L. Nelson, J.E. Fischer, Possible role of ammonia in experimental cancer anorexia, Brain Res 486:316 (1989).

    Article  PubMed  CAS  Google Scholar 

  14. W.T. Chance, M. von Meyenfeldt, J.E. Fischer, Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia, Pharmacol Biochem Behav 18:115 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. T. Foley-Nelson, W.T. Chance, J.L. Nelson, L. Cao, J.E. Fischer, Delay of cancer anorexia following injection of 6-hydroxydopamine into the corpus striatum, Proc Soc Neurosci 12:1450 (1986).

    Google Scholar 

  16. K. Tatemoto, M. Carlquist, V. Mutt, Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide, Nature 296:659 (1982).

    Article  PubMed  CAS  Google Scholar 

  17. T. Hokfeldt, J.M. Lundberg, K. Tatemoto, et al., Neuropeptide Y (NPY)-and FMRF-amide neuropeptide-like immunoreactivities in catecholamine neurons of the medulla oblongata, Acta Physiol Scand 117:315 (1983).

    Article  Google Scholar 

  18. J.M. Lundberg, L. Terenius, T. Hokfeldt, et al., Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function, Acta Physiol Scand 116:393 (1982).

    Article  PubMed  CAS  Google Scholar 

  19. B.G. Stanley, S.F. Leibowitz, Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior, Proc Natl Acad Sci USA 82:3940 (1985).

    Article  PubMed  CAS  Google Scholar 

  20. S.P. Kalra, M.G. Dube, P.S. Kalra, Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokinin, Peptides 9:723 (1988).

    Article  PubMed  CAS  Google Scholar 

  21. W.T. Chance, L. Cao, J.L. Nelson, T. Foley-Nelson, J.E. Fischer, Hyperammonemia in anorectic tumor-bearing rats, Life Sci 43:67 (1988).

    Article  PubMed  CAS  Google Scholar 

  22. W.T. Chance, F.S. Zhang, T. Foley-Nelson, J.E. Fischer, Hyperammonemia and anorexia in Morris hepatoma-bearing rats, Physiol Behav 50:397 (1991).

    Article  PubMed  CAS  Google Scholar 

  23. W.T. Chance, M.F. von Meyenfeldt, J.E. Fischer, Changes in brain amines associated with cancer anorexia, Neurosci Biobehav Rev 50:397 (1991).

    CAS  Google Scholar 

  24. A. Balasubramaniam, D.W. McFadden, M. Rudnicki, et al., Radioimmunoassay to determine postprandial changes in plasma neuropeptide Y levels in awake dogs, Neuropeptides 14:209 (1989).

    Article  PubMed  CAS  Google Scholar 

  25. A. Unden, K. Tatemoto, V. Mutt, et al. Neuropeptide Y receptor in the rat brain, Eur J Biochem 145:526 (1984).

    Article  Google Scholar 

  26. G.L. Peterson, A simplification of the protein assay method of Lowry et al., which is generally more applicable, Anal Biochem 83:346 (1977).

    Article  PubMed  CAS  Google Scholar 

  27. A. Balasubramaniam, S. Sheriff, D.F. Rigel, et al., Characterization of neuropeptide Y binding sites in rat cardiac membranes, Peptides 11:545 (1990).

    Article  PubMed  CAS  Google Scholar 

  28. W.T. Chance, L. Cao, J.L. Nelson, T. Foley-Nelson, J.E. Fischer, Acivicin reduces tumor growth during total parenteral nutrition (TPN), Surgery 102:386 (1987).

    PubMed  CAS  Google Scholar 

  29. B.G. Stanley, S.E. Kyrkouli, S. Lampert, S.F. Leibowitz, Neuropeptide Y chronically injected in to the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity, Peptides 7:1189 (1986).

    Article  PubMed  CAS  Google Scholar 

  30. A. Sahu, P.S. Kalra, S.P. Kalra, Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus, Peptides 9:83 (1988).

    Article  PubMed  CAS  Google Scholar 

  31. S.P. Kalra, M.G. Dube, A. Sahu, C.P. Phelps, P.S. Kalra, Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food, Proc Natl Acad Sci USA 88:10931 (1991).

    Article  PubMed  CAS  Google Scholar 

  32. G. Williams, J.S. Gill, Y.C. Lee, H.M. Cardoso, B.E. Okpere, S.R. Bloom, Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats, Diabetes 38:321 (1989).

    Article  PubMed  CAS  Google Scholar 

  33. G. Truett, R.J. Martin, Neuropeptide Y in brain areas and tissues of Zucker rats, J Cell Biochem 13:243 (1989).

    Google Scholar 

  34. G. Sanacora, M. Kershaw, J.A. Finkelstein, J.D. White, Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation, Endocrinology 127:730 (1990).

    Article  PubMed  CAS  Google Scholar 

  35. W.T. Chance, L. Cao, J.E. Fischer, Tumor-induced alterations in brain neurotransmitter and plasma ammonia concentrations are normalized 24 hours after tumor resection, Life Sci 48:425 (1991).

    Article  PubMed  CAS  Google Scholar 

  36. W.T. Chance, L. Cao, J.L. Nelson, T. Foley-Nelson, J.E. Fischer, Hyperammonemia in anorectic tumor-bearing rats, Life Sci 43:67 (1988).

    Article  PubMed  CAS  Google Scholar 

  37. W.T. Chance, F.S. Zhang, J.E. Fischer, Methionine sulfoximine intensifies cancer anorexia, Pharmacol Biochem Behav 39:115 (1991).

    Article  PubMed  CAS  Google Scholar 

  38. J.M. Carrascosa, P. Martinez, I.N. de Castro, Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor cells, Cancer Res 44:3831 (1984).

    PubMed  CAS  Google Scholar 

  39. H. Matsuzaki, M. Uchiba, K. Yoshimura, M. Yoshida, Y. Akahoshi, K. Okazaki, K. Takatsuki, Hyperammonemia in multiple myeloma, Acta Haematol 84:130 (1990).

    Article  PubMed  CAS  Google Scholar 

  40. D.R. Liskowky, L.O.B. Norenberg, M.D. Norenberg, Effect of ammonia on cyclic AMP production in primary astrocyte cultures, Brain Res 386:386 (1986).

    Article  Google Scholar 

  41. A. Westlind-Danielsson, A. Unden, J. Abens, S. Andell, T. Bartfai, Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex, Neurosci Lett 74:237 (1987).

    Article  PubMed  CAS  Google Scholar 

  42. S. Kassis, O. Marjut, L. Terenius, P.H. Fishman, Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein, J Biol Chem 262:3429 (1987).

    PubMed  CAS  Google Scholar 

  43. W.T. Chance, S. Sheriff, T. Foley-Nelson, J.E. Fischer, A. Balasubramaniam, Pertussis toxin inhibits neuropeptide Y-induced feeding in rats, Peptides 10:1283 (1989).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, University of Cincinnati Medical Center, Veterans Affairs Medical Center, Cincinnati, OH, 45267, USA

    William T. Chance

  2. Department of Surgery, University of Cincinnati Medical Center, Cincinnati, OH, 45267, USA

    Ambikaipakan Balasubramaniam, Sulaiman Sheriff & Josef E. Fischer

Authors
  1. William T. Chance
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  2. Ambikaipakan Balasubramaniam
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  3. Sulaiman Sheriff
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  4. Josef E. Fischer
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Editor information

Editors and Affiliations

  1. American Institute for Cancer Research, Washington, D.C., USA

    Maryce M. Jacobs

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© 1994 Springer Science+Business Media New York

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Chance, W.T., Balasubramaniam, A., Sheriff, S., Fischer, J.E. (1994). Possible Role of Neuropeptide Y in Experimental Cancer Anorexia. In: Jacobs, M.M. (eds) Diet and Cancer. Advances in Experimental Medicine and Biology, vol 375. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0939-8_14

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  • DOI: https://doi.org/10.1007/978-1-4899-0939-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0941-1

  • Online ISBN: 978-1-4899-0939-8

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